ID A0A0L0FNG5_9EUKA Unreviewed; 461 AA.
AC A0A0L0FNG5;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial {ECO:0000313|EMBL:KNC78350.1};
GN ORFNames=SARC_09213 {ECO:0000313|EMBL:KNC78350.1};
OS Sphaeroforma arctica JP610.
OC Eukaryota; Ichthyosporea; Ichthyophonida; Sphaeroforma.
OX NCBI_TaxID=667725 {ECO:0000313|EMBL:KNC78350.1, ECO:0000313|Proteomes:UP000054560};
RN [1] {ECO:0000313|EMBL:KNC78350.1, ECO:0000313|Proteomes:UP000054560}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP610 {ECO:0000313|EMBL:KNC78350.1,
RC ECO:0000313|Proteomes:UP000054560};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Young S.K., Zeng Q., Gargeya S., Alvarado L., Berlin A.,
RA Chapman S.B., Chen Z., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E., Heiman D., Howarth C., Mehta T., Neiman D.,
RA Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., White J., Yandava C., Burger G., Gray M.W., Holland P.W.H.,
RA King N., Lang F.B.F., Roger A.J., Ruiz-Trillo I., Haas B., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Sphaeroforma arctica JP610.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the complex I 49 kDa subunit family.
CC {ECO:0000256|ARBA:ARBA00005769, ECO:0000256|RuleBase:RU003685}.
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DR EMBL; KQ242506; KNC78350.1; -; Genomic_DNA.
DR RefSeq; XP_014152252.1; XM_014296777.1.
DR AlphaFoldDB; A0A0L0FNG5; -.
DR STRING; 667725.A0A0L0FNG5; -.
DR EnsemblProtists; KNC78350; KNC78350; SARC_09213.
DR GeneID; 25909717; -.
DR eggNOG; KOG2870; Eukaryota.
DR OrthoDB; 191at2759; -.
DR Proteomes; UP000054560; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016651; F:oxidoreductase activity, acting on NAD(P)H; IEA:InterPro.
DR GO; GO:0048038; F:quinone binding; IEA:InterPro.
DR Gene3D; 1.10.645.10; Cytochrome-c3 Hydrogenase, chain B; 1.
DR HAMAP; MF_01358; NDH1_NuoD; 1.
DR InterPro; IPR001135; NADH_Q_OxRdtase_suD.
DR InterPro; IPR014029; NADH_UbQ_OxRdtase_49kDa_CS.
DR InterPro; IPR022885; NDH1_su_D/H.
DR InterPro; IPR029014; NiFe-Hase_large.
DR NCBIfam; TIGR01962; NuoD; 1.
DR PANTHER; PTHR11993:SF10; NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11993; NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT; 1.
DR Pfam; PF00346; Complex1_49kDa; 1.
DR SUPFAM; SSF56762; HydB/Nqo4-like; 1.
DR PROSITE; PS00535; COMPLEX1_49K; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027, ECO:0000256|RuleBase:RU003685};
KW Reference proteome {ECO:0000313|Proteomes:UP000054560};
KW Translocase {ECO:0000256|ARBA:ARBA00022967, ECO:0000256|RuleBase:RU003685};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003685};
KW Ubiquinone {ECO:0000313|EMBL:KNC78350.1}.
FT DOMAIN 191..461
FT /note="NADH-quinone oxidoreductase subunit D"
FT /evidence="ECO:0000259|Pfam:PF00346"
SQ SEQUENCE 461 AA; 52153 MW; FC7B169ED9A54DE6 CRC64;
MLLSFLRTAQ RSAVSKRSLP VLTTVASRSY VRLATSGRLP GDNLLKLPKA MMQETGHAIQ
DDGVEVEDYL DGFEVAQYTM NFGPQHPAAH GVLRLVLELE GEQVHRADPH VGLLHRGTEK
LIEYKTYTQA LPYFDRLDYV SMMCNEQAYS LATEKLLHLE VPIRAKYIRT LFGEFTRLLN
HIMSVTTHAL DVGALTPFLW LFEEREKMME FYERVSGARL HAAYVRPGGV AYDLPHGILE
DMHQFINNFS VRIDEVEDLL TGNRIWKQRL VDIAVVDSER ALNYGFSGPM LRGSGIAWDI
RKTQPYDAYD KVEFDIPVGV NGDCYDRYLC RVEEMRQSIR IIQQCINQMP EGEIKVDDAK
ICPPKRADMK QSMESLIHHF KLFTEGYSVP AGATYVGVEA PKGEFGTYLV SDGSSKPYRC
KIKAPGFVHL SSLDMMVADH MMADVVAVIG TQDVVFGEID R
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