ID A0A0L0FPR3_9EUKA Unreviewed; 630 AA.
AC A0A0L0FPR3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Polyadenylate-binding protein {ECO:0000256|RuleBase:RU362004};
DE Short=PABP {ECO:0000256|RuleBase:RU362004};
GN ORFNames=SARC_08782 {ECO:0000313|EMBL:KNC78792.1};
OS Sphaeroforma arctica JP610.
OC Eukaryota; Ichthyosporea; Ichthyophonida; Sphaeroforma.
OX NCBI_TaxID=667725 {ECO:0000313|EMBL:KNC78792.1, ECO:0000313|Proteomes:UP000054560};
RN [1] {ECO:0000313|EMBL:KNC78792.1, ECO:0000313|Proteomes:UP000054560}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP610 {ECO:0000313|EMBL:KNC78792.1,
RC ECO:0000313|Proteomes:UP000054560};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Young S.K., Zeng Q., Gargeya S., Alvarado L., Berlin A.,
RA Chapman S.B., Chen Z., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E., Heiman D., Howarth C., Mehta T., Neiman D.,
RA Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., White J., Yandava C., Burger G., Gray M.W., Holland P.W.H.,
RA King N., Lang F.B.F., Roger A.J., Ruiz-Trillo I., Haas B., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Sphaeroforma arctica JP610.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Binds the poly(A) tail of mRNA.
CC {ECO:0000256|RuleBase:RU362004}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU362004}.
CC -!- SIMILARITY: Belongs to the polyadenylate-binding protein type-1 family.
CC {ECO:0000256|ARBA:ARBA00008557, ECO:0000256|RuleBase:RU362004}.
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DR EMBL; KQ242423; KNC78792.1; -; Genomic_DNA.
DR RefSeq; XP_014152694.1; XM_014297219.1.
DR AlphaFoldDB; A0A0L0FPR3; -.
DR STRING; 667725.A0A0L0FPR3; -.
DR EnsemblProtists; KNC78792; KNC78792; SARC_08782.
DR GeneID; 25909286; -.
DR eggNOG; KOG0123; Eukaryota.
DR OrthoDB; 21912at2759; -.
DR Proteomes; UP000054560; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd12378; RRM1_I_PABPs; 1.
DR CDD; cd12379; RRM2_I_PABPs; 1.
DR CDD; cd12381; RRM4_I_PABPs; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR Gene3D; 1.10.1900.10; c-terminal domain of poly(a) binding protein; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR036053; PABP-dom.
DR InterPro; IPR006515; PABP_1234.
DR InterPro; IPR002004; PABP_HYD.
DR InterPro; IPR034364; PABP_RRM1.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR045305; RRM2_I_PABPs.
DR InterPro; IPR000504; RRM_dom.
DR NCBIfam; TIGR01628; PABP-1234; 1.
DR PANTHER; PTHR24012:SF491; POLYADENYLATE-BINDING PROTEIN; 1.
DR PANTHER; PTHR24012; RNA BINDING PROTEIN; 1.
DR Pfam; PF00658; PABP; 1.
DR Pfam; PF00076; RRM_1; 4.
DR SMART; SM00517; PolyA; 1.
DR SMART; SM00360; RRM; 4.
DR SUPFAM; SSF63570; PABC (PABP) domain; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS51309; PABC; 1.
DR PROSITE; PS50102; RRM; 4.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|RuleBase:RU362004};
KW Reference proteome {ECO:0000313|Proteomes:UP000054560};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176,
KW ECO:0000256|RuleBase:RU362004}.
FT DOMAIN 18..96
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 106..178
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 199..276
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 302..379
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 532..609
FT /note="PABC"
FT /evidence="ECO:0000259|PROSITE:PS51309"
FT REGION 449..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 609..630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 246..294
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 464..504
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 630 AA; 69336 MW; 815B238D330F05DA CRC64;
MSATPVAIVP KQGNVNSTSL YVGDLHPEVN EALLFEIFNA VGPVASIRVC RDNITRRSLG
YAYVNFHNFL DAERALDTMN YADIKEQPCR IMWSQRDPAQ RKSGLGNVFI KNLSKEIDNK
ALYDTFSAFG NILSCKIVEN EVCESLGYGF VHYESDESAE NAIEKVNGML LAGKKVFVGP
FIARKERQDG DEAPKIKFTN VFVKNFPTTW DSDKLREVFA DFGTVTSAVA NVNTDGTSAG
SGFVCFDNYE AAAKSVEAMN EKVIEEKALY CGRAQKKSER EAELRAKFDA LKLERAQKYH
GVNLYVKNLD DTLSEERVRT EFAPFGTITS LKIMHDDKGV SKGFGFVCFE TAEEATKAVT
EMNGRMLLSK PLYVALAQRK EDRKLQLQNQ YAVRANGMVR GPAGMQPQLY PAGGPMFYTG
PGVGVVPNGQ MVGGRRWTPP AGNVNVRGGY AQMPPPGYMG PGVNMQNVPQ QQQQRNGNNN
RNNNGRPQNG QQPRMPLQQN TRAGVNQYRQ SQGAIKQIVN PVPAVSPVFP GQEPLTASML
AEASAVQQKQ LLGERLYPLI AATHTELAGK ITGMLLEMDN SELLHLLETP DALSLKVKEA
VLVLETHQQQ LSDARTTDEN SHADVPTVAA
//
