ID A0A0L0FRU7_9EUKA Unreviewed; 670 AA.
AC A0A0L0FRU7;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=Ku domain-containing protein {ECO:0000259|SMART:SM00559};
GN ORFNames=SARC_08189 {ECO:0000313|EMBL:KNC79414.1};
OS Sphaeroforma arctica JP610.
OC Eukaryota; Ichthyosporea; Ichthyophonida; Sphaeroforma.
OX NCBI_TaxID=667725 {ECO:0000313|EMBL:KNC79414.1, ECO:0000313|Proteomes:UP000054560};
RN [1] {ECO:0000313|EMBL:KNC79414.1, ECO:0000313|Proteomes:UP000054560}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP610 {ECO:0000313|EMBL:KNC79414.1,
RC ECO:0000313|Proteomes:UP000054560};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Young S.K., Zeng Q., Gargeya S., Alvarado L., Berlin A.,
RA Chapman S.B., Chen Z., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E., Heiman D., Howarth C., Mehta T., Neiman D.,
RA Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., White J., Yandava C., Burger G., Gray M.W., Holland P.W.H.,
RA King N., Lang F.B.F., Roger A.J., Ruiz-Trillo I., Haas B., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Sphaeroforma arctica JP610.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ku80 family.
CC {ECO:0000256|ARBA:ARBA00007726}.
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DR EMBL; KQ242309; KNC79414.1; -; Genomic_DNA.
DR RefSeq; XP_014153316.1; XM_014297841.1.
DR AlphaFoldDB; A0A0L0FRU7; -.
DR STRING; 667725.A0A0L0FRU7; -.
DR EnsemblProtists; KNC79414; KNC79414; SARC_08189.
DR GeneID; 25908693; -.
DR eggNOG; KOG2326; Eukaryota.
DR OrthoDB; 5884at2759; -.
DR Proteomes; UP000054560; Unassembled WGS sequence.
DR GO; GO:0043564; C:Ku70:Ku80 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0042162; F:telomeric DNA binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0000723; P:telomere maintenance; IEA:InterPro.
DR CDD; cd00873; KU80; 1.
DR Gene3D; 1.10.1600.10; -; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 1.25.40.240; Ku, C-terminal domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR024193; Ku80.
DR InterPro; IPR036494; Ku_C_sf.
DR InterPro; IPR005161; Ku_N.
DR InterPro; IPR014893; Ku_PK_bind.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR12604; KU AUTOANTIGEN DNA HELICASE; 1.
DR PANTHER; PTHR12604:SF4; X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 5; 1.
DR Pfam; PF02735; Ku; 1.
DR Pfam; PF03731; Ku_N; 1.
DR Pfam; PF08785; Ku_PK_bind; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF101420; C-terminal domain of Ku80; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054560}.
FT DOMAIN 232..369
FT /note="Ku"
FT /evidence="ECO:0000259|SMART:SM00559"
SQ SEQUENCE 670 AA; 75786 MW; 7A5F8859BC709E3F CRC64;
MNICMQRELM KPDFKLVQML KEDIEMGCEY SADWFDGLIV SIKHLDVVIA KKKFNKVIWV
LTNDVNTPNG IEDDELESVM NKIKDADMRV NFVGLKVDED DNGDYVPIEG DGETEDELRA
MEQVCRIANA SHGVIMEFPW AFDKLREEGY KRTKSNPIFK GKLDIGNDFA LPVQMLSRVK
ETLKPSYKQS SVYKPEPTSN GTLKLELDSG DMPMASSLNE VKRTTEYTDV DGKKIDKTRL
QTSYRYGAET VHVPDYSDPL IQYKTEQSMK LICFTPKNNI PPSLLMGDTY ELQPPQGDVD
AYRALTAMIR GTEQAGKVGI VRTVMKDNKD VALGVLRPHV RETYATFLYN RLPFADDMRQ
FNLPSLQNTK TPPTRDQAET IDNLIDSMDL MEADRDLDGD PREAYQSKNT LNPALQYYHS
VVFETKADNL ARMAPLESFL EPVSRKIDDR SADERVGRLI ADNFELKAAE KSKSRVRSSF
NAFKKTPIDA AEEDALENGP DIPMGADTES SILRIAGDRV TQVGTISPVS DFKMMMTQTE
DLKLRDAALV QIKEVIQDLV ARSMGEEHLV VPLDCVRTLR ETCVKNVDAA SFNDWIKEYK
DEIDDPQSHG YSFWHLLVEN RLSLITQDET NNTADPSAIE ADKFLGAKTV KEVAPAEQDS
DLDDMMDDFE
//
