ID A0A0L0G2C2_9EUKA Unreviewed; 624 AA.
AC A0A0L0G2C2;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Inward rectifier potassium channel C-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=SARC_04519 {ECO:0000313|EMBL:KNC83220.1};
OS Sphaeroforma arctica JP610.
OC Eukaryota; Ichthyosporea; Ichthyophonida; Sphaeroforma.
OX NCBI_TaxID=667725 {ECO:0000313|EMBL:KNC83220.1, ECO:0000313|Proteomes:UP000054560};
RN [1] {ECO:0000313|EMBL:KNC83220.1, ECO:0000313|Proteomes:UP000054560}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP610 {ECO:0000313|EMBL:KNC83220.1,
RC ECO:0000313|Proteomes:UP000054560};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Young S.K., Zeng Q., Gargeya S., Alvarado L., Berlin A.,
RA Chapman S.B., Chen Z., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E., Heiman D., Howarth C., Mehta T., Neiman D.,
RA Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., White J., Yandava C., Burger G., Gray M.W., Holland P.W.H.,
RA King N., Lang F.B.F., Roger A.J., Ruiz-Trillo I., Haas B., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Sphaeroforma arctica JP610.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU003822}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU003822}.
CC -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel (TC
CC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822}.
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DR EMBL; KQ241853; KNC83219.1; -; Genomic_DNA.
DR EMBL; KQ241853; KNC83220.1; -; Genomic_DNA.
DR RefSeq; XP_014157121.1; XM_014301646.1.
DR RefSeq; XP_014157122.1; XM_014301647.1.
DR AlphaFoldDB; A0A0L0G2C2; -.
DR STRING; 667725.A0A0L0G2C2; -.
DR EnsemblProtists; KNC83219; KNC83219; SARC_04519.
DR EnsemblProtists; KNC83220; KNC83220; SARC_04519.
DR GeneID; 25905023; -.
DR eggNOG; KOG3827; Eukaryota.
DR OrthoDB; 4126787at2759; -.
DR Proteomes; UP000054560; Unassembled WGS sequence.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.40.1400; G protein-activated inward rectifier potassium channel 1; 1.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR041647; IRK_C.
DR InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR InterPro; IPR040445; Kir_TM.
DR PANTHER; PTHR11767; INWARD RECTIFIER POTASSIUM CHANNEL; 1.
DR PANTHER; PTHR11767:SF102; INWARDLY RECTIFYING POTASSIUM CHANNEL 1, ISOFORM F; 1.
DR Pfam; PF01007; IRK; 1.
DR Pfam; PF17655; IRK_C; 1.
DR PRINTS; PR01320; KIRCHANNEL.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU003822};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU003822};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958, ECO:0000256|RuleBase:RU003822};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538,
KW ECO:0000256|RuleBase:RU003822};
KW Reference proteome {ECO:0000313|Proteomes:UP000054560};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003822};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU003822};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU003822}.
FT TRANSMEM 53..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 22..151
FT /note="Potassium channel inwardly rectifying transmembrane"
FT /evidence="ECO:0000259|Pfam:PF01007"
FT DOMAIN 193..331
FT /note="Inward rectifier potassium channel C-terminal"
FT /evidence="ECO:0000259|Pfam:PF17655"
FT REGION 345..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 491..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..371
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..473
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 491..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 624 AA; 68492 MW; E3FF213F513BDF9A CRC64;
MDYIYRRRAA QKPKIAQYCR LVKKDGTLNV QYIGCPVKYN VSNMYHDIVD KNWPFLIVLI
TVMYTSCALF FATLYWIDGG VLKSYTSPSD QELTFPEAYY FSVQTQDTIG YGALYPGDQV
TTNLISALQS WLSMLVYATI TGIVFTKLSR PSKIKNNIMF SSNAVINNTS SLTFVPNARG
GDETEGEYRS GEEPCLVFRI ANVRKAQLCA ASFTLLCVSY KPNEHGEQYT TQELNFEINQ
QVGRVRGMNF SVPQLNLPWN VVHPIDRSSP LYGLTAKEVI RNRIEIIAVL DAIDEACADN
FQARSSYTAN DIHWQAEFAD MVACVSKNKV SEHIKAVRQQ SLLRRRSETS VEKARRTSKG
SSPTCAPPNG SIGGESSLGL RKLINDNTVI SKAQPVSPMI KQNRRYSGGG IHVMPRLGVM
PGNGTTSKVH LGVISKVLNT GVGVADTANE PAHKLQTQTG TKQTDSVGNR PQNLSPDAAY
KLAVNIVDET SPYSQRTTSR DTTAGIPDGE TLPLIAATSI EVLSRDNASD VSSAGSSSAT
HGMIVGLQRR GLVEPKLRHV SSLTSVNEDA IVDMFDHTDT GHRERSPEDV VDEAMFVAFD
GILVANFSLF DTVLPLPSSE DVDS
//
