ID A0A0L0G7Q9_9EUKA Unreviewed; 592 AA.
AC A0A0L0G7Q9;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Prolyl 4-hydroxylase alpha subunit domain-containing protein {ECO:0000259|SMART:SM00702};
GN ORFNames=SARC_02850 {ECO:0000313|EMBL:KNC84959.1};
OS Sphaeroforma arctica JP610.
OC Eukaryota; Ichthyosporea; Ichthyophonida; Sphaeroforma.
OX NCBI_TaxID=667725 {ECO:0000313|EMBL:KNC84959.1, ECO:0000313|Proteomes:UP000054560};
RN [1] {ECO:0000313|EMBL:KNC84959.1, ECO:0000313|Proteomes:UP000054560}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JP610 {ECO:0000313|EMBL:KNC84959.1,
RC ECO:0000313|Proteomes:UP000054560};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Young S.K., Zeng Q., Gargeya S., Alvarado L., Berlin A.,
RA Chapman S.B., Chen Z., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA Gujja S., Heilman E., Heiman D., Howarth C., Mehta T., Neiman D.,
RA Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., White J., Yandava C., Burger G., Gray M.W., Holland P.W.H.,
RA King N., Lang F.B.F., Roger A.J., Ruiz-Trillo I., Haas B., Nusbaum C.,
RA Birren B.;
RT "The Genome Sequence of Sphaeroforma arctica JP610.";
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC Evidence={ECO:0000256|ARBA:ARBA00001961};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KQ241729; KNC84959.1; -; Genomic_DNA.
DR RefSeq; XP_014158861.1; XM_014303386.1.
DR AlphaFoldDB; A0A0L0G7Q9; -.
DR STRING; 667725.A0A0L0G7Q9; -.
DR EnsemblProtists; KNC84959; KNC84959; SARC_02850.
DR GeneID; 25903354; -.
DR eggNOG; ENOG502S6K3; Eukaryota.
DR OrthoDB; 5490703at2759; -.
DR Proteomes; UP000054560; Unassembled WGS sequence.
DR GO; GO:0051213; F:dioxygenase activity; IEA:UniProtKB-KW.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0031418; F:L-ascorbic acid binding; IEA:UniProtKB-KW.
DR GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 1.
DR InterPro; IPR006620; Pro_4_hyd_alph.
DR InterPro; IPR044862; Pro_4_hyd_alph_FE2OG_OXY.
DR PANTHER; PTHR12117; HISTONE ACETYLTRANSFERASE COMPLEX; 1.
DR PANTHER; PTHR12117:SF0; PROLYL 3-HYDROXYLASE OGFOD1; 1.
DR Pfam; PF13640; 2OG-FeII_Oxy_3; 1.
DR SMART; SM00702; P4Hc; 1.
DR SUPFAM; SSF51197; Clavaminate synthase-like; 2.
PE 4: Predicted;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000054560};
KW Vitamin C {ECO:0000256|ARBA:ARBA00022896}.
FT DOMAIN 382..551
FT /note="Prolyl 4-hydroxylase alpha subunit"
FT /evidence="ECO:0000259|SMART:SM00702"
SQ SEQUENCE 592 AA; 65695 MW; BD32256392AA7C1A CRC64;
MKGGKHNKGH KGLPHGKRRA ALATSLFPNV NNGAAFLSAW EARQPCYMES CALAVSLKDI
TADNIITSTC GAAKECAYGR DVVHTQSQSL AMSKRIYEWH GDLHGSVSDI RLQELISPTK
GAGNSVRFLR QEMRAPLIAL AKAVDTFWKG EGGVSVCVDV VTHDALFAPP SLYSTDTLLI
QTEGSLHVQL IDVADEWLAI GQHCAYKSHR PCSQFPTLFT TEGTILVDAE EPKIVQDLIL
NPGDVLYVPQ HLIVFADTQH EECDIKEGVS TTASVALPSQ PVWSDVVDAS VMGALEVLGH
DPDSRLFPRR KVTDVGLTLT QSMGEEGTVA NSIVKEVLQT ALELANTTLK HMESRCAYTH
TDFDNSDRFK KMDIHALLEE NDGIVKIPNV LPKEMADKVL HTLQNISEAE WHLAENGSAD
KNYATEVSHA FMSARSFPNS DFVLDMFHDL LPLSPALFSA GKYTKGHFIE AHDDRAYKEI
GGETYSRDIA CIYYLTKDWS EKDGGALLDM ESKIAHIPEF NSMIIFQVPR WHEVQPMVSD
RERFSIFGWF LNPGKQYPLT DDVELEEQLD GVPLRATKRS RRSGWSVETL KT
//
