ID   A0A0L0GBX5_9EUKA        Unreviewed;       739 AA.
AC   A0A0L0GBX5;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 27.
DE   RecName: Full=Choline/carnitine acyltransferase domain-containing protein {ECO:0000259|Pfam:PF00755};
GN   ORFNames=SARC_01459 {ECO:0000313|EMBL:KNC86409.1};
OS   Sphaeroforma arctica JP610.
OC   Eukaryota; Ichthyosporea; Ichthyophonida; Sphaeroforma.
OX   NCBI_TaxID=667725 {ECO:0000313|EMBL:KNC86409.1, ECO:0000313|Proteomes:UP000054560};
RN   [1] {ECO:0000313|EMBL:KNC86409.1, ECO:0000313|Proteomes:UP000054560}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JP610 {ECO:0000313|EMBL:KNC86409.1,
RC   ECO:0000313|Proteomes:UP000054560};
RG   The Broad Institute Genome Sequencing Platform;
RA   Russ C., Cuomo C., Young S.K., Zeng Q., Gargeya S., Alvarado L., Berlin A.,
RA   Chapman S.B., Chen Z., Freedman E., Gellesch M., Goldberg J., Griggs A.,
RA   Gujja S., Heilman E., Heiman D., Howarth C., Mehta T., Neiman D.,
RA   Pearson M., Roberts A., Saif S., Shea T., Shenoy N., Sisk P., Stolte C.,
RA   Sykes S., White J., Yandava C., Burger G., Gray M.W., Holland P.W.H.,
RA   King N., Lang F.B.F., Roger A.J., Ruiz-Trillo I., Haas B., Nusbaum C.,
RA   Birren B.;
RT   "The Genome Sequence of Sphaeroforma arctica JP610.";
RL   Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KQ241653; KNC86409.1; -; Genomic_DNA.
DR   RefSeq; XP_014160311.1; XM_014304836.1.
DR   AlphaFoldDB; A0A0L0GBX5; -.
DR   STRING; 667725.A0A0L0GBX5; -.
DR   EnsemblProtists; KNC86409; KNC86409; SARC_01459.
DR   GeneID; 25901963; -.
DR   eggNOG; KOG3716; Eukaryota.
DR   OrthoDB; 1429709at2759; -.
DR   Proteomes; UP000054560; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR   InterPro; IPR000542; Carn_acyl_trans.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR039551; Cho/carn_acyl_trans.
DR   InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR   PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR   Pfam; PF00755; Carn_acyltransf; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|RuleBase:RU003801}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054560};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        40..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        73..91
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          101..707
FT                   /note="Choline/carnitine acyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00755"
FT   ACT_SITE        409
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ   SEQUENCE   739 AA;  83809 MW;  47F46206AA3119A6 CRC64;
     MTSTSNFATY ATHAINAAKD LTIGSGSLRM TYVNFVTGPW TLLLFPFHVL RVALLRTLLT
     YNGWTTRPHA TSTMVYFLVL KLLVMFPVPT FQSLQKSMPC LPVPSLKESC DQFITSVEPL
     LTPEQLQKTK DDLQRFQTNG TGQQLQSTLQ YLYWSKDNWL SDIWLRAAYL MTREFLPCAA
     SWYSSDLMPY LREQHTKNQA ERSATLIYAT LNIRDHVLNK RDFEGLYTAV AMPLCMNGYQ
     DTFGTTRVPK KGEDFLEHHP QSSYITVLCQ NFAFKVEVVH KDGSRASVKQ LQHQFEYVMA
     TAKAMKEDGV EPNDVCVLTS QNRDVWADER EALIQSSAEN AQKLHTIESS AIVLSLDHES
     PVPRGDKKNL NLDEYATAMQ HNHGQNRWFD KSMNIITFPD GYAAVQFEHS FADGSVNGHL
     WEAILLLEAR MYKHVYSRVQ RISAEKKKKC PVPIHDKIAK ENARQTNNRL DLPTAIQFDL
     TPRSQKACQV AQETIKRELK DVSQGCLIKT GLGKSHFKKL KMSPDAFLQM ALQLAHRRVM
     GYYTLTYEPV SMRAWRLGRT ETNRVLSNES KKFCDAMIAR ETNSADAPTS AETISLLKAA
     EKKHVNRIRS AMFGKGVDRH IMSMKIVAMS QGLDIKDMLD GPAFTLPWGL VTTTTPLLFG
     PKYKQLYSSL EESVVTVGGG FTSYQPDSLG MAYFFYDDGM SFHTTVRVGD KIKDAEATRL
     QFQDAVVQAM DEIYALHKE
//