ID A0A0L0H805_SPIPD Unreviewed; 2024 AA.
AC A0A0L0H805;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Actin cytoskeleton-regulatory complex protein pan1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=SPPG_07456 {ECO:0000313|EMBL:KNC97059.1};
OS Spizellomyces punctatus (strain DAOM BR117).
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Chytridiomycetes; Spizellomycetales;
OC Spizellomycetaceae; Spizellomyces.
OX NCBI_TaxID=645134 {ECO:0000313|EMBL:KNC97059.1, ECO:0000313|Proteomes:UP000053201};
RN [1] {ECO:0000313|EMBL:KNC97059.1, ECO:0000313|Proteomes:UP000053201}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DAOM BR117 {ECO:0000313|EMBL:KNC97059.1,
RC ECO:0000313|Proteomes:UP000053201};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shenoy N., Sisk P., Stolte C., Sykes S., Thomson T., Walk T.,
RA White J., Yandava C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Spizellomyces punctatus strain DAOM BR117.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; KQ257465; KNC97059.1; -; Genomic_DNA.
DR RefSeq; XP_016605099.1; XM_016755621.1.
DR STRING; 645134.A0A0L0H805; -.
DR GeneID; 27690670; -.
DR VEuPathDB; FungiDB:SPPG_07456; -.
DR eggNOG; KOG1029; Eukaryota.
DR eggNOG; KOG4226; Eukaryota.
DR eggNOG; KOG4305; Eukaryota.
DR InParanoid; A0A0L0H805; -.
DR OMA; DATVYKY; -.
DR OrthoDB; 2734911at2759; -.
DR Proteomes; UP000053201; Unassembled WGS sequence.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00030; C2; 1.
DR CDD; cd00052; EH; 2.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00174; SH3; 2.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 1.10.238.10; EF-hand; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR000261; EH_dom.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR46006:SF5; DH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46006; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR AT 64C, ISOFORM A; 1.
DR Pfam; PF00168; C2; 1.
DR Pfam; PF12763; EF-hand_4; 2.
DR Pfam; PF16652; PH_13; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00239; C2; 1.
DR SMART; SM00027; EH; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 2.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF47473; EF-hand; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 2.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50031; EH; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 2.
PE 4: Predicted;
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Reference proteome {ECO:0000313|Proteomes:UP000053201};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 71..164
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 273..362
FT /note="EH"
FT /evidence="ECO:0000259|PROSITE:PS50031"
FT DOMAIN 306..341
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 1262..1319
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1337..1397
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 1549..1732
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1772..1879
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1882..2003
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 408..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 540..571
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..809
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 827..1110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1161..1183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1400..1422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1481..1505
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 542..571
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 592..613
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..713
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..738
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..775
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 779..809
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..885
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 889..903
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 927..946
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 953..983
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1010
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1021..1045
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1066..1085
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1407..1421
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2024 AA; 217146 MW; 17D102A09B16389C CRC64;
MSFQGYGQGS QGFPSQPGGG WGQPSQQGLG AGMFPGQPMG YQAPNFQAAA GSGIGTELAA
QVSLPFIEHS DLANYENLFK QANPSSTGHI AAPAARNILV QSGLPNEILA RIWSLSAVST
STSLNFAEFC LAMHLAKLGR NGTMPPPQLP DTVRQQLMAS TANLTRAAQG AASGGGGLSA
PLGSYTGSAG VTTNLTGGHG STGYLTPTST GNASFSGVPR NSTTGMSRSS SFQGVPSGVT
VMDGFAGPLV AQAPIQSQSS QGQRQKWAVD PAEKAQYDAI FKVWDPQNSG FISGDRARNI
FTQSGLPDGV LAHIWTLADI QKNGKLNADE FAVAMHLVYQ KLNGRDLPAT LPPELIPPST
RDLDSLTNLA KTQIMSDIVN KKTNPLQRSP FGSSSNLFGI ADPLGSFGST SPNLSDRRKL
QEQRDQEEAK RKTIVEKLET KKRELAELRQ KTADTNKSAT QIQLDIDRLH RDAREGHSDV
KYTTTTKESL LEQLQSRSGS GSRGGAETID QAMNMEKEIR NLLDDCRAFH NKYADQKIQK
LRGASGAQSG SGTSVPGGIS TLLPNTGSSD PVQSKAAALL AARMAALGVS GPSPSPLSSS
PSEKSSSNSG AVQAEIAKVE EERRRRLKEL DDASDRVRSI MEQVRSSAPS NASSLNIPRI
WNPPVEEKLK FEQGVGLKSK TVRKVIEDLD RQGGYATSTS SWASSNTQPL SAPRDSDAPA
RKPSLSSSAI STSFPSVPSV PRAGVPDRKT DSTPTSALKS PDPWTPAPPV PAREPPALSF
LSNLSSSSAP LNGGNHSPVA GPSLPSPTSA AVNDVVAQAE AAIRAAKERQ AKRLAGAGTP
TTPGTPTGAG SGNPFGASST SAGTIPATTT GSESTAFNAF SNTSFGAPKP AEEDDEVSKA
MQRLREQEQQ LLGENFRLGA GNVGASVPAP TVNNRSQENH PSTVTQGVLA AMEKIRQREK
EVLAEQQRIM QEDRERKEKL PAPRKSISGT SAQMPDRSVS SGSGSSFPRS PLGISKDAFQ
SAPSKKEQGI TPPSNAGNDQ SEPRTLSPPL APAISVQEPP EQDGSLPKVG GPPPPPPPPP
PGEVKPVKKY VRGTASPTSS GESTPKRKPT LADVGARVPA LFAAGAAPVQ SIGKVSDRIK
NLQGGMAHIF GAPVAIGQQE DTLEHSSHLS PTQAEGTSSG LESDWEVVSK EDTKNHEQLS
KDPTLNVGFT TKGGFLDIGA SGALGRAVSI GDVFSDKFAS SPLHPDPVVI SPITITPADA
GSILYKARAA YAYEGGADDL RLDVGDVVQV EQEQGEWLYG RVDGRAGWFP KTYVDVIAED
SVVDTARAPT PALLSSRFIS RGTALWDYTA LQSDEVDLVA GETVGILEKP EQEWWKVENS
RGEAGLVPSN YLQEAPDEDG IQLDDTSTAP AGASGGTARS SATELFGKPI ESRASSVNSS
FYESASDAGA GHATPPLPPK NKVHVMPRSS SLNIHSLAAY GEDEGSEGRP SIGLSSRESN
FEDEGDRHVL RSGIPKSTSF AVQPSQASTA WATKVDPYRL QTIAPDERKR QEAIYELIAT
EQTYVRDLEL IYQTFYGPMS QILPHGDLEA VFSNIEDIKM VNAVILSDLE AVQQEHDFVI
EAIGDVFCKH ADSLSVYQTY CGNFGNALKV LQKQRSENPR VAEYLKRQQT SNPLCRSLDL
SSFLLQPMQR ITRYSLLLKQ ILHHTSKTHP DHESVVRALA MSEKAAEMVN TAARERESRE
KLEEVMKILD LTCDEEHRLD LSAPTRVLGP RIFVHEGPLM KSKSGRKLHA YLFNDVLLLA
QPKGKQDRNA RGYQFALYRK PMPLNEIAVR DLPKLAGRDH GAVDETCFQV IHGQDAVTVR
APSVAAKRKW VNTLEEQSRH YYMAEKQQAE GSWKGGRFTY GTPIGTLQVM VAEAKNLVRV
DRGHKLDLFC RVQLNRQQVK TRTVHSVAPR WNQALVFSVL SLDETLKISV YNYDRYSQDD
YLGQAELALD FLEYYGEKET EPITLGLRDV ASGSVVIRLM YRKT
//
