ID A0A0L0H8G3_SPIPD Unreviewed; 934 AA.
AC A0A0L0H8G3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=SPPG_09468 {ECO:0000313|EMBL:KNC97502.1};
OS Spizellomyces punctatus (strain DAOM BR117).
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Chytridiomycetes; Spizellomycetales;
OC Spizellomycetaceae; Spizellomyces.
OX NCBI_TaxID=645134 {ECO:0000313|EMBL:KNC97502.1, ECO:0000313|Proteomes:UP000053201};
RN [1] {ECO:0000313|EMBL:KNC97502.1, ECO:0000313|Proteomes:UP000053201}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DAOM BR117 {ECO:0000313|EMBL:KNC97502.1,
RC ECO:0000313|Proteomes:UP000053201};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shenoy N., Sisk P., Stolte C., Sykes S., Thomson T., Walk T.,
RA White J., Yandava C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Spizellomyces punctatus strain DAOM BR117.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; KQ257464; KNC97502.1; -; Genomic_DNA.
DR RefSeq; XP_016605542.1; XM_016757635.1.
DR AlphaFoldDB; A0A0L0H8G3; -.
DR STRING; 645134.A0A0L0H8G3; -.
DR GeneID; 27692593; -.
DR VEuPathDB; FungiDB:SPPG_09468; -.
DR eggNOG; KOG1123; Eukaryota.
DR InParanoid; A0A0L0H8G3; -.
DR OMA; GKQKDPI; -.
DR OrthoDB; 1360679at2759; -.
DR Proteomes; UP000053201; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd18029; DEXHc_XPB; 1.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001161; XPB/Ssl2.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR NCBIfam; TIGR00603; rad25; 1.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:KNC97502.1};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:KNC97502.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022806,
KW ECO:0000313|EMBL:KNC97502.1}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053201}.
FT DOMAIN 469..631
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 685..842
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 36..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 934 AA; 104939 MW; 082B562C1874DCBE CRC64;
MERSSSIGRR TSMRHAAVKA RARLTAVRLD VDGIIEQGSA SQPQPELLSE CGDGGSDFES
GSNVRSQAKA IAQGLYTSHE EALHSRNYDN EDVTGPCTTE SDAPSRRGIK RQVDMQTTRL
PKRRRREVKD TQSPAPAFLP ERVYSPDDEA PEEDDALYSA TIDLGQFEEA ISDLFESEDL
SFAPLKADHE SRPLWVCQDG RIILEAFSPI AEQAQDFLVA ISEPVTRPSH VHEYRLSEYS
LYAAVSVGLD TDGIIQVLDR LSKTQLPPTV EKFIRENTQS YGKVKLVLKQ NRYWIESADE
MILQTLLKDE KIRECRLALQ GADSGIFGFL TEQAPDSKGF TIAGSKGNEQ VKPNRDDARQ
SSRTSDPALS TGQGFFIHEK PLSPKSTVEI SHVVDEVLEG IDLFELFSCD PDDDLNPDEM
TKYIAKPNGD DATGQSSNGS KDIVNPNLDV DLKATTKLRP YQERSLSKMF GNGRAKSGII
VLPCGAGKTL VGVTAACTIK KSCLVLCTSS VSVEQWAKEF RSWSTVREGQ IAKFTSQEKE
KFVGDAGILI STYTMVTYSG KRAYDAQQMM DFIRSREWGF LLLDEVHVVP ADMFRKVLTI
VAAHAKLGLT ATLVREDDKI GNLNYLIGPK LYEANWLDLS RKGHIANVQC AEVWCNMTPE
FYREYLREKS RRRQLLYAMN PRKLQACQYL IDFHESRGDK IIVFSDNVFA LKHYATKLNK
PYIYGGTSPA ERMRVLHQFQ HNPAINTIFL SKVGDTSIDL PEATCLIQVS SHYGSRRQEA
QRLGRILRAK QRTDDGINAY FYSLVSRDTE EVYYSAKRQR FLIDQGYQFK VINKLEGLEN
ISDLVYATRA EQLELLNTVL VSTEVDEDDS DILPPDDIRS LRARLEPVVV RRSGTLQSLS
GGDSMAYIEY SKTSTSGITK EKRSLFYKNW KSSR
//
