ID A0A0L0HDG0_SPIPD Unreviewed; 1184 AA.
AC A0A0L0HDG0;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0000259|PROSITE:PS50009};
GN ORFNames=SPPG_04906 {ECO:0000313|EMBL:KNC99515.1};
OS Spizellomyces punctatus (strain DAOM BR117).
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Chytridiomycetes; Spizellomycetales;
OC Spizellomycetaceae; Spizellomyces.
OX NCBI_TaxID=645134 {ECO:0000313|EMBL:KNC99515.1, ECO:0000313|Proteomes:UP000053201};
RN [1] {ECO:0000313|EMBL:KNC99515.1, ECO:0000313|Proteomes:UP000053201}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DAOM BR117 {ECO:0000313|EMBL:KNC99515.1,
RC ECO:0000313|Proteomes:UP000053201};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shenoy N., Sisk P., Stolte C., Sykes S., Thomson T., Walk T.,
RA White J., Yandava C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Spizellomyces punctatus strain DAOM BR117.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KQ257457; KNC99515.1; -; Genomic_DNA.
DR RefSeq; XP_016607555.1; XM_016753145.1.
DR AlphaFoldDB; A0A0L0HDG0; -.
DR STRING; 645134.A0A0L0HDG0; -.
DR GeneID; 27688331; -.
DR VEuPathDB; FungiDB:SPPG_04906; -.
DR eggNOG; KOG3417; Eukaryota.
DR InParanoid; A0A0L0HDG0; -.
DR OMA; DHANGMP; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000053201; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF99; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 1; 1.
DR Pfam; PF00617; RasGEF; 1.
DR SMART; SM00147; RasGEF; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000053201}.
FT DOMAIN 271..494
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 72..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 128..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 203..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..675
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 689..730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 742..776
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 805..1184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 128..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 689..713
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 714..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 834..869
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 870..886
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 943..967
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 977..1007
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1023..1037
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1054..1072
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1083..1102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1112..1126
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1127..1143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1144..1159
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1184 AA; 128938 MW; 1687EF59636C6253 CRC64;
MHAIRSAAAD AASKTVPKDS YFAQLKVLNG ILLQLKSAEF TSDGRPERQD DRIELLGMCR
QCIDTMEGVL RQADGRSQTK QPKAGPSLPP KPKLTIQPIT DRDSIASNPF MDASEHTPVN
DKQLTSVAAQ NSGTGPPPQI SLSSRESDDL FSPYSPRPSG SNGSTLENPK PKHVRPWASP
DIPPSPLLVQ YRELNSQLYE AMGRPGLEKG PSSASLYHDG EEHPTTPQRL ESAPTHRRSL
SDGATTVRSK LARVIYQILL AASAANVTTF RPVVVAFELC LIDQKIFDKL RPADMINHRP
PNNPSPSVHA STEFFNYLTR MIEFSILEPV EAGDRAVVIH SWTKVAWNLY QLRNLQSLKA
IVSALGTPPI ARLKRTWGLV PKKSMTTLEQ LRELLSEQNN YTAYREWLAR SVTRPMVPFL
GVYMHDITYL LALAKKDGTS PASDKRLKEI FDQMEFYQAG QKYAYEQLTA LLRLEKKSGA
LGFKKQQKSG ISSRAPPELL PLREADDETV GQFVGHWILS RKWYTEKEMD ALSLAREPRH
ITESTTPNSS NSTPLSQIVI EDVMSEPIPD FGGSGYDYLA ANNIAVPPEF FGGVNAASIL
SELKQNRKRM SAGAMLMEAL KGSALSFGSK KQASIPRRRS MGAVNGIAEN VATASGKSDV
SGADDDGRSS VTSSSSEWSL SSLKSLVFEG EEGGDKGRDG LDGEERYTDH GDGRSSDSQS
ITKQGKPSLG WLSTELKSRI EQMSTTPPGS TSNGTTSGSV QSPASEASPR TNKRQQNRIS
AIFTGFVGGG ASSNNSALPE KLANHAETHA ESDAFPSNHR NVSGKRGFGY VPGSPSSHIS
SLAPSSSRSH RRTQSTPHAR FTDASSDAQA HTQPKRDLHK NHLAGEADAH GPPPRPIPPN
RRGESFNGDP FKDGPENHVP RIAPKSSLSK AEVLHEDGRT RSQSHPPPPP IHQPPPRPPP
PKRDAPTPHP ASHASISHAP ASHSPASHSL SSSHSGVSHS VASSHSHPIP SHAEHDESGW
RKQSSTGRWT LHQTGSDKGY QGDAEFRQGH EPKDGGNISS STPTTAPTQR HHRTPTPFKH
PPLIPQQSTH QQSISHHPPT HQPASYHPSP QRLLRPEDDH IKRQPHRYTW TPTTAAPTIP
RSSERPTPSA PPAVPPKPPG MREAGREAVG REPPVVPPKP GRRT
//
