ID A0A0L0HNC3_SPIPD Unreviewed; 637 AA.
AC A0A0L0HNC3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=phosphoserine phosphatase {ECO:0000256|ARBA:ARBA00012640};
DE EC=3.1.3.3 {ECO:0000256|ARBA:ARBA00012640};
DE AltName: Full=O-phosphoserine phosphohydrolase {ECO:0000256|ARBA:ARBA00031693};
GN ORFNames=SPPG_03024 {ECO:0000313|EMBL:KND02567.1};
OS Spizellomyces punctatus (strain DAOM BR117).
OC Eukaryota; Fungi; Fungi incertae sedis; Chytridiomycota;
OC Chytridiomycota incertae sedis; Chytridiomycetes; Spizellomycetales;
OC Spizellomycetaceae; Spizellomyces.
OX NCBI_TaxID=645134 {ECO:0000313|EMBL:KND02567.1, ECO:0000313|Proteomes:UP000053201};
RN [1] {ECO:0000313|EMBL:KND02567.1, ECO:0000313|Proteomes:UP000053201}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DAOM BR117 {ECO:0000313|EMBL:KND02567.1,
RC ECO:0000313|Proteomes:UP000053201};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Bochicchio J.,
RA Borenstein D., Chapman S., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shenoy N., Sisk P., Stolte C., Sykes S., Thomson T., Walk T.,
RA White J., Yandava C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Lander E., Nusbaum C.;
RT "The Genome Sequence of Spizellomyces punctatus strain DAOM BR117.";
RL Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Amino-acid biosynthesis; L-serine biosynthesis; L-serine from
CC 3-phospho-D-glycerate: step 3/3. {ECO:0000256|ARBA:ARBA00005135}.
CC -!- SIMILARITY: Belongs to the HAD-like hydrolase superfamily. SerB family.
CC {ECO:0000256|ARBA:ARBA00009184}.
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DR EMBL; KQ257453; KND02567.1; -; Genomic_DNA.
DR RefSeq; XP_016610606.1; XM_016751309.1.
DR AlphaFoldDB; A0A0L0HNC3; -.
DR STRING; 645134.A0A0L0HNC3; -.
DR GeneID; 27686572; -.
DR VEuPathDB; FungiDB:SPPG_03024; -.
DR eggNOG; KOG1161; Eukaryota.
DR eggNOG; KOG1615; Eukaryota.
DR InParanoid; A0A0L0HNC3; -.
DR OMA; ARHPCDI; -.
DR OrthoDB; 789at2759; -.
DR UniPathway; UPA00135; UER00198.
DR Proteomes; UP000053201; Unassembled WGS sequence.
DR GO; GO:0036424; F:L-phosphoserine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006564; P:L-serine biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd07500; HAD_PSP; 1.
DR CDD; cd14447; SPX; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR004469; PSP.
DR InterPro; IPR004331; SPX_dom.
DR NCBIfam; TIGR01488; HAD-SF-IB; 1.
DR NCBIfam; TIGR00338; serB; 1.
DR PANTHER; PTHR43344; PHOSPHOSERINE PHOSPHATASE; 1.
DR PANTHER; PTHR43344:SF2; PHOSPHOSERINE PHOSPHATASE; 1.
DR Pfam; PF13740; ACT_6; 1.
DR Pfam; PF00702; Hydrolase; 1.
DR SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR SFLD; SFLDF00029; phosphoserine_phosphatase; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
DR PROSITE; PS51382; SPX; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00023299};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053201};
KW Serine biosynthesis {ECO:0000256|ARBA:ARBA00023299}.
FT DOMAIN 1..158
FT /note="SPX"
FT /evidence="ECO:0000259|PROSITE:PS51382"
FT ACT_SITE 423
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR604469-1"
FT ACT_SITE 425
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR604469-1"
SQ SEQUENCE 637 AA; 70956 MW; A044C8DB3CA704A0 CRC64;
MKFGKYLTER RKTLPPKWAD SCIDYVLLKN HVKQHVKPYG LTSSLPSSLE DKPFADVFLS
RSSKLQAAVA EFFQLLDKEI DRFAALYEAE CDDLAKRFES RGVVNGTGHD EGKSSANQML
QDLVKLEKYV FLNYTGITKI LKKNDRHSGF RLSEHYILRL STKPFYRSEE LSLLKKRLID
EVSGTSSPLI HTPNPPLSPI VTDKGLSLPS SIGSQTQSRS WFPPASLLPQ QKVLVTMTGP
HGTDIIGAVL ENLARYKCEI DDFVLSRLYH NVTFGCLIRL ASENVDIFRD LAESARKWDA
TLFFDVQDAT KGDPVGSSLE DAPYENRLKY TATVLNQNGL TSRFLHAWTR LLLDEKISVE
KMTRLSASGA KLCSVEYRLS VPAEVDFDLF RATLFQMSSE HGTDVALQPN DVYRKHKRLV
IFDMDSTLIQ QEVIDEIAKH AGVVAEVAKI TESAMNGEID FKESLRRRVG LLKGTPASVL
EHVKTQLTFT EGAHFLCRAL KRLGFKLAVI SGGFMPLALH VKNQLGLDYA FANQLKVSPD
GQTLTGETVG PIVDGMRKAE LLEVIAQAES VTPEQVIAVG DGANDLWMLA AAGLGIAFNA
KPRVQKEARA RINQTSLRNV LYLLGYTDDD AKQLAEM
//
