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Database: UniProt
Entry: A0A0L0J6M7_9RHOB
LinkDB: A0A0L0J6M7_9RHOB
Original site: A0A0L0J6M7_9RHOB 
ID   A0A0L0J6M7_9RHOB        Unreviewed;       295 AA.
AC   A0A0L0J6M7;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   22-NOV-2017, entry version 15.
DE   RecName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000256|RuleBase:RU910714};
DE            Short=HIBADH {ECO:0000256|RuleBase:RU910714};
DE            EC=1.1.1.31 {ECO:0000256|RuleBase:RU910714};
GN   ORFNames=APZ00_22065 {ECO:0000313|EMBL:ALV29394.1};
OS   Pannonibacter phragmitetus.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhodobacterales;
OC   Rhodobacteraceae; Pannonibacter.
OX   NCBI_TaxID=121719 {ECO:0000313|EMBL:ALV29394.1, ECO:0000313|Proteomes:UP000064921};
RN   [1] {ECO:0000313|EMBL:ALV29394.1, ECO:0000313|Proteomes:UP000064921}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=31801 {ECO:0000313|EMBL:ALV29394.1,
RC   ECO:0000313|Proteomes:UP000064921};
RA   Ming D., Wang M., Zhou Y., Jiang T., Hu S.;
RT   "The world's first case of liver abscess caused by Pannonibacter
RT   phragmitetus.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: 3-hydroxy-2-methylpropanoate + NAD(+) = 2-
CC       methyl-3-oxopropanoate + NADH. {ECO:0000256|RuleBase:RU910714}.
CC   -!- PATHWAY: Amino-acid degradation; L-valine degradation.
CC       {ECO:0000256|RuleBase:RU910714}.
CC   -!- SIMILARITY: Belongs to the 3-hydroxyisobutyrate dehydrogenase
CC       family. {ECO:0000256|RuleBase:RU910714}.
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DR   EMBL; CP013068; ALV29394.1; -; Genomic_DNA.
DR   RefSeq; WP_050471304.1; NZ_LGSQ01000001.1.
DR   EnsemblBacteria; ALV29394; ALV29394; APZ00_22065.
DR   GeneID; 34093153; -.
DR   KEGG; pphr:APZ00_22065; -.
DR   PATRIC; fig|121719.5.peg.552; -.
DR   KO; K00020; -.
DR   UniPathway; UPA00362; -.
DR   Proteomes; UP000064921; Chromosome.
DR   GO; GO:0008442; F:3-hydroxyisobutyrate dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0004616; F:phosphogluconate dehydrogenase (decarboxylating) activity; IEA:InterPro.
DR   GO; GO:0006574; P:valine catabolic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR002204; 3-OH-isobutyrate_DH-rel_CS.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR006115; 6PGDH_NADP-bd.
DR   InterPro; IPR011548; HIBADH.
DR   InterPro; IPR015815; HIBADH-related.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR029154; NADP-bd.
DR   Pfam; PF14833; NAD_binding_11; 1.
DR   Pfam; PF03446; NAD_binding_2; 1.
DR   PIRSF; PIRSF000103; HIBADH; 1.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR01692; HIBADH; 1.
DR   PROSITE; PS00895; 3_HYDROXYISOBUT_DH; 1.
PE   3: Inferred from homology;
KW   Branched-chain amino acid catabolism {ECO:0000256|RuleBase:RU910714};
KW   Complete proteome {ECO:0000313|Proteomes:UP000064921};
KW   NAD {ECO:0000256|RuleBase:RU910714};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU910714};
KW   Reference proteome {ECO:0000313|Proteomes:UP000064921}.
FT   DOMAIN        4    162       NAD_binding_2. {ECO:0000259|Pfam:
FT                                PF03446}.
FT   DOMAIN      165    292       NAD_binding_11. {ECO:0000259|Pfam:
FT                                PF14833}.
FT   ACT_SITE    171    171       {ECO:0000256|PIRSR:PIRSR000103-1}.
SQ   SEQUENCE   295 AA;  29594 MW;  19CE30BF7C3A6D14 CRC64;
     MASVGFIGLG NMGGPMAANL VRAGHAVKGF DLSPEAKAQL EAAGGKAVAS VAEAVRDADA
     VVSMLPAGKH VRAVYTGEEG VLASARPGTL LIDSSTIDVD SARAVAQAAA SAGMVMVDAP
     VSGGVGGAAA GTLTFMVGGE DAAFERAKPF LEVMGKTIVH AGGSGTGQAA KICNNMILGI
     SMIAVSEAFI LAERLGLDAQ KLFDISSTAS GQCWSLTSYC PVPGPVPSSP ANRDYQPGFA
     AQMMLKDLKL SQEAAQSSGA ATPLGAQAAA LYALFCNSGH AGTDFSGIVR FLRGE
//
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