ID   A0A0L0JHN8_9ACTN        Unreviewed;       708 AA.
AC   A0A0L0JHN8;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=Squalene-hopene cyclase {ECO:0000313|EMBL:KND25108.1};
GN   ORFNames=IQ63_41465 {ECO:0000313|EMBL:KND25108.1};
OS   Streptomyces acidiscabies.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=42234 {ECO:0000313|EMBL:KND25108.1, ECO:0000313|Proteomes:UP000037151};
RN   [1] {ECO:0000313|Proteomes:UP000037151}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCPPB 4445 {ECO:0000313|Proteomes:UP000037151};
RA   Harrison J., Sapp M., Thwaites R., Studholme D.J.;
RT   "Genome sequencing of plant-pathogenic Streptomyces species.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Secondary metabolite biosynthesis; hopanoid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00004999}.
CC   -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC       {ECO:0000256|ARBA:ARBA00009755}.
CC   -!- SIMILARITY: Belongs to the terpene synthase family.
CC       {ECO:0000256|ARBA:ARBA00006333}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KND25108.1}.
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DR   EMBL; JPPY01000231; KND25108.1; -; Genomic_DNA.
DR   RefSeq; WP_050375189.1; NZ_KQ257834.1.
DR   AlphaFoldDB; A0A0L0JHN8; -.
DR   PATRIC; fig|42234.21.peg.8517; -.
DR   OrthoDB; 9758578at2; -.
DR   UniPathway; UPA00337; -.
DR   Proteomes; UP000037151; Unassembled WGS sequence.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   InterPro; IPR006400; Hopene-cyclase.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR002365; Terpene_synthase_CS.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   NCBIfam; TIGR01507; hopene_cyclase; 1.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR   PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000037151};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          42..326
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          337..653
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
FT   REGION          660..708
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        679..695
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   708 AA;  77858 MW;  81FC057F25459FCA CRC64;
     MTATTDGSTG AALPHRAASA SETDITIPVA AGVQEAAERA MRRATDHLLA HQDAQGWWKG
     DLETNVTMDA EDLLLRQFLG IRDERTTQAS ALFVRGEQRE DGTWATFYGG PADLSATIEA
     YVALRLAGDD PGAPHMAKAS AWIRAQGGLA SARVFTRIWL ALFGWWKWED LPELPPELIY
     FPRWFPLSIY NFGCWARQTI VPLTVVSAKR PVRPAPFPLD ELHTDPSVPN PPKPLAPLAS
     WDGLFQRLDK VVRGYRPFAV RRLRRSALNS AARWIVERQE NDGCWGGIQP PAVYSVIALY
     LLGYDLEHPV MRAGLESLDR YAVWREDGAR MIEACQSPVW DTCLATIALA DAGVPADHPQ
     LVKAADWMLG EQIVRPGDWS VSRPQLPPGG WAFEFHNDNY PDIDDTAEVV LALRRVRHHD
     PERVEKAIAR GVRWNLGMQS RDGGWGAFDV DNTSPFPNRL PFCDFGEVID PPSADVTAHV
     VEMLAVEGLS HDPRTRRGIA WLLAEQEPDG SWFGRWGVNY VYGTGSVVPA LVAAGLPAQH
     PAIRRAVTWL EHVQNEDGGW GEDLRSYQES TKWAGSGDST ASQTGWALMA LLSAGERDSR
     AVERGIAWLA ETQREDGSWD EPYFTGTGFP WDFSINYHLY RQVFPLTALG RYVNGEPVFA
     RTPDTAQRGA GSGGRPSTGA GRGGTTVSAD SRGSREAPSA GSPEVKAS
//