ID A0A0L0JTF8_9ACTN Unreviewed; 854 AA.
AC A0A0L0JTF8;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=Beta-ketoacyl synthase {ECO:0000313|EMBL:KND28861.1};
GN ORFNames=IQ63_32575 {ECO:0000313|EMBL:KND28861.1};
OS Streptomyces acidiscabies.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=42234 {ECO:0000313|EMBL:KND28861.1, ECO:0000313|Proteomes:UP000037151};
RN [1] {ECO:0000313|Proteomes:UP000037151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCPPB 4445 {ECO:0000313|Proteomes:UP000037151};
RA Harrison J., Sapp M., Thwaites R., Studholme D.J.;
RT "Genome sequencing of plant-pathogenic Streptomyces species.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KND28861.1}.
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DR EMBL; JPPY01000183; KND28861.1; -; Genomic_DNA.
DR RefSeq; WP_050373817.1; NZ_KQ257831.1.
DR AlphaFoldDB; A0A0L0JTF8; -.
DR PATRIC; fig|42234.21.peg.6706; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000037151; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 1.10.1240.100; -; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000037151};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 5..431
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 746..822
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 829..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 854 AA; 89462 MW; B50C087A90F3F8FA CRC64;
MTVSDSDIAI IGMACRFPGA DSVDRFWEVL SEGRETLTRY TDEELTAAGV PADRLADPRY
VKAAQTIAGT DLFDSELFRF THDEAEILDP QHRVFLECAL EALERSGYDP ERTDAQIGVY
AGAGMNTYLL HNLGERYRGA SSVDRYRLML ANDKDFLSTR VSYKLDLTGP SVNISTACST
SLVSVHTACL ALLGGECDMA LVGAVHLNPP GEGYQYQEGM IFSPDGHCRA FDAQARGTVI
GSGAGAVVLK RLKEALADGD WIHAVIKGSA INNDGAAKTG YTAPSISGQA AVIADAHEVA
DVEPDTIGYV EAHGTGTPLG DPIEVAALTE AFRHGTERSG YCALGSVKTN VGHLDTAAGM
AGLIKTALML EHRTLVPSLH FTAPNPDIDF ASSPFFVNTA NTEWTSAEGP RRAGVSSFGI
GGTNAHVILQ EAPARSETSR EERPELLVLS ARSAEALKQA QGALARHLRA RRDLDLTAVA
QTLGLGRRAH AHRLALVADG TRGAAMALAL GDGEGIRRGV AGEVGPVLVL TGGAAPEARE
LYAAVPAYRE AVDACADAVG LVGGGEALLS GEYAGFCHEY GVVRALLSWG VAPGGLAGTG
AGLAVAAAVS EALVLPDALA LAVGSAPLRV SAPGLPVLSA VTGARLTQDP GDWTSGGPVA
DGAGWVRVSA AGYAELLALA GELWVRGGEL DFAALHEGRD VRRVPLPTHR FERRRHWVEP
GAQTGQPAAP ERDRLLARFE ADDPAHNVEL VTDFVTDEVG KVLGGRHLAA LDTNLFDLGL
DSLVLIEVVA KLGEELDFEV PATAFVEFPT IRSFVENLAE LMGLTEGGGA APAAAAGRTS
RRAQRAEARR AGQG
//
