ID A0A0L0KJB1_9ACTN Unreviewed; 562 AA.
AC A0A0L0KJB1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=3'-5' exonuclease {ECO:0000313|EMBL:KND38352.1};
GN ORFNames=IQ63_08325 {ECO:0000313|EMBL:KND38352.1};
OS Streptomyces acidiscabies.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=42234 {ECO:0000313|EMBL:KND38352.1, ECO:0000313|Proteomes:UP000037151};
RN [1] {ECO:0000313|Proteomes:UP000037151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCPPB 4445 {ECO:0000313|Proteomes:UP000037151};
RA Harrison J., Sapp M., Thwaites R., Studholme D.J.;
RT "Genome sequencing of plant-pathogenic Streptomyces species.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KND38352.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JPPY01000046; KND38352.1; -; Genomic_DNA.
DR RefSeq; WP_050370077.1; NZ_KQ257808.1.
DR AlphaFoldDB; A0A0L0KJB1; -.
DR PATRIC; fig|42234.21.peg.1718; -.
DR OrthoDB; 4414061at2; -.
DR Proteomes; UP000037151; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:InterPro.
DR CDD; cd06444; DNA_pol_A; 1.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR002298; DNA_polymerase_A.
DR PANTHER; PTHR10133; DNA POLYMERASE I; 1.
DR PANTHER; PTHR10133:SF62; DNA POLYMERASE THETA; 1.
DR Pfam; PF00476; DNA_pol_A; 1.
DR PRINTS; PR00868; DNAPOLI.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000313|EMBL:KND38352.1};
KW Hydrolase {ECO:0000313|EMBL:KND38352.1};
KW Nuclease {ECO:0000313|EMBL:KND38352.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000037151}.
FT DOMAIN 313..521
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
SQ SEQUENCE 562 AA; 60678 MW; BAD979EE4F430346 CRC64;
MSDRWVLVPG EGGGVEVAPL GGDGVLTGDV VREASVGEAV RKRGDVGRWV WRSSAEVYAG
VVAAGARVER CYDVEVAENL LLGHEGRFGS PKSAWAALAR LRGTAVPADL PVRAVEPGAQ
PSLFEPGEAR ARLSVGELVE VYRDQMRRHD LAEHPARMRL LTAAESAGTL VATEMNAAGL
PWRADVHRSV LGELLGERYA GGGEPRRLAE LADQVSTAFG RRVRPDLPAD VVKAFAQAGI
KVKSTRRWEI ETIDHPAVAP LIEYKKLYRI WVAHGWGWLQ DWVRDGRFRP EFLAGGTVTG
RWVTNGGGAL QIPKVIRRAV VADPGWRLVV ADADQMEPRI LAAISRDPGL MEVAGRASDL
YQEVSDRAFS GDRDQAKLAV LGAVYGQTSG DGLKNLAALR RRFPRAVEYV DEAARAGEEG
RLVRTWLGRT CPPAATGEDA EGTGDEAGIP VEESPSAWVP GYASTNARAR GRFTRNFVVQ
GSAADWALLL LAALRQACAG MAAELVFFQH DEVIVHCPED EAEAVVSAIR EASMLAARLT
FGETPVRFPF STAVVECYAD AK
//
