ID A0A0L0KNG4_9ACTN Unreviewed; 1270 AA.
AC A0A0L0KNG4;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Signal transduction histidine-protein kinase/phosphatase MprB {ECO:0000256|ARBA:ARBA00040454};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
DE AltName: Full=Mycobacterial persistence regulator B {ECO:0000256|ARBA:ARBA00041776};
GN ORFNames=IQ63_03175 {ECO:0000313|EMBL:KND39398.1};
OS Streptomyces acidiscabies.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=42234 {ECO:0000313|EMBL:KND39398.1, ECO:0000313|Proteomes:UP000037151};
RN [1] {ECO:0000313|Proteomes:UP000037151}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCPPB 4445 {ECO:0000313|Proteomes:UP000037151};
RA Harrison J., Sapp M., Thwaites R., Studholme D.J.;
RT "Genome sequencing of plant-pathogenic Streptomyces species.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KND39398.1}.
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DR EMBL; JPPY01000023; KND39398.1; -; Genomic_DNA.
DR RefSeq; WP_050369279.1; NZ_KQ257800.1.
DR AlphaFoldDB; A0A0L0KNG4; -.
DR PATRIC; fig|42234.21.peg.658; -.
DR OrthoDB; 4652229at2; -.
DR Proteomes; UP000037151; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004673; F:protein histidine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd06225; HAMP; 1.
DR Gene3D; 6.10.340.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003660; HAMP_dom.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR013587; Nitrate/nitrite_sensing.
DR InterPro; IPR010910; Nitrate/nitrite_sensing_bac.
DR PANTHER; PTHR44936; SENSOR PROTEIN CREC; 1.
DR PANTHER; PTHR44936:SF9; SENSOR PROTEIN RSTB; 1.
DR Pfam; PF00672; HAMP; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF08376; NIT; 1.
DR SMART; SM00304; HAMP; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR PROSITE; PS50885; HAMP; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50906; NIT; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022912};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000037151};
KW Stress response {ECO:0000256|ARBA:ARBA00023016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 398..420
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 128..390
FT /note="NIT"
FT /evidence="ECO:0000259|PROSITE:PS50906"
FT DOMAIN 421..491
FT /note="HAMP"
FT /evidence="ECO:0000259|PROSITE:PS50885"
FT DOMAIN 608..714
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT REGION 1..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 715..763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 808..1270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..68
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 850..869
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..899
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 939..954
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1033..1073
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1121..1141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1142..1163
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1214..1228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1251..1270
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1270 AA; 132578 MW; 6DEE8BA4CFE79C00 CRC64;
MQGRFKRDGS APAGPEPRGG TGAKTVSSSP QHAQNPGPAQ AGDGKSRPGA PTTPVTPTSI
PPIPPAKPVK GDSGNRVALR NWRISTRLVA LLTLPVVAAT TLGALRINQS MEDIQQLDNM
RLLTDMTKQA TELSIALQNE RDRSAGPLAH GGRADDATVK GLRTTTDRSL DAFVNASEEI
DATSKNGNLQ GVRDNLVGLV GDLGNLAKLR STAYTAQGNA MQTVEGYHRL ITRLVDLSQD
MAEATSNPEM IQRTRALAAF SSAKEYSSIQ RAVLTASLPA NNKVFGNLSD NDRNYGETAV
EGEDSELAIF RSIYGDEGAE ELLKPIESGN ATIEEADQYA NRAYASDSGL ESQDKRSYQD
WLDASGTKLQ QMRNIESQLL DDMEQKAREL RNETERDAII SGLLILMVLG VSLVGAFVVA
RSMIRSLRRL QETATKVAQE RLPELVKQLS ESDPQDVDTS VESVGVHSRD EIGQVAAAFD
DVHREAVRLA AEQALLRGNV NAMFTNLSRR SQGLIQRQLS LISELESREA DPDQLSSLFK
LDHLATRMRR NGENLLVLAG EEPGRRWTRP VPLVDVLRAA ASEVEQYERI ELSSVPTTEV
AGRVVNDLVH LLAELLENAT SFSSPQTKVK VTGHALPDGR VLIEIHDTGI GLSPEDLAAI
NERLASPPTV DVSVSRRMGL FVVGRLSQRH GIRIQLRPSD SGGTTALVML PVDVAQGGKK
PQPKPGQGGA QAGGPVAAQA AAGAAAARRQ GGPGQGAAGA FGGGPGGGKG AGFGPGPAGQ
GSGAGAFGGG GAFGAGSGAG AGFGAGPGGG ALGGGPRTAL PGRDGAPARG QQQGGRPSAP
APAGTGSFNG LQAAPPQGQP GQQQGQDMFG GGSRPPRGKD SRGGQDSRGG QDSRGGKGEQ
GRGRQPQLPP RGGARAELPG GNSQPRTPSW GDENARPPAL DAPRGHDEPD VARTSQMPRI
EGPGSTAEIP RVEGDFGRAN VNGAQHTGQF PALGAPAPQG NRRGAQDDFQ ATSQFPAIGG
GQPGDAGGQF GRTEQEPVNN ANNMDNSGQF VRTDVFGTNP VPNTPQDTGQ FPARQQGYDA
LPGRANANGY AAPQRPAVRP EPEALPPAGP GDGRTPLYDT LETNWFHQQG GQTQGVPQQP
QAQAPAPAPT PAPAPPAPAA PQRPAAAPAA TASSSWRATP NDDLVRQAER VRQPASGGIT
TSGLPRRVPR ANLVPGTAQQ QQHQAGPQVS RAPDDVRGRL TNLRRGIAQG RQAGSGQTDS
FPSPTHQQER
//