ID A0A0L0LKY1_9BACT Unreviewed; 693 AA.
AC A0A0L0LKY1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
GN Name=gyrB {ECO:0000313|EMBL:KND51067.1};
GN ORFNames=AB202_01490 {ECO:0000313|EMBL:KND51067.1};
OS Parcubacteria bacterium C7867-007.
OC Bacteria; Candidatus Parcubacteria.
OX NCBI_TaxID=1659201 {ECO:0000313|EMBL:KND51067.1, ECO:0000313|Proteomes:UP000037534};
RN [1] {ECO:0000313|EMBL:KND51067.1, ECO:0000313|Proteomes:UP000037534}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C7867-007 {ECO:0000313|EMBL:KND51067.1};
RX PubMed=26257709; DOI=10.3389/fmicb.2015.00713;
RA Nelson W.C., Stegen J.C.;
RT "The reduced genomes of Parcubacteria (OD1) contain signatures of a
RT symbiotic lifestyle.";
RL Front. Microbiol. 6:713-713(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the type II topoisomerase GyrB family.
CC {ECO:0000256|ARBA:ARBA00010708}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KND51067.1}.
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DR EMBL; LFCQ01000003; KND51067.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0LKY1; -.
DR STRING; 1659201.AB202_01490; -.
DR PATRIC; fig|1659201.3.peg.291; -.
DR Proteomes; UP000037534; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd16928; HATPase_GyrB-like; 1.
DR CDD; cd00822; TopoII_Trans_DNA_gyrase; 1.
DR CDD; cd03366; TOPRIM_TopoIIA_GyrB; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.670; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR002288; DNA_gyrase_B_C.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR001241; Topo_IIA.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR000565; Topo_IIA_B.
DR InterPro; IPR013759; Topo_IIA_B_C.
DR InterPro; IPR013506; Topo_IIA_bsu_dom2.
DR InterPro; IPR018522; TopoIIA_CS.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034160; TOPRIM_GyrB.
DR PANTHER; PTHR45866:SF1; DNA GYRASE SUBUNIT B, MITOCHONDRIAL; 1.
DR PANTHER; PTHR45866; DNA GYRASE/TOPOISOMERASE SUBUNIT B; 1.
DR Pfam; PF00204; DNA_gyraseB; 1.
DR Pfam; PF00986; DNA_gyraseB_C; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR01159; DNAGYRASEB.
DR PRINTS; PR00418; TPI2FAMILY.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00433; TOP2c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
DR PROSITE; PS00177; TOPOISOMERASE_II; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235, ECO:0000313|EMBL:KND51067.1};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 450..564
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT REGION 596..618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 693 AA; 75902 MW; 9BE4C809F24DF01F CRC64;
MAKEGDKTTK KAAKSGDYDA SSITVLEGLD PVRKRPGMYI GTTGPDGLHH LIWEIFDNSR
DEAMGGFADD IEITLLPGGY VRVVDNGRGI PVGIHPKTKV SALETIMTTL HAGGKFGGED
SGYKVSGGLH GVGASVVNAL SEHAKVIVHK EGATHMQEYK IGKAMAKVKQ IGKTKHQGSV
VFFKPDVSIF KDGINWNWDR IVGHIRQQAY LVKGTRMCVI DAREAGMVDS EEVAYVRELG
LEVPTMTFFF ENGLRSLVAF TNKHQAPAHK NIFYVDATEN EVMVEVAFQY TDDISPRLLA
FANNTYNPEH GTHVTGFKTA LTRTLNTYAR TAGILKESEE NFTGDDVLEG ITAVVSVKMP
EIQFEGQTKG KLGSVEAQGA VATVFGGALN TFLEENPDDG RAIVNKVLLA LKARKAAKAA
KDSVLRKGAL EGMTLPGKLA DCQTKDPAES EIFIVEGDSA GGSAKTGRDR RTQAILPLRG
KILNIERARL DKMLASEQIK NLVVAMGTAI GDIFDISKLR YHKIIIATDA DVDGAHIRTL
LLTLFYRHFR PIIDGGFIYI AQPPLYKIKR GKEVMYAYTD EEKFRILGPD AEMAVEASDE
AQGTEEDGDE TPEEELTTKK GMKVSIQRYK GLGEMNPEEL WETTMNPSNR VLKRVTIEDA
TDADRIFDIL MGSDVPSRKS FIQSNAKLAN LDV
//
