ID A0A0L0LKY4_9BACT Unreviewed; 493 AA.
AC A0A0L0LKY4;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Translation initiation factor IF-2 {ECO:0000256|ARBA:ARBA00020675, ECO:0000256|RuleBase:RU000644};
GN Name=infB {ECO:0000313|EMBL:KND50798.1};
GN ORFNames=AB202_00115 {ECO:0000313|EMBL:KND50798.1};
OS Parcubacteria bacterium C7867-007.
OC Bacteria; Candidatus Parcubacteria.
OX NCBI_TaxID=1659201 {ECO:0000313|EMBL:KND50798.1, ECO:0000313|Proteomes:UP000037534};
RN [1] {ECO:0000313|EMBL:KND50798.1, ECO:0000313|Proteomes:UP000037534}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C7867-007 {ECO:0000313|EMBL:KND50798.1};
RX PubMed=26257709; DOI=10.3389/fmicb.2015.00713;
RA Nelson W.C., Stegen J.C.;
RT "The reduced genomes of Parcubacteria (OD1) contain signatures of a
RT symbiotic lifestyle.";
RL Front. Microbiol. 6:713-713(2015).
CC -!- FUNCTION: One of the essential components for the initiation of protein
CC synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis
CC and promotes its binding to the 30S ribosomal subunits. Also involved
CC in the hydrolysis of GTP during the formation of the 70S ribosomal
CC complex. {ECO:0000256|RuleBase:RU000644}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. IF-2 subfamily.
CC {ECO:0000256|ARBA:ARBA00007733, ECO:0000256|RuleBase:RU000644}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KND50798.1}.
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DR EMBL; LFCQ01000003; KND50798.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0LKY4; -.
DR STRING; 1659201.AB202_00115; -.
DR PATRIC; fig|1659201.3.peg.18; -.
DR Proteomes; UP000037534; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW.
DR CDD; cd01887; IF2_eIF5B; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR Gene3D; 3.40.50.10050; Translation initiation factor IF- 2, domain 3; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR000178; TF_IF2_bacterial-like.
DR InterPro; IPR015760; TIF_IF2.
DR InterPro; IPR023115; TIF_IF2_dom3.
DR InterPro; IPR036925; TIF_IF2_dom3_sf.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR NCBIfam; TIGR00487; IF-2; 1.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43381:SF5; TR-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR43381; TRANSLATION INITIATION FACTOR IF-2-RELATED; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF11987; IF-2; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF52156; Initiation factor IF2/eIF5b, domain 3; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 2.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000256|RuleBase:RU000644};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU000644}.
FT DOMAIN 5..178
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 493 AA; 52404 MW; 215AF38519772DBF CRC64;
MAVAPRPPIV AVMGHIDHGK SSLLDYIRKS NVAAGEAGGI TQHVSAYEVV HEHEGAPRTI
TFLDTPGHEA FRVLRARGAT AADVAILVIA AEEGVKPQTL EAYEAIMEAG TPFVVAFTKI
DKNSADIERA KMSTIEHGIY LEGLGGSISY TGVSSKTGEG VPELLDLVLL TADFAELTAD
SSKTAEGFIL ESSQDPRQGM TATLIIKDGS LSTGSFVVAG SAIAPVRFIE DFKGDRIDTA
LPSQPVLIAG WSSLPPAGTP FAAAASKKDA EKLATEKVVI ANIPAKALET EDGKRVLPII
LKADVTGSLE AIKHELNKIQ HDRVAIRVIV EGVGAVSEGD VKQAQASGAI VIGFTVGTDN
SARELAERAA ILIESFKIIY ELKERIEQLV KEHAPRITTE ELTGQAKVLK TFNASSGKVV
LGARWESGIL TPKSQVKIER RGIPLGQGRI TNLQVARMDV QEIKVEGEFG LQIETKVDIA
GGDTLITFRV VES
//
