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Database: UniProt
Entry: A0A0L0M094_9BURK
LinkDB: A0A0L0M094_9BURK
Original site: A0A0L0M094_9BURK 
ID   A0A0L0M094_9BURK        Unreviewed;       432 AA.
AC   A0A0L0M094;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   13-FEB-2019, entry version 17.
DE   RecName: Full=Homoserine dehydrogenase {ECO:0000256|RuleBase:RU000579};
DE            EC=1.1.1.3 {ECO:0000256|RuleBase:RU000579};
GN   ORFNames=BPUN_1968 {ECO:0000313|EMBL:KND55701.1};
OS   Candidatus Paraburkholderia kirkii.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Paraburkholderia.
OX   NCBI_TaxID=198822 {ECO:0000313|EMBL:KND55701.1, ECO:0000313|Proteomes:UP000053677};
RN   [1] {ECO:0000313|Proteomes:UP000053677}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UZHbot2 {ECO:0000313|Proteomes:UP000053677};
RA   Carlier A., Eberl L., Pinto-Carbo M.;
RT   "Comparative genomics of Burkholderia leaf nodule symbionts.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-homoserine + NADP(+) = H(+) + L-aspartate 4-
CC         semialdehyde + NADPH; Xref=Rhea:RHEA:15761, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:57476, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC         ChEBI:CHEBI:537519; EC=1.1.1.3;
CC         Evidence={ECO:0000256|RuleBase:RU000579};
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC       {ECO:0000256|RuleBase:RU000579}.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004171}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KND55701.1}.
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DR   EMBL; LFKV01000013; KND55701.1; -; Genomic_DNA.
DR   EnsemblBacteria; KND55701; KND55701; BPUN_1968.
DR   PATRIC; fig|198822.17.peg.2030; -.
DR   UniPathway; UPA00050; UER00063.
DR   UniPathway; UPA00051; UER00465.
DR   Proteomes; UP000053677; Unassembled WGS sequence.
DR   GO; GO:0004412; F:homoserine dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR002912; ACT_dom.
DR   InterPro; IPR005106; Asp/hSer_DH_NAD-bd.
DR   InterPro; IPR016204; HDH.
DR   InterPro; IPR001342; HDH_cat.
DR   InterPro; IPR019811; HDH_CS.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01842; ACT; 1.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PIRSF; PIRSF000098; Homoser_dehydrog; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   PROSITE; PS51671; ACT; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Branched-chain amino acid biosynthesis
KW   {ECO:0000256|RuleBase:RU000579}; Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053677};
KW   Isoleucine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   Methionine biosynthesis {ECO:0000256|RuleBase:RU000579};
KW   NADP {ECO:0000256|PIRSR:PIRSR000098-2, ECO:0000256|RuleBase:RU000579};
KW   Oxidoreductase {ECO:0000256|RuleBase:RU000579,
KW   ECO:0000313|EMBL:KND55701.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053677};
KW   Threonine biosynthesis {ECO:0000256|RuleBase:RU000579}.
FT   DOMAIN      347    428       ACT. {ECO:0000259|PROSITE:PS51671}.
FT   NP_BIND       1      8       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   COILED      399    419       {ECO:0000256|SAM:Coils}.
FT   ACT_SITE    197    197       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000098-1}.
FT   BINDING      97     97       NADP. {ECO:0000256|PIRSR:PIRSR000098-2}.
FT   BINDING     182    182       Substrate. {ECO:0000256|PIRSR:
FT                                PIRSR000098-2}.
SQ   SEQUENCE   432 AA;  46183 MW;  85692ED358B9D9DC CRC64;
     MGFGTVGSGT FTVLRRNQEE IKRRAGRGIE IARVAVRTPA KAAAAKQEDI AVTDDFNAVV
     DDPAISIVCE MIGGTGFARE LVLRAIANGK HVVTANKALL AVHGTEIFEA ARTKGVMVAF
     EAAVAGGIPI IKALREGLTA NRIEYIAGII NGTTNYILSE MRDRGLDFAT ALKAAQELGY
     AEADPTFDVE GVDAAHKVTI MSAIAFGVPV QFDRAYVEGI SKLAAIDIRY AEDLGYRIKL
     LGIARRTEKG IELRTHPTLI PARRLLANVE GAMNAVVVHG DAVGTTLYYG KGAGSEPTAS
     AVVADLVDVT RLHTADPEHR VPHLAFQPDS LSNTPILPID EVTSGYYLRL RVADVTGVLA
     NITRILADKA ISIDALLQKE SEEVDGANKG ETDIILITHE TLEKNVNAAI EEIEALSTVV
     SKVTKLRMEA LN
//
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