ID A0A0L0MDP3_9BURK Unreviewed; 758 AA.
AC A0A0L0MDP3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Tyrosine-protein kinase Wzc {ECO:0000313|EMBL:KND60421.1};
DE EC=2.7.10.2 {ECO:0000313|EMBL:KND60421.1};
GN ORFNames=BVER_03876c {ECO:0000313|EMBL:KND60421.1};
OS Candidatus Burkholderia verschuerenii.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Burkholderiaceae; Burkholderia.
OX NCBI_TaxID=242163 {ECO:0000313|EMBL:KND60421.1, ECO:0000313|Proteomes:UP000036959};
RN [1] {ECO:0000313|Proteomes:UP000036959}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UZHbot4 {ECO:0000313|Proteomes:UP000036959};
RA Carlier A., Eberl L., Pinto-Carbo M.;
RT "Comparative genomics of Burkholderia leaf nodule symbionts.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00001074};
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004429}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004429}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the etk/wzc family.
CC {ECO:0000256|ARBA:ARBA00008883}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KND60421.1}.
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DR EMBL; LFJJ01000063; KND60421.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0MDP3; -.
DR PATRIC; fig|242163.4.peg.6080; -.
DR OrthoDB; 9808257at2; -.
DR Proteomes; UP000036959; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0045226; P:extracellular polysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05387; BY-kinase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR025669; AAA_dom.
DR InterPro; IPR032807; GNVR.
DR InterPro; IPR003856; LPS_length_determ_N_term.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005702; Wzc-like_C.
DR NCBIfam; TIGR01007; eps_fam; 1.
DR PANTHER; PTHR32309; TYROSINE-PROTEIN KINASE; 1.
DR PANTHER; PTHR32309:SF13; TYROSINE-PROTEIN KINASE ETK-RELATED; 1.
DR Pfam; PF13614; AAA_31; 1.
DR Pfam; PF13807; GNVR; 1.
DR Pfam; PF02706; Wzz; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell inner membrane {ECO:0000256|ARBA:ARBA00022519};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KND60421.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000036959};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KND60421.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT TRANSMEM 44..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 28..121
FT /note="Polysaccharide chain length determinant N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02706"
FT DOMAIN 402..481
FT /note="Tyrosine kinase G-rich"
FT /evidence="ECO:0000259|Pfam:PF13807"
FT DOMAIN 562..686
FT /note="AAA"
FT /evidence="ECO:0000259|Pfam:PF13614"
FT REGION 82..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 82..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 758 AA; 83665 MW; 72A3E3E79D3E7AE2 CRC64;
MRHNQSIRRM NEPEDLYYVQ SSEREPDTMN LPSVFDVALD NKRMIAIVAA CFVAVGALYS
VLHAPVYRGD LVVQLEDSMS PPVTGPLNSQ TAVPGGDTKS KTDGEIQLLE SRTVLSQAVD
NTHLFVDAKP HYFPLIGRWI AAHSDGLSSP GIFGLGGYAW GTESIDVPQF DVPQKMEDDK
FYLRVLPGNK YQLDGKDLDK PVEGQVGKTL KFKTDAGEIT LFVAKLEGRP GAEFDLKRQS
RLVTIQDLQD QIDVKERGKE SDIIGASYDG TDPVLVAGVL NEVGRQYLAQ NVRRKTEEAQ
RSIDFLQSQI PLRAESLRRA EDDYNHTRAQ LSSVSLGDEA SMLLRQSVDA DSQLAALRQK
RLELSARYGP NHPDIQALNA QIADLGARST MLNDRIKVRP MIEQDILRKT RDVQVNQQLY
MTLQDNLQEM QLVKAGMAGS ARIVDWAPIP EKPIWPRMLI VLPLSALAGL FIGFGAALLR
SRLFRGVSDS RDIERTVGLD VYATVPNSVM QKRLEKRMDK TPGATTLLAA CSPRDPAIES
LRSFRAALQH MVGETVNNRV MFTSSRASVG KSFVAANSAA LLASPNRRVL LVDADIRNGM
IHHRLGLKRQ YGFADLLESG DVQRAIQHTS IEYLDFISAG TEGMDADLLL QSPFLEKLLE
ELSSRYDIVV IDTPPTLEVA DSASLAPNCA SVFLVTLAGV TKMSELEESV KRLRQVGVTP
TGSIFNRVTP TFGKYGYGEY GANRSTPAKG ARVTPELR
//