ID A0A0L0QUS4_VIRPA Unreviewed; 473 AA.
AC A0A0L0QUS4;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Sodium:proton antiporter {ECO:0000313|EMBL:KNE22430.1};
GN ORFNames=AFK71_02080 {ECO:0000313|EMBL:KNE22430.1};
OS Virgibacillus pantothenticus.
OC Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Virgibacillus.
OX NCBI_TaxID=1473 {ECO:0000313|EMBL:KNE22430.1, ECO:0000313|Proteomes:UP000036780};
RN [1] {ECO:0000313|Proteomes:UP000036780}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 26 {ECO:0000313|Proteomes:UP000036780};
RA Liu B., Wang J., Zhu Y., Liu G., Chen Q., Chen Z., Lan J., Che J., Ge C.,
RA Shi H., Pan Z., Liu X.;
RT "Fjat-10053 dsm26.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the NhaC Na(+)/H(+) (TC 2.A.35) antiporter
CC family. {ECO:0000256|ARBA:ARBA00038435}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNE22430.1}.
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DR EMBL; LGTO01000002; KNE22430.1; -; Genomic_DNA.
DR RefSeq; WP_050349904.1; NZ_LGTO01000002.1.
DR AlphaFoldDB; A0A0L0QUS4; -.
DR GeneID; 66869324; -.
DR PATRIC; fig|1473.5.peg.3338; -.
DR OrthoDB; 9762978at2; -.
DR Proteomes; UP000036780; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR InterPro; IPR004770; Na/H_antiport_NhaC.
DR InterPro; IPR018461; Na/H_Antiport_NhaC-like_C.
DR NCBIfam; TIGR00931; antiport_nhaC; 1.
DR PANTHER; PTHR33451; MALATE-2H(+)/NA(+)-LACTATE ANTIPORTER; 1.
DR PANTHER; PTHR33451:SF6; NA(+)_H(+) ANTIPORTER NHAC; 1.
DR Pfam; PF03553; Na_H_antiporter; 1.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000036780};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 38..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..93
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 197..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 266..290
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 310..335
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 347..369
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 430..451
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 162..454
FT /note="Na+/H+ antiporter NhaC-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03553"
SQ SEQUENCE 473 AA; 49789 MW; 48B0F69262E66D48 CRC64;
MYRIKAVQAT PLWEAIMMTV FIVCIISASI IFLEAAPHIP LILSLLTLCI YGLAKGNSYK
VLEQGIVEGA KSGMGAIFIF FFIGILIAAW MMGGTIPTLM YAGFGLVAPS FYFAIVFVVT
ALIGVVVGSS LTTIATVGVA FIGVSGAVDV SLAITAGAIV SGAFFGDKMS PLSDTTNMAS
STLQVDLFAH IKNMMGTTVP AFLISLLIFL IISPNLTEAN FGKMNEFQSG LLDTGLVHWA
NGVIPLLVLL VLSVKKVPAI LTLTGGSLAA IVMAYFHSAP SIGNLFAILM DGFVSETGVE
GIDSLLTRGG INGMLFTISL VLLALSMGGL LFTLGIIPRL LASIDHLLNK VFSVILASAT
TAIGINVLIG EQYLSILLTG ETYQSRYARV GLSNKNLSRV AEDAGTVINP LVPWSVCGVF
ITSVLGVSTL AYLPFAFFCV LSPLLTVLYG YTGWTLTYKK PEVGANSSEA TGT
//
