ID A0A0L0S143_ALLM3 Unreviewed; 1305 AA.
AC A0A0L0S143;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Rap-GAP domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AMAG_02097 {ECO:0000313|EMBL:KNE56268.1};
OS Allomyces macrogynus (strain ATCC 38327) (Allomyces javanicus var.
OS macrogynus).
OC Eukaryota; Fungi; Fungi incertae sedis; Blastocladiomycota;
OC Blastocladiomycetes; Blastocladiales; Blastocladiaceae; Allomyces.
OX NCBI_TaxID=578462 {ECO:0000313|EMBL:KNE56268.1, ECO:0000313|Proteomes:UP000054350};
RN [1] {ECO:0000313|EMBL:KNE56268.1, ECO:0000313|Proteomes:UP000054350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 38327 {ECO:0000313|EMBL:KNE56268.1,
RC ECO:0000313|Proteomes:UP000054350};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Heiman D., Howarth C., Larimer J., Lui A., MacDonald P.J.P.,
RA McCowen C., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "Annotation of Allomyces macrogynus ATCC 38327.";
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 38327 {ECO:0000313|Proteomes:UP000054350};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Borenstein D., Chen Z.,
RA Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B., Mehta T.,
RA Park D., Pearson M., Roberts A., Saif S., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Burger G., Gray M.W.,
RA Holland P.W.H., King N., Lang F.B.F., Roger A.J., Ruiz-Trillo I.,
RA Lander E., Nusbaum C.;
RT "The Genome Sequence of Allomyces macrogynus strain ATCC 38327.";
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG745330; KNE56268.1; -; Genomic_DNA.
DR STRING; 578462.A0A0L0S143; -.
DR EnsemblFungi; KNE56268; KNE56268; AMAG_02097.
DR VEuPathDB; FungiDB:AMAG_02097; -.
DR eggNOG; KOG3686; Eukaryota.
DR OrthoDB; 7294at2759; -.
DR Proteomes; UP000054350; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08368; LIM; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 1.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR15711:SF32; RAP GTPASE ACTIVATING PROTEIN 1, ISOFORM H; 1.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00412; LIM; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SMART; SM00132; LIM; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW LIM domain {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000054350};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 34..95
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 891..1130
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 178..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1141..1219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1273..1305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..228
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..279
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..369
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1305 AA; 136681 MW; E7C84D8FEB8D91AC CRC64;
MPLPRRETPA PVPHAGTHAL PSALTGMPRT HAATACAGCG ETIMAFEPYF AFDAMIYHQK
CFNCSRCHRP LAMDNVLAFN GDIFCTKHNP AAGPPPAPLS SASTAKRFFF RRPASFLTKS
ASAVTNAPPP PVPAQVPRHA ETVVSPTLSS ASAHVHWDPE ATYAAPFAQI TRRLSPVATD
RAAAPPSITG VSPSIMGASP PGRATPGSTH TSSTSSSSSL SWSRRYRTHA STAAAAAAAA
EPPGLPTVAP LSTSRPTSPL SQPWDEDDHV PHPRMNVEDD AHPLGPSQTR ARAGSASNLR
SRFPSAASVS AVSLISLFQK SGGGGAGSGK DSPATPAPYP DYDDEDGDED DEFDGHNGDD
DDDEEDDDVH DDDGHHHRRR HRHSHHPHLA RTDTLPSPPV DARYTPPNTY APSALAASSL
VGAVGTGSGT RLPDPCPTPP DPSPSASPRT AVSTGGDFKR LPPRSTSFAF GTAPSAHPHA
RTLPGVDEGD DDDENEYDTS AVPVAGDDGD LPPRPPRDPD HVLARHLARM ALGHPGAAGV
HGADPAALKA SSPTRATVGI VARRSITRSR SQDLDVVGDE VAAAVAAPQR RAQFTHLKKQ
RAQSMGAVAS IWTAGAAPAL PDLIYRTDGF VVETPPPRAV PIFGMAPASA PLAGPPQEDW
GMAIRPPPLP TSPQIAHEFV SSAASVASVH SNGGGSVVSQ ATAAAAESVS ARSPHASVRS
RGTNPYLVSD ARLNAMLVDY AHVEYSPYPG APPTLLDQVD VTAMYYRQYF AGHDHNNYVM
VLDGAQGGSS GVAGAISAAM SMGGGSGSGN AASALDDGLT GPLVISVRHD VAAGVFRMLV
RSEDRDVRIE VPVSEVKARV KRHKDVIKYV YQRFPVHKLV KVRAKSLEAD LVKLDQMRLA
FGVKVGVLYM RRGQTDENDV FGNQTHSRAF DEFLDVLGDR VPLVGYQGFL GGLDNRHGLD
GPESVVGKCG HFDLMFHVST LLPYSPTDPQ QVQRKAKIGN DLVCVVYVDD FVPPPALAGA
DAHRVAALAD LAQVAPVFDP TMIQSHFLTV YLVVAPCVMD GVAGHRVAVV AQADVPSFGP
PLPPDGFFGD ATQLRHFLHA KIVNGEAAAF RAGKIARLHR RTREMMVRDL VTTLVKYGGY
DKPNATKNAK DDSCGDASDA VAANASPQPT RGSRGRGAVS EKPGDASALP PPPSTSRRGK
SRFRTQARQS VAPGAGDLAT LENPSAVTVT FPTEPADAVT SPTLATAVPA AAPPVGSPPR
PRGRGFFAAM LRRNPGAGNS ASASPPAPAN AAFVPETQYD GGGAA
//
