ID A0A0L0S711_ALLM3 Unreviewed; 4018 AA.
AC A0A0L0S711;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0000256|ARBA:ARBA00022197};
DE AltName: Full=Dynein heavy chain, cytosolic {ECO:0000256|ARBA:ARBA00033439};
GN ORFNames=AMAG_03967 {ECO:0000313|EMBL:KNE58388.1};
OS Allomyces macrogynus (strain ATCC 38327) (Allomyces javanicus var.
OS macrogynus).
OC Eukaryota; Fungi; Fungi incertae sedis; Blastocladiomycota;
OC Blastocladiomycetes; Blastocladiales; Blastocladiaceae; Allomyces.
OX NCBI_TaxID=578462 {ECO:0000313|EMBL:KNE58388.1, ECO:0000313|Proteomes:UP000054350};
RN [1] {ECO:0000313|EMBL:KNE58388.1, ECO:0000313|Proteomes:UP000054350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 38327 {ECO:0000313|EMBL:KNE58388.1,
RC ECO:0000313|Proteomes:UP000054350};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Heiman D., Howarth C., Larimer J., Lui A., MacDonald P.J.P.,
RA McCowen C., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "Annotation of Allomyces macrogynus ATCC 38327.";
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 38327 {ECO:0000313|Proteomes:UP000054350};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Borenstein D., Chen Z.,
RA Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B., Mehta T.,
RA Park D., Pearson M., Roberts A., Saif S., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Burger G., Gray M.W.,
RA Holland P.W.H., King N., Lang F.B.F., Roger A.J., Ruiz-Trillo I.,
RA Lander E., Nusbaum C.;
RT "The Genome Sequence of Allomyces macrogynus strain ATCC 38327.";
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG745333; KNE58388.1; -; Genomic_DNA.
DR STRING; 578462.A0A0L0S711; -.
DR EnsemblFungi; KNE58388; KNE58388; AMAG_03967.
DR VEuPathDB; FungiDB:AMAG_03967; -.
DR eggNOG; KOG3595; Eukaryota.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000054350; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054350}.
FT DOMAIN 2248..2283
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 735..762
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2820..2882
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4018 AA; 453812 MW; DEA46107AB69D2CE CRC64;
MYRAGPPDRG TNGRGAAGAD RSNGLDKMAA SGLADKASRM SDKDRNHLFP QILKRFSWTV
AAPYKEERHS RMTSDSIANN YSPAARDLCI KDIKPIPAIR PTGQPLNQRH PLDVIRGSRP
LTLDERIQHD YPHVEHAYST SDLEAPVVAD LYDEDPDNPN NQLSPLDRYW YYVQEGVPES
VVSKLDAESV RRIEMALPAP MTDAQTATFD KAVADLLAEV RASYNLAFKK SIVDYILLDA
DERKRLMIPR VPYPYQPKIA RAPFPWHDSM HATKQFVETN LFITNPVMRL LLVIFQKYRD
LVMFDMAVFS EATLPITLDE FRNVLRGQCQ AFRARVLNEW MADIVDMFLE TKDQWYSIAT
NAADTDLGFQ RLDAFFKSVA VLTSNQLWYW TERSLRVLED FFRRFQNPAS SSTTSSGGGL
DSSFFAVSLR LHNGQIRFEP ALNEIETTVM HVLEDMVATI NDVPRVETKL FTSLANERLY
LFSMKLSDAA IGDGKLMRGI IQRNCSAPQK HLLAFEKYRP LLTHKAEKRI EDFLREKTDL
DEYELEIKRL LKLIDEISSS PSIVRFSLVH LDTEALKLEL VGRANALVQK IIDQVSDMHR
KQNQAICDQY EKISAKMMKT PQDTEELVEL IKYVDQVKDK EIAMLRDEIA RGKKRLDLLL
NYAFMSEDEV KLNGVTFTWP ARILPIHDLS KKRMAQRKVK AQDELRDKQA HAVAALDECY
NEVSLFKDYG IVSELPEYLK KIKRLEAKMQ DLDATIRKIN AEEELMEWDK TPFEKYQRIV
DLLDPYKKLW ETVGAFQTEY AKWMSGPFLD LQAEAVDESV NTMWRTLFKL IKVFVDQAVP
RKVAEGIKNK IDKFKVHLPL ISVLRNPGLY QRHWDRMAQI VGHAIQPTPE TTLAKMIEFN
LGPLVPQLEQ VSEAATKEHS LQKALSKMKD EWAGLAFNCV DYRDTGTKIL SSLEEVQALL
DDQIVKVQTM RSSPFANPIE AEVEAWETKL LTVQEIIDEW LQVQATWLYL EPIFTSEDIM
AQMPSEGKKF KQVDRTWRDM MRTCSENPGI LTFTATPGLT QKLKESNVLL EEIQKGLNEY
LEKKRIAFPR FFFLSNDELL EILAETKDPT RVQPHLKKCF EGINSLTFHD DARIVAMCSA
EGEKVKFKEV VEPSAAKGAV EKWLLQVERV MQTSVQEQVG KAYKAYPESP REKWVLEWPG
QVVICVGQIF WTREVQDAIA SGGVRGLAAY KQVCIKQLGT IAELVRGELS AMARFTLSAL
VVIDVHARDV VAQLETAGTS SINDFEWLSQ LRYYWEHNDV QIKMMNATIK YGYEYLGNSG
RLVVTPLTDR CYRTLIGALD LNLGGAPEGP AGTGKTETTK DLAKAIAKQC VVFNCSDGLD
YIAMGKFFKG LASSGAWACF DEFNRIDLEV LSVVAQQVLT IQRAVAAKAK SLLFEGTTLS
LNPGCAVFIT MNPGYAGRSE LPDNLKALFR PVAMMVPDYA LIAEISLFSF GFVDARNLAR
KIVATYRLCS EQLSSQDHYD YGMRAVKAVL TAAGNLKLKM PNEDEQIVML RSITDVNLPK
FLEQDVPLFS AITADLFPKV TLPKLDYSKL LACIDKVMAR NNLQPAKVII EKIIQIYEMM
LIRHGYMIVG EPWAGKTVSY RMLAEALGEL HAMTNGEEKK VEYKVLNPKS ITMGQLYGQF
DPVTHEWTDG TLATSFRSFS SSTSPDRKWV IFDGPVDAIW IENMNTVLDD NKKLCLTSGE
IMQLTNTMSV MFEVKDLAVA SPATVSRCGM IYMEPSALGW RPIVLSWLNT LPSGIQATDR
DVVLQLFDTM VPACLKFKKG TKEFVPLPVM DSVYCLMNLM FAQMDEFVPA DGASVAASDQ
ATDDPTAKTA LVAYFIFSCT WAMGGNMDVE DRVKFDKFFR VEMAAHTDLF EKSVPDQGLL
FDYFFQRDRK SGSGGSWKLW SDSLGEYTIP ANAKFSQILV PTVDTARYTH LLDLFIMHNM
RTLFVGPTGT GKSVYVANKL LNGVPSDKFI PLFVNFSAQT SANQVQDIVL AKLDKRKKGT
LGPPLGKRAI IFVDDLNMPA REKYGAQPPV ELLRQWMDHG NWYDLKDTSK IELIDLQFIA
AMGPPGGGRN PVTPRFLRHF NTIGVATFDQ VTLKRIFNTI ISWHLKKGFP AEVQELTAGL
IDATHDVYIS SMEMLLPTPA KSHYVFNLRD FSRVVQGLLL ARGEKFSDRM KMVRLWVHEI
YRVFYDRLVD DSDRTTFFSL VKGVCARFFK TSLDAACAHL DANKDGQVTD DDLRSLMFGD
YMQTTAAVRF YDEVASVDAA IDVFKLKLDE YNQLTKSPMN LVIFRFAVEH VSRICRILNQ
PSGHALLVGV GGSGRQSLTR LAASASECLL FQVEISKNYS RKEWSEDLKK VLLKAGVEGK
PSVFLFSDTQ IKQESFLEDI NNMLNSGEVP NLFPPDEKAQ LCDNIRNSVL RNTKVEMSVA
AIYNIFVQRC KENLHVVLAM SPIGDAFRNR LRMFPSLVNC CTIDWFQRWP DDALQVVANK
FLEDVELDDS VRGSVVDMCK TYHSDTISLS TRFFAEVRRH NYVTPTSYLE LIQTFKVLLA
SKRKEIQLLR NRYETGLDQL ASASAQVATM QVELNDLKPK LIVTQKETND LLVVIQRDSV
EVEKKRALVK SDEAIANKKA SEAKAIKDEC EADLSQALPV LESALSALDT LKPQDITLVK
SMKNPPLGVK IAMEAICIML DVKPARVKDQ SGKMVEDYWG PAQKILADSK FLANLKSYDK
DNIPPKIIQK IRKDYVPNPD FDPNVIKNAS AAAEGLCRWV RALDSYDVVA KVVAPKKEAL
AKAEQELATE MGKLNAKRAE LKEVEDKMVA LESQFQEMTR KKEELESQVD LVSKKLIRAE
QLIGGLGGEK QRWSEMAFQL AQTYRNLTGD VLLSSGVIAY LGAFTMPYRM DAIARWNAAC
IDKAIPCSPS FTLATTLGDP IQIRAWTIAG LPNDSFSKDN GIIMAKTRRW PLFIDPQGQA
NRWIKNMEKS NRLAVIKLSD ADYVRTLESA IQFGTPVLLE NVGEEIDSVL EPLLTKQLFK
QSGVMCIRLG DSIIEYSPEF RFYVTTKLRN PHYMPELSTK VTILNFMITP EGLEDQLLGI
VAAKERPELE EEKNKLVLAS AQNKKQLKEI EDKILEILSG EGNILEDETA ITALSSSKVL
SDDIAQKQQP IAFHSSILFF AVADMANIEP MYQYSLTWFL GLYLSSIQDS EKSPDLETRL
ANLTSHFTYL LFCNVCRSLF KKDKLLFSFL LSIGISRGKD EIVADEWAFL LTGGISVGKM
AIENPAHEWL SDKAWAEINT LTQMPVFVGL DEQFVTHLDK WKEIYDSQEP HRAVFPGELQ
EKITPFQRLM LIRAVRPDKQ VPAIQDYVKG KMGQKYIEFP PFDLAASYND SNNVTPLIFI
LSPGADPMGG LLRFADTKGF GGSKCNSISL GQGQGPIAAN MIKTAARQGS WVVLQNCHLA
VSWLPSMEKI VEELGVDSTH REFRLWLTSY PSDKFPVTVL QNGIKMTNEP PAGLRANMIR
SFLGDPISDE VFFKGVKKND HAFKRLLFSL CFFHAVVQER RNFGPLGWNV PYEFNETDLN
ISTRQLHKFL NEYDEIPFKA LVYLAGECNY GGRVTDDRDR RCLMSLLSLF YNPDIVKEGY
RLSPSGLYVV PKTPHHTEIL EHIKAFPLNQ MPEVFGIHEN GDITKDLNET NLMIASILQT
QGRMTGGSAS GSSTDDRMRD IAQDVLGKLP PNFDVPSVQL KYPVNYLESM NTVLIQELVR
FNKLLSIIRD SMQQVVKAVK GLIVMSSELE QLVNSLLVGK VPDMWMGKSY PSLKGLGSYV
ADFIKRLEFF QHWIDHGTPV VFWISGFFFT QSFLTGTLQN YARKYSIPID LLVMHFRMLR
TDTADTAPVD GVFIHGMFLE GGRWDRETDA LADSRPKILF DAMPIVHVLP CPPESDLIEA
SKREARFDAP VYKTSARRGT LSTTGHSTNY VMTIGLPSQV PVRHWINRGC AILLQLDS
//
