ID A0A0L0SIA3_ALLM3 Unreviewed; 4257 AA.
AC A0A0L0SIA3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0008006|Google:ProtNLM};
GN ORFNames=AMAG_07319 {ECO:0000313|EMBL:KNE62065.1};
OS Allomyces macrogynus (strain ATCC 38327) (Allomyces javanicus var.
OS macrogynus).
OC Eukaryota; Fungi; Fungi incertae sedis; Blastocladiomycota;
OC Blastocladiomycetes; Blastocladiales; Blastocladiaceae; Allomyces.
OX NCBI_TaxID=578462 {ECO:0000313|EMBL:KNE62065.1, ECO:0000313|Proteomes:UP000054350};
RN [1] {ECO:0000313|EMBL:KNE62065.1, ECO:0000313|Proteomes:UP000054350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 38327 {ECO:0000313|EMBL:KNE62065.1,
RC ECO:0000313|Proteomes:UP000054350};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Heiman D., Howarth C., Larimer J., Lui A., MacDonald P.J.P.,
RA McCowen C., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "Annotation of Allomyces macrogynus ATCC 38327.";
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 38327 {ECO:0000313|Proteomes:UP000054350};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Borenstein D., Chen Z.,
RA Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B., Mehta T.,
RA Park D., Pearson M., Roberts A., Saif S., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Burger G., Gray M.W.,
RA Holland P.W.H., King N., Lang F.B.F., Roger A.J., Ruiz-Trillo I.,
RA Lander E., Nusbaum C.;
RT "The Genome Sequence of Allomyces macrogynus strain ATCC 38327.";
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG745339; KNE62065.1; -; Genomic_DNA.
DR STRING; 578462.A0A0L0SIA3; -.
DR EnsemblFungi; KNE62065; KNE62065; AMAG_07319.
DR VEuPathDB; FungiDB:AMAG_07319; -.
DR eggNOG; KOG3595; Eukaryota.
DR OMA; HNVAKMV; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000054350; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46961:SF5; DYNEIN HEAVY CHAIN 6; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054350}.
FT DOMAIN 913..1314
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1440..1766
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1926..2039
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2252..2331
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2396..2656
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2670..3014
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3043..3264
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3529..3642
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3674..3813
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3819..4100
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 77..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 664..698
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2899..2947
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4257 AA; 477830 MW; 9366A7D81ADA65B4 CRC64;
MQLNGALATK RKPQPLLGPL KSPAPLAGGA GGAIGPGAYT NIRASHAVLP AVPAVGPFPV
RETELLSASS SLDLDGDAPG ANGMLAQAEG RAGGMGRAAQ WKAPAVHASP HGSSRALFAG
VMGADATSSA LEPKVIRPYK PRPGETPRRI EIERKKRLFA SQDIGAMLDD HGISPQDLIT
PIPLHVFDNT DYEARHAYEW LNMDKSPIQL YKKGGWSTET EAGTTVIPAA IPVPGNALIS
GAWRPVVMTG YDAAAALWRV QYHVESHGGA LAHEPVEAFV PRIFLHFLAE DTHVFVRRIE
SALQLHKETH SLLKLSLFVE CMPALQSSDL PAPTLDKIVE RSVVRQPHLG KLAAKAVGDA
LRAECKKAYH EAMKRLIFDA ELHGKHADKY AYLHLTLPPA PPPRPARVPA DPAPLFEQRR
REFAFQSFLT KLQVIATWRT VRLVCHQLLD MNMYLVNAAK VMRIEEFEQA QVQNVLGVKT
FIRDEWIKAV KSSIQAGLKD VTQGWYNIQV TKFEVYTMSK LKSFMTAIKF LMEDSMRTLT
LTSLESLVAL LGHPNPKKPL LHLELMYRDG AVVYDCPWAQ VEGTILGLVD KALAVLEGVP
DVEPMVLSHL FWATKPLLSC VGKNEPVVTA FRDQLVAHLK AMHATLTAHL ATFDPHLKLL
KVDVAQFIAD YEAANKSVEE MERDMARYHR EWEELDKSLA PAQLSIFQVH CEILRKDLKK
DLAKAILELL ARRTAKSALA ISATFAKMQA RCKEKPLKAE ELSELREYLK AIPDQVAELR
GKIDAMVDDF NVLDKYRYEL ANDDFKAKWA AIGWPGQIDK LLKQAEEALM TDEQNFIRNL
QQDQELFKEK LHHLAGVISD FARHSDLIKL AEIVAEVQRV TLELKEAQAL SQLYTSRERL
FALPVTNYDE LTFLVKDFEP YRTLWVSASD WMKWKGAWLL GSFLDLNAEE VERNLMGAWR
AMFKTVKTFK NSPGCLAVAT QLKDEMEEFK PSLPLIQAFR NPGMRDRHWE RLSNDLGVDV
CPKPGTTLSD ILKMRLMDRL EMISKVAEEA GKEYSIEAAL DKMEGEWRNV QLEVLPYRET
GTYIMKLADE VTRLLDDHIV MTQSMNFSPF KKPFAERITM WDSKLRVIQE VLEEWAMCQR
QWMYLEPIFG SQDIVRQLPT ESKRFSTVDK SWRKIMQNAF AKPNVVEICA DAKLLDTFRE
CNKLLEMVSK GLSAYLESKR VAFPRFFFLS DDELLQILSQ TRDPTAVQPH LRKAFENMTT
LQFEPDGKIT AMYSADGECV QFDQPFYPTG NVEEWLMRVE NTMKSSLHAV LRQAIIDYPN
RKREEWVLDW PGQLVIAGSQ TYFTKEVTES IRAGKLTEMY AKQLAALDGL VGLVRGELSD
IARLSIGALI VIDVHARDVV RQLMEAKIEN DNDFEWISQL RYYWEDDDLH IRIVNAHFKY
GYEYLGNNGR LVITQLTDRC YLTLTGAMHL GMGGAPAGPA GTGKTETTKD LAKALAKQCV
VFNCSDQLDY LAMAKFFKGL SSAGAWACFD EFNRIDIEVL SVIAQQITTI QKAVAAGMTK
FVFEGVELRL DPTNAIFITM NPGYAGRTEL PDNLKALFRP VAMMIPDYGM IGEISLFSFG
FSDAKKLAQK MVATFKLSSE QLSSQDHYDF GMRAVKTVIS AAGNLKRVYP TAGEDVLLLR
ALCDVNVPKF LAEDVPLFNG IISDLFPGLA QPKADHATLF GSLEKICTKH HLLPEESFLQ
KCLQMFDTIN VRHGMMLVGP TGGGKTSCYR VLKEALPDAG ICQVRVNSLN PKSITMGQLY
GEFDEQTHEW SDGILSCMVR DGAADTSGDR KWYIFDGPVD AVWIESMNTV LDDNKKLCLT
SGEIIKLIPT QTLIFEVDNL AHASPATVSR CGMVYMEPGA LGLAPLVKSW LKRKAFPQQG
ADAVLSLFTK IGFLAIEFTR KNIKEAVATT DGNLVQSALR VLGALLQKHA TEEDPNAGLK
HLDAFFYFSL VWSAGASSDG ASRHKFSTWL QEQVLTLPQD GILHDYRYDA ENQRWVNWMA
DMKGPQRNGM MVATMDTIRH DYLLDLLLHN ECPVLCTGPT GTGKSVAITE KIMKGMAENF
SPIVVNFSAR TSANQSQDLL DSKVEKRRKG VYGPPLGKKL VIFIDDLNMP QMEVTGAQPP
IELLRQWMDY GGWYDRKQVG KFMEIVDIVF VAAMGPPGGG RNPITQRLTR HFNLLSFVEM
DDTSLRHIFK TILGTVTDQR AEWGPDLCGK LVDGSIHVYN TLRQELLPTP SKSHYTYNLR
DLSKVFQGML MAETRSIETA NDFILLWVHE SQRVFSDRLV DATDKGWFTT LLKKTMVSTL
GVPWEEVVHV EPVLYGDYMT PGADPKHYVQ VRDLKKVVKL TEEYLEDYNN QVSKPMKLVM
FLDAIEHVSR ICRILRQPRG NALLLGVGGS GRQSLARLAC HMEEYECFQV EISKNYGQNE
WKEDLKKVLF RAGIDAKQTV FLYCDTQVFQ ESCVEDVNNL LNSGDVPNLY TNDDLDRIYN
AIRPIAQDAG LIPTKENMFS MYLNRVRENL HLVFCMSPIG DAFRNRLRMF PSLVNCCTID
WFSMWPEEAL RSVAANSVAE VSDLGTEQVL EGIVTLCVVM HESVRDKCLE FRQQLGRNNY
ITPTSYLELL GLYKKLLDKK RSEIQALRKR TATGLDKLLN ATKEVQVLQE ELEAMQPMLI
QTSQETEYAM KKIAADKIKA EEIREIVQRE EAEASKKADE TKSIADDAQR DLDEALPALA
AALESLNSLS KNDVIEVRSM QRPPEGVKLV MEAVCIMKGL KPKKVDGDKP GKKVDDYWEV
GKSMLSEPAK FLDSLMTFDK DNIPEAVITK IKPYIDNPDF AVEVISKVSK AATSICAWVR
AMEKYYWVSR SIEPKRARLK EAQDSLEVTL KTVAELRQKL KEAEVNINEM EKKYLESVAK
KEELGRKVAE CNVKLGRAGK LISGLSSERV RWSASVEQFD QQLQNIVGDV LLCAGTIAYL
GPFTTEYRQS LLKEWSLCLG KLGIPHSPST SLMEVLGEPA MVRAWELAGL PKDSLSRENA
LISFNSRRWS LFIDPQGQAN KWIRNMEKDN ALDIIKLSDR DYLRTLENSI RFGKPCLLEN
VEEKLDAALE PVLLRQTFKQ NGNTVIKLGD NVLPYHPDFK LYITTKLPNP HYSPEISAIV
TLLNFTLAAS GLEDQLLAIV VANERPDLEE AKNQLMTSNA QMKKELQEIE DKILYLLSSV
QGSPVDDERL IDTLAASKLT SSEITAKVAQ AEITEKDIDT TRSGYVSVAI RTRILFFCIT
EMSRIDPMYQ YSLGWFMNIF SSALRLSEKS QDLQQRLANI IDYFTFSLYS NVCRSLFERH
KLLFSFLLSV RILLNENRIN IEDFKYLITG SAPASTGGGG GGGGGGGGGG AGSTERALPN
PAKDWLTEMA WTDVQTLSKL DAFNGLAEEF CLSPNEFRRI FDSPTPHKEP LCGEWDTRLD
TFQKLCLYRC LCADRMVAGF QDFVGKTLGD RFIEPQTSDF SAIYKESTPW TPLIFVLSPG
ADPANNLYRF AEDMKFSKKL LSVSLGQGQG PRAEALLREG MEKGLWILLQ NCHLAPSWMP
TLDKLVDAIT PDKVHRDFRL WLTSMPTPKF PVSILQNGVK LTIEPPNGIK ANLLRTYASF
NDDFVEDCTK SSEWKKLLFA LSLFHAIVQE RRKFGPLGWN IPYEFTDGDN RICIRQLKMF
LDEYKEIPFK VLNYTVGHIN YGGRVTDDWD RRLIMSILAD YYTPLALEDN YKFSPTCDVY
YTLPTTNMNG YRAYIKGLPL NEPTDIFCMH GNANITFAQK ETFTLFETLT TLMPRAGGGK
AGTSREEQLI GVCESIVTRV ARPLDLDSIM RKYPTDYKES MSTVLVQEVV RYNRVLKLVH
ASLQDLIKAL KGVVVMSEQL DAMANSMSIN QVPVMWSARA YPSLKPLSSW VTDLVARIDF
LQQWIDHGIP KVFWISGLYF PQAFLTGTLQ NFARKYAIPI DTLQFSFHMR SEQWESITER
PEDGCYIRGL LLEGARWDMV AGVLAESRPK ELYTDMAVMW LLPVQHRKKP SEGIYDCPVY
KTLTRAGTLS TTGHSTNYLT VLLYAGATGI MASQAFNTAI TETKAATTGL LTTASAYIAG
IPTTVNTMAN TIDSAVTSLQ SGVSTLPIDA QVIQPTIARP FGAFQSTLDA LANNVTIATT
STSTIQQLVT TTQAGRSSLS SELTNLQGNV TALNSITIDG SSYSLSNPPK GGNWEKQ
//
