ID A0A0L0SJN5_ALLM3 Unreviewed; 1124 AA.
AC A0A0L0SJN5;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Cytochrome b5 heme-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AMAG_07884 {ECO:0000313|EMBL:KNE62692.1};
OS Allomyces macrogynus (strain ATCC 38327) (Allomyces javanicus var.
OS macrogynus).
OC Eukaryota; Fungi; Fungi incertae sedis; Blastocladiomycota;
OC Blastocladiomycetes; Blastocladiales; Blastocladiaceae; Allomyces.
OX NCBI_TaxID=578462 {ECO:0000313|EMBL:KNE62692.1, ECO:0000313|Proteomes:UP000054350};
RN [1] {ECO:0000313|EMBL:KNE62692.1, ECO:0000313|Proteomes:UP000054350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 38327 {ECO:0000313|EMBL:KNE62692.1,
RC ECO:0000313|Proteomes:UP000054350};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Heiman D., Howarth C., Larimer J., Lui A., MacDonald P.J.P.,
RA McCowen C., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "Annotation of Allomyces macrogynus ATCC 38327.";
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 38327 {ECO:0000313|Proteomes:UP000054350};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Borenstein D., Chen Z.,
RA Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B., Mehta T.,
RA Park D., Pearson M., Roberts A., Saif S., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Burger G., Gray M.W.,
RA Holland P.W.H., King N., Lang F.B.F., Roger A.J., Ruiz-Trillo I.,
RA Lander E., Nusbaum C.;
RT "The Genome Sequence of Allomyces macrogynus strain ATCC 38327.";
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG745340; KNE62692.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0SJN5; -.
DR STRING; 578462.A0A0L0SJN5; -.
DR EnsemblFungi; KNE62692; KNE62692; AMAG_07884.
DR VEuPathDB; FungiDB:AMAG_07884; -.
DR eggNOG; KOG0039; Eukaryota.
DR eggNOG; KOG2408; Eukaryota.
DR OrthoDB; 2901594at2759; -.
DR Proteomes; UP000054350; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0004601; F:peroxidase activity; IEA:InterPro.
DR GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
DR CDD; cd08760; Cyt_b561_FRRS1_like; 1.
DR CDD; cd09631; DOMON_DOH; 1.
DR Gene3D; 1.20.120.1770; -; 1.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR Gene3D; 1.10.640.10; Haem peroxidase domain superfamily, animal type; 2.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR006593; Cyt_b561/ferric_Rdtase_TM.
DR InterPro; IPR045266; DOH_DOMON.
DR InterPro; IPR005018; DOMON_domain.
DR InterPro; IPR019791; Haem_peroxidase_animal.
DR InterPro; IPR010255; Haem_peroxidase_sf.
DR InterPro; IPR037120; Haem_peroxidase_sf_animal.
DR PANTHER; PTHR11475:SF4; LD42267P; 1.
DR PANTHER; PTHR11475; OXIDASE/PEROXIDASE; 1.
DR Pfam; PF03098; An_peroxidase; 2.
DR Pfam; PF00173; Cyt-b5; 1.
DR Pfam; PF03351; DOMON; 1.
DR SMART; SM00665; B561; 1.
DR SMART; SM01117; Cyt-b5; 1.
DR SMART; SM00664; DoH; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR SUPFAM; SSF48113; Heme-dependent peroxidases; 1.
DR PROSITE; PS50255; CYTOCHROME_B5_2; 1.
DR PROSITE; PS50836; DOMON; 1.
DR PROSITE; PS50292; PEROXIDASE_3; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054350};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 777..801
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 813..832
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 844..863
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 875..899
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 911..933
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 611..729
FT /note="DOMON"
FT /evidence="ECO:0000259|PROSITE:PS50836"
FT DOMAIN 979..1034
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
FT REGION 1031..1124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1052..1066
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1091..1124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1124 AA; 119775 MW; F306561A9B98F1F3 CRC64;
MHGAPTRAFR RAEDRPRVCI NRVHARASAG APPRVPSPFR LCRPPRRRRA RRLAAALAEQ
DLAGALTPCA SYAAAAARRA ASPRWLSQPR TPPWAAVSTE FRTMHSRSSV STNSFLPSLM
SARYLLSLPS RLAHRARRGP AAPSSPPPAL TAATQSAILL LFALACLASF GSQPLVPVAR
AQSVTAAIPW NGWGNNLVRP EWGATNASAA TLSRTLIPSV FADNVSVPAP SAAGSARAMV
TALFSNASVA AAVANVPRTA AWSAFASHLT ELVYLDLVRL APNVSDPWPM PVPACDPEWD
EMCLGGVTLP YFRVQATLTG PHGERAALNS ATPYLDLEFL YGQSLAAAAP LRSFTDGQLL
LPNGYLQNTT TTTAQLLDDV LVPAGTTLFL AGDLRINKNP ALAAMVTLLA REHNRRAVQL
KAAGQFVSDD DLFANARRWT IGVWQHMVHD DVLHRSMDLG VPKYNAVRTA LGLTAATSFA
SISSTPAMQA ALAAMYPSVS SVDACVGAWA EDPKPYARVG TTFATAWQRQ LLAVRNGDRF
WYQNTLANAD YLAVKRRVWA NLVSEFTGVA RFPKSVVEVV PDASSAFVNV TTSSNSTTTE
GGGSPVVKLT DGVWLNWTLS TTSITFEATV TKSGWFAFAI GSGMPNFQDV ALVTWVNGVP
TIADAYTNGY APAVDTTQPG GTSLLVLNYS KDALGRNHYV WTRPLMSTDP WDLNITNPAG
PTSCAFALGT SPGVSYHGAL RGVVALTFNT TTTNTGGVTL PPPTTVVSTN WPLGVQLLHG
AFMVSAFYGA IPLGVITARY LVNKKWLNQH IKFSMFVLSQ VSVSIATAII GANIDLLALP
HGMIGVGTMV LLMVATVYGA LIAKELNASL RTYRMLRWSH IVVAMSAWGL GMYNCFLGLG
IVVERNPDLE WLHWLLVFLT GFVAVIMASF EVWRIKNGKV MLKGLVKLNA AHAGAGHGVA
AGVAGAMFAE ADDDHDKTMP EFTWDDINAK IADGSLWLVI EGVVYDITYF VNSHPGDDIL
RYVGTDASAA FEGMPAPGPP PPAAAAGGTR QTRPEHARDR RSSGTSTPRR HGAFPLPSAA
APAVPRPSTT ALGGCTCTRV ARGTSSPPWP SASSRKARSG RTTC
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