ID A0A0L0SKD2_ALLM3 Unreviewed; 1321 AA.
AC A0A0L0SKD2;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Cyclic nucleotide-binding domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AMAG_18930 {ECO:0000313|EMBL:KNE62879.1};
OS Allomyces macrogynus (strain ATCC 38327) (Allomyces javanicus var.
OS macrogynus).
OC Eukaryota; Fungi; Fungi incertae sedis; Blastocladiomycota;
OC Blastocladiomycetes; Blastocladiales; Blastocladiaceae; Allomyces.
OX NCBI_TaxID=578462 {ECO:0000313|EMBL:KNE62879.1, ECO:0000313|Proteomes:UP000054350};
RN [1] {ECO:0000313|EMBL:KNE62879.1, ECO:0000313|Proteomes:UP000054350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 38327 {ECO:0000313|EMBL:KNE62879.1,
RC ECO:0000313|Proteomes:UP000054350};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Heiman D., Howarth C., Larimer J., Lui A., MacDonald P.J.P.,
RA McCowen C., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "Annotation of Allomyces macrogynus ATCC 38327.";
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 38327 {ECO:0000313|Proteomes:UP000054350};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Borenstein D., Chen Z.,
RA Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B., Mehta T.,
RA Park D., Pearson M., Roberts A., Saif S., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Burger G., Gray M.W.,
RA Holland P.W.H., King N., Lang F.B.F., Roger A.J., Ruiz-Trillo I.,
RA Lander E., Nusbaum C.;
RT "The Genome Sequence of Allomyces macrogynus strain ATCC 38327.";
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; GG745341; KNE62879.1; -; Genomic_DNA.
DR STRING; 578462.A0A0L0SKD2; -.
DR EnsemblFungi; KNE62879; KNE62879; AMAG_18930.
DR VEuPathDB; FungiDB:AMAG_18930; -.
DR eggNOG; KOG0500; Eukaryota.
DR eggNOG; KOG4628; Eukaryota.
DR OrthoDB; 1333420at2759; -.
DR Proteomes; UP000054350; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd16454; RING-H2_PA-TM-RING; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR PANTHER; PTHR45638:SF19; CYCLIC NUCLEOTIDE-GATED POTASSIUM CHANNEL; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Reference proteome {ECO:0000313|Proteomes:UP000054350};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00175};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00175}.
FT TRANSMEM 99..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..253
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..297
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 309..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 911..940
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 412..512
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 1197..1243
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 537..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 631..651
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 670..762
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 978..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1134..1161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 682..702
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 983..998
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1321 AA; 142250 MW; F480AB02131547AE CRC64;
MNYDDDEPPT PVIRTSKLQK MGGGGAGAGP DSPTDGSPGG GLGGPGGGGA AGTLMHKDGG
MPKRKWYQIT IPPPRELWQN LWRFYLIPGE PFLTWWDRFM VLVAVSNGTS IPFMAAFRYL
DSTSIVGQYV IDVLYLIDIF LKFHVSYLDR GFYVIFPKEM ALHYMRSWEF SFDLFTNLPF
DLIALSWLHL PLNQVLYYLS IVRLHKLFRT FKLVWWFHKE EKRLNAQAVF QMYKFTIYIT
LITHWCTCIW YVLACPDQCI TPSWATDPAQ NPKFADRLSM YVYALYWTVM TMTTTGYGDV
HATNDGERIW SIICMITGVF LYGYVSGTIA SSLSNLDSRR VSYRQKVEAI KQYMLDQNMD
KTMQKRVTGW YEYTWERNKG IDVINVFNDL PSNFRAEVAL SLNEDIIEKV SIFKDTSLGF
RRMLSIAMRI NFFTAETYIV HRGEIGKEMF FVVQGRVDVL NDDETESVGS MVEGSYFGEF
MLILGHVCEA SALAVCNCDV YVLSKDDYDK AVANYPEDGA KVLEATRVAH QQVLQRRVSQ
TGHGAPGAAP GATGGAAGRR ASHPHMDHGG VDDPPPPPPA TSIGTVVVGA QGTARVVRGS
AMSIRGATPA SGAVTPQPGN WHVGMSAASM VSASSGAPPP VMAPRSGAGR RPSIGYFVMD
EADHRRIEQI KQDKRRKSLA GSRVSIASSA GTRQSNDMAE MPNAPGTQGM PRKPSGSAAR
VVGSPSTPGG MNRAFSGSSA TSDEDEMRRG SGGGGSGGTH PVAHASLAAF SAPGASSPID
ARDRGSAWAP APAGQGSMLG GSRAGSAVLS LETTMPAPPR SAAYTAMPPL TTTTTTARTA
TAGTASSARA AHFLAPRAPR ADDNGALRIT DGPGSFIEPH GSVQVAKTGV AQNDNNASTS
SDTSAVAVGS VVIYVLGALV AFVVLVYVLY WLLAFPLPWI RRWYQRHKSR RQLCRALSHS
DKFPVFRFDP LAVRPRTTAR SGCGGDTAPT STAAGTATRA NSPCASLTAT DAFVPVAVEL
SPVIPTRRID DDLEPVVHGA ARDDETGAFV AVPLDGDGST PATAPAADDD QTPLALAGAL
AMSPPLPPVP RAVAFAPMCT SPVDSTDPEI PHHAVLVEYG AASDATSSCA GSSSRISLTG
SSKSPTCSSS SICSGSRPVS PQRDASIVAV PLDQDASRAA TDAGEQEGFV STTSLTCSIC
LEDYALNDAI RELPCHHDFH AKCVQPWLER ALTDRVIACP ICRASWPLSS LTQDLHRTPS
ARARLRRWRH RTLSGLGTST TPAAAPTVTP PRAHHRLRRA YRKPRADRAR CPVRRRATCL
G
//
