ID A0A0L0SKL9_ALLM3 Unreviewed; 4079 AA.
AC A0A0L0SKL9;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Dynein heavy chain, cytoplasmic {ECO:0008006|Google:ProtNLM};
GN ORFNames=AMAG_08223 {ECO:0000313|EMBL:KNE63057.1};
OS Allomyces macrogynus (strain ATCC 38327) (Allomyces javanicus var.
OS macrogynus).
OC Eukaryota; Fungi; Fungi incertae sedis; Blastocladiomycota;
OC Blastocladiomycetes; Blastocladiales; Blastocladiaceae; Allomyces.
OX NCBI_TaxID=578462 {ECO:0000313|EMBL:KNE63057.1, ECO:0000313|Proteomes:UP000054350};
RN [1] {ECO:0000313|EMBL:KNE63057.1, ECO:0000313|Proteomes:UP000054350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 38327 {ECO:0000313|EMBL:KNE63057.1,
RC ECO:0000313|Proteomes:UP000054350};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Heiman D., Howarth C., Larimer J., Lui A., MacDonald P.J.P.,
RA McCowen C., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "Annotation of Allomyces macrogynus ATCC 38327.";
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 38327 {ECO:0000313|Proteomes:UP000054350};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Borenstein D., Chen Z.,
RA Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B., Mehta T.,
RA Park D., Pearson M., Roberts A., Saif S., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Burger G., Gray M.W.,
RA Holland P.W.H., King N., Lang F.B.F., Roger A.J., Ruiz-Trillo I.,
RA Lander E., Nusbaum C.;
RT "The Genome Sequence of Allomyces macrogynus strain ATCC 38327.";
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; GG745341; KNE63057.1; -; Genomic_DNA.
DR STRING; 578462.A0A0L0SKL9; -.
DR EnsemblFungi; KNE63057; KNE63057; AMAG_08223.
DR VEuPathDB; FungiDB:AMAG_08223; -.
DR eggNOG; KOG3595; Eukaryota.
DR OMA; HAIVCER; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000054350; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46961:SF5; DYNEIN HEAVY CHAIN 6; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054350}.
FT DOMAIN 913..1314
FT /note="Dynein heavy chain linker"
FT /evidence="ECO:0000259|Pfam:PF08393"
FT DOMAIN 1440..1766
FT /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT motor region"
FT /evidence="ECO:0000259|Pfam:PF12774"
FT DOMAIN 1926..2039
FT /note="Dynein heavy chain AAA 5 extension"
FT /evidence="ECO:0000259|Pfam:PF17852"
FT DOMAIN 2252..2331
FT /note="Dynein heavy chain 3 AAA+ lid"
FT /evidence="ECO:0000259|Pfam:PF17857"
FT DOMAIN 2396..2638
FT /note="Dynein heavy chain AAA module D4"
FT /evidence="ECO:0000259|Pfam:PF12780"
FT DOMAIN 2652..2996
FT /note="Dynein heavy chain coiled coil stalk"
FT /evidence="ECO:0000259|Pfam:PF12777"
FT DOMAIN 3025..3246
FT /note="Dynein heavy chain ATP-binding dynein motor region"
FT /evidence="ECO:0000259|Pfam:PF12781"
FT DOMAIN 3506..3619
FT /note="Dynein heavy chain region D6 P-loop"
FT /evidence="ECO:0000259|Pfam:PF03028"
FT DOMAIN 3651..3790
FT /note="Dynein heavy chain AAA lid"
FT /evidence="ECO:0000259|Pfam:PF18198"
FT DOMAIN 3796..4073
FT /note="Dynein heavy chain C-terminal"
FT /evidence="ECO:0000259|Pfam:PF18199"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 664..698
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2881..2929
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4079 AA; 459800 MW; 049344CD497F40FE CRC64;
MHINGALATK RKPHPLLGPL KKPALPAGGA GGAIGPSAYT TIRASHAVLP AVPIVGPFPV
RETELLSASS SLDLDGDAPG ANGLLAQAER RAGGMARAAQ WKAPAVHASP HGSSRALFAG
APGADTASSA LEPKVIRPYV PRPGETPRRI EIERKKRLFA SQDIGAMLDD HGISPQDLIT
PIPLHVFDNT DYEARHACEW LNMDKSPIQL YKKGGWSTEA EAGTTVIPAA IPVPGNALIS
GAWRPVVMTG YDAAAALWRV QYHVNSHGDE LAHEPVEAFL PRLFLHFLAE DTHVFVRRIA
SALQLHKETM SLLNLSLFVE CMPALQSSDL PAPTLDKIVE RSVVRQPHLG KLAAKAVGDA
LRAECKKAYH EAMKRLIFDA ELHGKHADKY TYLHLTLPPA PPPRPARVPA DPAPLFEQRR
REFAFQSFLT KLQVIATWRT VRLVCHQLLD MNMYLVNAAK VMRIEEFEQV QVQNVLGVKT
FIRDEWIKAV KSSIQAGLKD VTQGWYNIQV TKFEVYTMSK LKSFMTAVKF LMEDSMRTLT
LMSLESLVAL LGHPNPKKPL LHLELMYRDG AVVYDCPWAQ VEGTILGLVD KALAVLEGVP
DVEPMVLSHL FWATKPLLSC VGKSEPVVTA FRDQLVAHLK AMHATLTAHL ATFDPHLKLL
KVDVAQFIAE YEAANKSVEE MERDMAQYHR EWEELDKSLA PAQLGIFQVH CEILRKDLKK
DLAKAILELL ARRTAKSALA ISAAFAKIQA RCKEKPLKAE ELSELREYLK AIPDQVAELR
DKIDAMVDDF NVLDKYRYEL ANDDFKAKWA AIGWPDQIDK LLKHAEDALM TDEQNFIRNL
QQDQDLFKEK LHHLAGVISD FARHSDLNKL AEIVAEVQRV TLELNEAQAL SQLYNSRERL
FALPVTNYDE LTFMVKDFEP YRTLWVSASD WMKWKGAWLH GSFLDLNAED VERNLMGAWR
AMFKTVKTFK NSPGCLAVAT QLKDEMEEFK PSLPLIQAFR NPGMRDRHWE RLSNDLGVDV
CPKPGTTLSD ILKMRLMDRL EMISKVAEEA GKEYSIEAAL DKMEGEWRNV QLEVLAYRET
GTYIMKLADE VTRLLDDHIV MTQSMNFSPF KKPFAERITM WDGKLRVMQE VLEEWAMCQR
QWMYLEPIFG SQDIVRQLPT ESKRFSTVDK SWRKIMQNAF AKPNVVEICA DAKLLDTFRE
CNKLLEMVSK GLSAYLESKR VAFPRFFFLS DDELLQILSQ TRDPTAVQPH LRKAFENMTT
LQFEPDGKIT AMYSADGECV QFDQPFYPTG NVEEWLMRVE NTMKSSLHAV MRQAITDYPN
RKREEWVLDW PGQLVIAGSQ TYFTKEVTES IRAGKLTDMY AKQLAALDGL VGLVRGELSD
IARLSIGALI VIDVHARDVV RQLMEAKIEN DNDFEWISQL RYYWEDDDLH IRIVNAHFKY
GYEYLGNNGR LVITQLTDRC YLTLTGAMHL GMGGAPAGPA GTGKTETTKD LAKALAKQCV
VFNCSDQLDY LAMAKFFKGL SSAGAWACFD EFNRIDIEVL SVIAQQITTI QKAVAAGMTK
FVFEGVELRL DSTNAIFITM NPGYAGRTEL PDNLKALFRP VAMMIPDYGM IGEISLFSFG
FSDAKKLAQK MVATFKLSSE QLSSQDHYDF GMRAVKTVIS AAGNLKRAYP TAGEDVLLLR
ALCDVNVPKF LAEDVPLFNG IISDLFPGLA QPKADHATLF GSLEKICAKH HLLPEESFLQ
KCLQMFDTIN VRHGMMLVGP TGGGKTSCYR VLKEALPDAG VCQVRVNSLN PKSITMGQLY
GEFDEQTHEW SDGILSCMVR DGAADTSGDR KWYVFDGPVD AVWIESMNTV LDDNKKLCLT
SGEIIKLIPT QTLIFEVDNL AHASPATVSR CGMVYMEPGA LGLAPLVKSW LKRKAFPQQG
ADAVLALFTK IGFSAIEFTR KNIKEAVATT DGNLVQSALR VLGALLQKHA TEEDPSAGLK
HLDAYFYFSL VWSAGASSDG ASRHKFSTWL QEQVLTLPQD GILHDYRYDA ENQRWVNWMA
DMKGPQRNGM MVATMDTIRH DYLLDLLLHN ECPVLCTGPT GTGKSVAITE KIMKGMAENF
SPIVVNFSAR TSANQSQDLL DSKVEKRRKG VYGPPLGKKL VIFIDDLNMP QMEVTGAQPP
IELLRQWMDY GGWYDRKQVG KFMEIVDIVF LAAMGPPGGG RNPITQRLTR HFNLLSFVEM
DDTSLRHIFK TILGTVTDQR AEWGPDLCGK LVDGSIHVYN TLRQELLPTP SKSHYTYNLR
DLSKVFQGML MAETRSIETA NDFILLWVHE SQRVFSDRLV DAADKGWFTT LLKKTMVSKL
GVPWEEVVHV EPVLYGDYMT PGADPKHYVQ VKDLKKVVKL TEEYLEDYNN QVSKPMKLVM
FLDAIEHVSR ICRILRQPKG NALLLEYECF QIEISKNYGQ NEWKEDLKKV LFRAGIDAKQ
TVFLYCDTQV FQESCVEDVN NLLNSGDVPN LYTNDDLDRI YNAIRPIAQD AGLIPTKENM
FSMYINRVRE NLHLVFCMSP IGDAFRNRLR MFPSLVNCCT IDWFSMWPEE ALRSVAANSV
AEVSDLGTEQ VLEGIVTLCV VMHESVRDKC LEFRQQLGRN NYITPTSYLE LLGLYKKLLD
KKRSEIQALR KRTATGLDKL LNATKEVQVL QEELEAMQPM LIQTSQETEY AMKKIAADKI
KAEEIREIVQ REEAEASKKA DETKSIADDA QRDLDEALPA LAAALESLNS LSKNDVIEVR
SMQRPPEGVK LVMEAVCIMK GLKPKKVDGD KPGKKVDDYW EVGKSMLSEP AKFLDSLMTF
DKDNISEAVI TKIKPYIENP DFAVEVISKV SKAATSICAW VRAMEKYYWV SRSIEPKRAR
LKEAQDSLEV TLKTVAELRQ KLKEAEVNIN EMEKKYLESV AKKEELGRKV AECNVKLGRA
GKLISGLSSE RVRWSASVEQ FDHQLQSIVG DVLLCAGTIA YLGPFTTEYR QSLLKEWSLC
LGKLGIPHSP STSLMEVLGE PALVRAWELA GLPKDSLSRE NALISFNSRR WSLFIDPQGQ
ANKWIRNMEK DNALDIIKLS DRDYLRTLEN SIRFGKPCLL ENVEEKLDAA LEPVLLRQTF
KQNGNTVIKL GDNVLPYHPD FKLYITTKLP NPHYSPEISA IVTLLNFTLA ASGLEDQLLA
IVVANERPDL EEAKNQLMTS NAQMKKELQE IEDKILYLLS SVQGSPVDDE RLIDTLAASK
LTSSEITAKV AQAEITEKDI DTTRSGYVPV AIRTRILFFC ITEMSRIDPM YQYSLGWFMN
IFSSALRLSE KSQDLQQRLA NIIDYFTFSL YSNVCRSLFE RHKLLFSFLL SVRILLDENR
INIDDFKYLI TGSAPSSTGG GGGGGGGAGS MERALPNPAK DWLTEMAWTD VQTLSKLDAF
NGLAEEFCLS PNEFRRIFDS PTPHKEPLCG EWDTRLDTFQ KLCLYRCLCA DRMVAGIQAF
VGKTLGDRFI EPQTSDFSAI YKESTPWTPL IFVLSPGADP ANNLYRFAED MKFSKKLLSV
SLGQGQGPRA EALLREGMEK GLWILLQNCH LAPSWMPTLD KLVDAITPDK VHRDFRLWLT
SMPTPKFPVS ILQNGVKLTI EPPNGIKANL LRTYASFSDD FVEDCTKSSE WKKLLFALSL
FHAIVQERRK FGPLGWNIPY EFTDGDNRIC VRQLKMFLDE YKEIPFKVLN YTVGHINYGG
RVTDDWDRRL IMSILADYYT PLALEDNYKF SPTCDVYYTL PATNLNGYRA YIKGLPLNEP
TDIFCMHGNA NITFAQKETF TLFETLTTLM PRAGGGKAGT SREEQLIGVC ESIVTRVARP
LDLESILRKY PTDYKESMST VLVQEVVRYN RVLKLVHTSL QDLIKALKGV VVMSEQLDAM
ANSMSINQVP VLWSARAYPS LKPLSSWVTD LVARIDFLQQ WIDHGIPKVF WISGLYFPQA
FLTGTLQNYA RKYAIPIDTL QFSFHMRSER WESITERPDD GCYIRGLLLE GARWDMVAGV
LAESRPKELY TDMAVMWLLP VQHRKKPSEG IYDCPVYKTL TRAGTLSTTG HSDQLWAHN
//
