ID A0A0L0SPF1_ALLM3 Unreviewed; 815 AA.
AC A0A0L0SPF1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=ELMO domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AMAG_09419 {ECO:0000313|EMBL:KNE64396.1};
OS Allomyces macrogynus (strain ATCC 38327) (Allomyces javanicus var.
OS macrogynus).
OC Eukaryota; Fungi; Fungi incertae sedis; Blastocladiomycota;
OC Blastocladiomycetes; Blastocladiales; Blastocladiaceae; Allomyces.
OX NCBI_TaxID=578462 {ECO:0000313|EMBL:KNE64396.1, ECO:0000313|Proteomes:UP000054350};
RN [1] {ECO:0000313|EMBL:KNE64396.1, ECO:0000313|Proteomes:UP000054350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 38327 {ECO:0000313|EMBL:KNE64396.1,
RC ECO:0000313|Proteomes:UP000054350};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Heiman D., Howarth C., Larimer J., Lui A., MacDonald P.J.P.,
RA McCowen C., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "Annotation of Allomyces macrogynus ATCC 38327.";
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 38327 {ECO:0000313|Proteomes:UP000054350};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Borenstein D., Chen Z.,
RA Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B., Mehta T.,
RA Park D., Pearson M., Roberts A., Saif S., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Burger G., Gray M.W.,
RA Holland P.W.H., King N., Lang F.B.F., Roger A.J., Ruiz-Trillo I.,
RA Lander E., Nusbaum C.;
RT "The Genome Sequence of Allomyces macrogynus strain ATCC 38327.";
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in cytoskeletal rearrangements required for
CC phagocytosis of apoptotic cells and cell motility. Acts in association
CC with DOCK1 and CRK. Was initially proposed to be required in complex
CC with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine
CC nucleotide exchange factor (GEF) activity of DOCK1.
CC {ECO:0000256|ARBA:ARBA00024863}.
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DR EMBL; GG745344; KNE64396.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0SPF1; -.
DR STRING; 578462.A0A0L0SPF1; -.
DR EnsemblFungi; KNE64396; KNE64396; AMAG_09419.
DR VEuPathDB; FungiDB:AMAG_09419; -.
DR eggNOG; KOG2999; Eukaryota.
DR OMA; WESHARP; -.
DR OrthoDB; 1473500at2759; -.
DR Proteomes; UP000054350; Unassembled WGS sequence.
DR GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024574; ELMO_ARM.
DR InterPro; IPR006816; ELMO_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR Pfam; PF11841; ELMO_ARM; 1.
DR Pfam; PF04727; ELMO_CED12; 1.
DR Pfam; PF16457; PH_12; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Phagocytosis {ECO:0000256|ARBA:ARBA00022907};
KW Reference proteome {ECO:0000313|Proteomes:UP000054350};
KW SH3-binding {ECO:0000256|ARBA:ARBA00023036}.
FT DOMAIN 120..283
FT /note="ELMO armadillo-like helical"
FT /evidence="ECO:0000259|Pfam:PF11841"
FT DOMAIN 387..476
FT /note="ELMO"
FT /evidence="ECO:0000259|Pfam:PF04727"
FT DOMAIN 553..674
FT /note="PH"
FT /evidence="ECO:0000259|Pfam:PF16457"
SQ SEQUENCE 815 AA; 88579 MW; AD9B93CF95E6BD44 CRC64;
MPKNVQVTVA WEKGTAPATI DVSQPMFLVI QQIVAAIPAF PLGGSGSGAS PGDYCLRTLE
TDELISPENL LRNVKTGETI KIVPAPSLEA PEFRRRLASL DSMVQKRTLF AMQNRVKEEE
FALAFVSAGG VEALKKLVLT SDGNSLAYAL SALSNFMEEH SSLASQQSGL ISSELISRLM
HLVVTETLVN ICRPATALLI RILQLTFTAA EADAARRKAM SATASADALA ALTDNEVAAS
MELVHQVMVT SGKPLLAALI QRLSASEYVL QLHSLALINA VFKFALAGGV TPATTGSWAN
LTAVRPPLLV DMEKLNLRPV VARMMQLSSN EEKNKELVEF QTLTMQHLYR QKSLRLDSLD
AVFDDECGIP DPQNVLQLLG CDAEVPADMA RVGVLGADAL CRFIAKYRSD FNEWAALPVE
TRPSLTKISS EITEYLSDFW ELSTGFSTST TLQPHILLFD QIHHLFIRLF RRLWEDTLDL
NASLGMIRTE LRHVLRNHAL ATMDALEKIV MGTPVSVIRD RHLKELEDED EIMAHPIVRK
LRDVVYKESF EFVKQQRLAC LCAGAWFHLP PNASSAPPIN LGSSTNHGSR KLAKSIVRFC
RLSGTKKTLY YADFPEVLDK KPSLEQLTQR VDLANVADIV TGSTASAIHS SVPTMGGGGS
SGMTSSSTSM SLATAAAVAA AAAAAANNFS GRRGVSPTPS SSSTTTTAMD LRSMHCFSLM
QAGANDADLV SIMDLVCMTP TQYSEWTDGF NLLLNKGITN KDTAEFVQAL TEIQLRIRLL
DITADRIPLY QPAEVPPLPP DVSFFYEDVA GIGGP
//
