ID A0A0L0SRU6_ALLM3 Unreviewed; 831 AA.
AC A0A0L0SRU6;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Ras-GEF domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=AMAG_10926 {ECO:0000313|EMBL:KNE65283.1};
OS Allomyces macrogynus (strain ATCC 38327) (Allomyces javanicus var.
OS macrogynus).
OC Eukaryota; Fungi; Fungi incertae sedis; Blastocladiomycota;
OC Blastocladiomycetes; Blastocladiales; Blastocladiaceae; Allomyces.
OX NCBI_TaxID=578462 {ECO:0000313|EMBL:KNE65283.1, ECO:0000313|Proteomes:UP000054350};
RN [1] {ECO:0000313|EMBL:KNE65283.1, ECO:0000313|Proteomes:UP000054350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 38327 {ECO:0000313|EMBL:KNE65283.1,
RC ECO:0000313|Proteomes:UP000054350};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S.,
RA Hansen M., Heiman D., Howarth C., Larimer J., Lui A., MacDonald P.J.P.,
RA McCowen C., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA Roberts A., Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J.,
RA Nusbaum C., Birren B.;
RT "Annotation of Allomyces macrogynus ATCC 38327.";
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054350}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 38327 {ECO:0000313|Proteomes:UP000054350};
RG The Broad Institute Genome Sequencing Platform;
RA Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA Borodovsky M., Guigo R., Alvarado L., Berlin A., Borenstein D., Chen Z.,
RA Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B., Mehta T.,
RA Park D., Pearson M., Roberts A., Saif S., Shenoy N., Sisk P., Stolte C.,
RA Sykes S., Walk T., White J., Yandava C., Burger G., Gray M.W.,
RA Holland P.W.H., King N., Lang F.B.F., Roger A.J., Ruiz-Trillo I.,
RA Lander E., Nusbaum C.;
RT "The Genome Sequence of Allomyces macrogynus strain ATCC 38327.";
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG745347; KNE65283.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0SRU6; -.
DR EnsemblFungi; KNE65283; KNE65283; AMAG_10926.
DR VEuPathDB; FungiDB:AMAG_10926; -.
DR OrthoDB; 68574at2759; -.
DR Proteomes; UP000054350; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF373; PROTEIN SON OF SEVENLESS; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000054350};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..831
FT /note="Ras-GEF domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005548199"
FT DOMAIN 397..510
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 600..831
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 236..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 324..351
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 242..259
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 831 AA; 92297 MW; 8CBFF5A126753243 CRC64;
MGHIACAALL VACGASPTAA NYRGQTPVNL APESAEWASL FDGVPGRFPS NSRRRTGDAA
TTTTTTAPTA AAFRAALPND VDQLRDIIVH LVAGQSRFQA HCHATIAQLV EEKWTLQQTV
EHHRELLGDS SDLTQLNAMQ ELQFYRERND YLMQLIAKQR HQLHTLQRDL ALKESTFQTQ
LAQLTEQHRT ELREVARTSQ QTIHDMHRQM SMRSVSVDTA VVLGTKSVAE MLDEHAAAAA
GTSTSRPASR STSPWSPDRP SSRAAAAAAA AMAGSSSSAT AAVTAPPRTL RRAQGAVVSA
TMSDKETMVT PTTPDAAFDL ESTRLELVDK LRSAEARNSI LERELADMRQ SLVGLHEHVL
HEVMQEASRG QADMDARDES QGLILFANGG AAEADGGQRQ IRAAVPEKLV ERLIVGHPID
YQLRNTFLLT YREFMTAEDV LAAIQALYRP RKSKIVSRIY NVLSDWMTKY WCDFQGEFLQ
RVMSFLRDHI VPEDQPEILP QIECLVKSKL NSEFSGLITT TTTALGDAVL RTHPAPPPPV
LPKYLRDPLP VGSIGSAAGL GSNPSSSATL AAVGTLSKST AWLRGGSRKE GKGIRFLDLS
MVEVARQLTL VESELFRAMS PLELIGINWM RKNKEETATT VLAMTRWFNH VMQWVRSEVL
MTRETKTRAV VFERFILLAD ELLKLNNFNG VSEIMAALES SAVWRLERTK SLIPTKSKRM
LQDLVANCSP DINYKSLRAL MRDAQPPAVP FPAILERDLY YLDRSLARSI DGKLVNFQRY
QVMADLIQKF QYLQSEGYNL TPVPEIQAYV RDYVPLSDDD AYERSLTCEP R
//
