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Database: UniProt
Entry: A0A0L0SYX5_ALLM3
LinkDB: A0A0L0SYX5_ALLM3
Original site: A0A0L0SYX5_ALLM3 
ID   A0A0L0SYX5_ALLM3        Unreviewed;       245 AA.
AC   A0A0L0SYX5;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   RecName: Full=Eukaryotic translation initiation factor 6 {ECO:0000256|HAMAP-Rule:MF_03132};
DE            Short=eIF-6 {ECO:0000256|HAMAP-Rule:MF_03132};
GN   Name=TIF6 {ECO:0000256|HAMAP-Rule:MF_03132};
GN   ORFNames=AMAG_12487 {ECO:0000313|EMBL:KNE67763.1}, AMAG_14456
GN   {ECO:0000313|EMBL:KNE70310.1};
OS   Allomyces macrogynus (strain ATCC 38327) (Allomyces javanicus var.
OS   macrogynus).
OC   Eukaryota; Fungi; Fungi incertae sedis; Blastocladiomycota;
OC   Blastocladiomycota incertae sedis; Blastocladiomycetes; Blastocladiales;
OC   Blastocladiaceae; Allomyces.
OX   NCBI_TaxID=578462 {ECO:0000313|EMBL:KNE67763.1, ECO:0000313|Proteomes:UP000054350};
RN   [1] {ECO:0000313|EMBL:KNE67763.1, ECO:0000313|Proteomes:UP000054350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 38327 {ECO:0000313|EMBL:KNE67763.1,
RC   ECO:0000313|Proteomes:UP000054350};
RG   The Broad Institute Genome Sequencing Platform;
RA   Russ C., Cuomo C., Burger G., Gray M.W., Holland P.W.H., King N.,
RA   Lang F.B.F., Roger A.J., Ruiz-Trillo I., Young S.K., Zeng Q., Gargeya S.,
RA   Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA   Berlin A., Chapman S.B., Gearin G., Goldberg J., Griggs A., Gujja S.,
RA   Hansen M., Heiman D., Howarth C., Larimer J., Lui A., MacDonald P.J.P.,
RA   McCowen C., Montmayeur A., Murphy C., Neiman D., Pearson M., Priest M.,
RA   Roberts A., Saif S., Shea T., Sisk P., Stolte C., Sykes S., Wortman J.,
RA   Nusbaum C., Birren B.;
RT   "Annotation of Allomyces macrogynus ATCC 38327.";
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000054350}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 38327 {ECO:0000313|Proteomes:UP000054350};
RG   The Broad Institute Genome Sequencing Platform;
RA   Russ C., Cuomo C., Shea T., Young S.K., Zeng Q., Koehrsen M., Haas B.,
RA   Borodovsky M., Guigo R., Alvarado L., Berlin A., Borenstein D., Chen Z.,
RA   Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S.,
RA   Heiman D., Hepburn T., Howarth C., Jen D., Larson L., Lewis B., Mehta T.,
RA   Park D., Pearson M., Roberts A., Saif S., Shenoy N., Sisk P., Stolte C.,
RA   Sykes S., Walk T., White J., Yandava C., Burger G., Gray M.W.,
RA   Holland P.W.H., King N., Lang F.B.F., Roger A.J., Ruiz-Trillo I.,
RA   Lander E., Nusbaum C.;
RT   "The Genome Sequence of Allomyces macrogynus strain ATCC 38327.";
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to the 60S ribosomal subunit and prevents its
CC       association with the 40S ribosomal subunit to form the 80S initiation
CC       complex in the cytoplasm. Is also involved in ribosome biogenesis.
CC       Associates with pre-60S subunits in the nucleus and is involved in its
CC       nuclear export. {ECO:0000256|HAMAP-Rule:MF_03132}.
CC   -!- SUBUNIT: Monomer. Associates with the 60S ribosomal subunit.
CC       {ECO:0000256|HAMAP-Rule:MF_03132}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03132}.
CC       Nucleus, nucleolus {ECO:0000256|HAMAP-Rule:MF_03132}. Note=Shuttles
CC       between cytoplasm and nucleus/nucleolus. {ECO:0000256|HAMAP-
CC       Rule:MF_03132}.
CC   -!- PTM: Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.
CC       {ECO:0000256|HAMAP-Rule:MF_03132}.
CC   -!- SIMILARITY: Belongs to the eIF-6 family. {ECO:0000256|HAMAP-
CC       Rule:MF_03132}.
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DR   EMBL; GG745354; KNE67763.1; -; Genomic_DNA.
DR   EMBL; GG745365; KNE70310.1; -; Genomic_DNA.
DR   STRING; 578462.A0A0L0SYX5; -.
DR   EnsemblFungi; KNE67763; KNE67763; AMAG_12487.
DR   EnsemblFungi; KNE70310; KNE70310; AMAG_14456.
DR   VEuPathDB; FungiDB:AMAG_12487; -.
DR   VEuPathDB; FungiDB:AMAG_14456; -.
DR   eggNOG; KOG3185; Eukaryota.
DR   OMA; GCRIVGR; -.
DR   OrthoDB; 5473211at2759; -.
DR   Proteomes; UP000054350; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0042256; P:cytosolic ribosome assembly; IEA:UniProtKB-UniRule.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:UniProtKB-UniRule.
DR   GO; GO:0000054; P:ribosomal subunit export from nucleus; IEA:UniProtKB-UniRule.
DR   CDD; cd00527; IF6; 1.
DR   HAMAP; MF_00032; eIF_6; 1.
DR   InterPro; IPR002769; eIF6.
DR   NCBIfam; TIGR00323; eIF-6; 1.
DR   PANTHER; PTHR10784; EUKARYOTIC TRANSLATION INITIATION FACTOR 6; 1.
DR   PANTHER; PTHR10784:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 6; 1.
DR   Pfam; PF01912; eIF-6; 1.
DR   PIRSF; PIRSF006413; IF-6; 1.
DR   SMART; SM00654; eIF6; 1.
DR   SUPFAM; SSF55909; Pentein; 1.
PE   3: Inferred from homology;
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03132};
KW   Initiation factor {ECO:0000256|ARBA:ARBA00022540, ECO:0000256|HAMAP-
KW   Rule:MF_03132}; Nucleus {ECO:0000256|HAMAP-Rule:MF_03132};
KW   Phosphoprotein {ECO:0000256|HAMAP-Rule:MF_03132};
KW   Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917, ECO:0000256|HAMAP-
KW   Rule:MF_03132}; Reference proteome {ECO:0000313|Proteomes:UP000054350};
KW   Ribosome biogenesis {ECO:0000256|HAMAP-Rule:MF_03132}.
FT   MOD_RES         174
FT                   /note="Phosphoserine; by CK1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_03132"
FT   MOD_RES         175
FT                   /note="Phosphoserine; by CK1"
FT                   /evidence="ECO:0000256|HAMAP-Rule:MF_03132"
SQ   SEQUENCE   245 AA;  26452 MW;  E410F2B5174331CC CRC64;
     MAVRAQFENS NDIGVFARLT NSYCLVAVGG SENFYSVFEA ELGDVIPVIH TSIAGTRIIG
     RLTAGNRHGL LVPNTTTDQE LQHLRNSLPD KVAVQRIEER LSALGNVIAC NDYVALVHPD
     IDRETEEIIA DVLQVEVFRH TVADNVLTGS YAVISNQGGM VHPQTTLQDQ EELSSLLQVP
     LVAGTVNRGS DALGGGLIVN DWAAFVGYDT TGTEMSVIES IFKLHDAGAQ AIVTDMRDSL
     IDSMM
//
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