ID A0A0L0VX76_9BASI Unreviewed; 642 AA.
AC A0A0L0VX76;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 13-SEP-2023, entry version 36.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:KNF03610.1};
GN ORFNames=PSTG_03133 {ECO:0000313|EMBL:KNF03610.1};
OS Puccinia striiformis f. sp. tritici PST-78.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Pucciniomycetes; Pucciniales; Pucciniaceae; Puccinia.
OX NCBI_TaxID=1165861 {ECO:0000313|EMBL:KNF03610.1, ECO:0000313|Proteomes:UP000054564};
RN [1] {ECO:0000313|Proteomes:UP000054564}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race PST-78 {ECO:0000313|Proteomes:UP000054564};
RG The Broad Institute Genome Sequencing Platform;
RA Cuomo C., Hulbert S., Chen X., Walker B., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Haas B., Abouelleil A., Alvarado L., Arachchi H.M.,
RA Berlin A.M., Chapman S.B., Goldberg J., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Larimer J., McCowan C., Montmayeur A., Murphy C.,
RA Neiman D., Pearson M., Priest M., Roberts A., Saif S., Shea T., Sisk P.,
RA Sykes S., Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Puccinia striiformis f. sp. tritici PST-78.";
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU004254}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNF03610.1}.
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DR EMBL; AJIL01000016; KNF03610.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L0VX76; -.
DR STRING; 1165861.A0A0L0VX76; -.
DR OrthoDB; 1381745at2759; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000054564; Unassembled WGS sequence.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00537; MTHFR; 1.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR004621; Fadh2_euk.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR NCBIfam; TIGR00677; fadh2_euk; 1.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF3; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000054564}.
SQ SEQUENCE 642 AA; 72276 MW; F463FD3F0D7B4B87 CRC64;
MKISQKLAAA ESENRISWSF EYFPPKTDNG LTNLYDRIYR MSQLGPIFID ITWGAGGSTS
NLTTEFVKTA HEQFGLETCM HLTCTNMPKE KIDTALKEAY EFGCENILAL RGDPPKGSTE
WTATEGGFEH AIDLVRHIRA GYGDHFDIAV AGFPEGHMHS SLTKEQETIY LKEKIDAGAN
FIFTQMFYDV DIFIDWVREI RAAGITVPVI PGLMPIQSWA QFKRVTNFSK TIVPQYFLDT
LEPIQSDDQA VREAGTKLVA DMCRKILNSD LGIRILHFYT MNLERGTKML LDELNLNPSR
DITNPLPWKM SLLGKRRSES IRPIFWANRA KSYLSRTETW DEFPNGRWGD SRSPAYGELD
GYGININSAT IETLKGLKKF PTSLEDLARI FANYCGARFP GEEPVKYLPW SDIALSEETG
KIEDVLVKIN KRGFLTINSQ PAVDGAKSSD PVHGWGPRGG YVYQKAYLEF FCCPEKFQSL
TERLEQDPDV TYYAVTKTGD LVTNNTRPGP NAVTWGVFPG KEIVQPTIVE LVSFIAWKDE
AFELGHQWAE LYKDTAPESS KFIHEIMDSW YLVNIVNNDF RKSNDDSENS ALFQFFGPEP
VIVKEDGVPS TNGFHHSNGI SKVNGTSVTV NGLNGDINNL AI
//
