ID A0A0L1I4D2_PLAFA Unreviewed; 1562 AA.
AC A0A0L1I4D2;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=PFMG_00642 {ECO:0000313|EMBL:KNG74484.1};
OS Plasmodium falciparum IGH-CR14.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=580059 {ECO:0000313|EMBL:KNG74484.1, ECO:0000313|Proteomes:UP000054562};
RN [1] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Godfrey P., Alvarado L.,
RA Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA White J., Yandava C., Wirth D.F., Nusbaum C., Birren B.;
RT "The genome sequence of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a
CC 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP +
CC H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216;
CC EC=2.7.1.67; Evidence={ECO:0000256|ARBA:ARBA00001686};
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DR EMBL; GG664988; KNG74484.1; -; Genomic_DNA.
DR SMR; A0A0L1I4D2; -.
DR EnsemblProtists; KNG74484; KNG74484; PFMG_00642.
DR Proteomes; UP000054562; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05168; PI4Kc_III_beta; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR049160; PI4KB-PIK1_PIK.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF22; PHOSPHATIDYLINOSITOL 4-KINASE BETA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 2.
DR Pfam; PF21245; PI4KB-PIK1_PIK; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:KNG74484.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054562};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 286..488
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1282..1547
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 94..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 283..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 571..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..662
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 871..912
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 955..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1040..1105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1203..1243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 231..258
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 14..31
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..112
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 131..164
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 871..906
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 963..981
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1041..1075
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1223..1243
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1562 AA; 183039 MW; 603361EA2D26FCFF CRC64;
MEDDKDNNIT KENLNEVDIE NSQDNNITKE NLNEVDIENS QLPIIEEKNL KEEGVKDEGG
KVFLKGEPIH KHLYKHSYNT QVYKDEVTHM RLRENKNLNE NNSDDNKKVN KKNGCADINM
NEHTNKKEDG DDDDGDDDDD DDDDDGDDDG DDDDGDDDGD DDSNSNDDIK NNHKYNNDDY
HKNMIKLHCT SPKKKEHSIN NNNIVSHNEI EENLKDHTLI TNDEEKNIKI IEMYEKKLEN
EEIKKQNKED ANENNKSQIR ESISKIFKEC PTSKPKIINE INNETKYDNN NNNNNNNNSN
NNNKNNNKNN NKNSSYNNYY YNNIYNCNNM KENNHIDGDK NNIYETNNYS DSEKNKSSDT
EKNKLKLNNK NTLKEGSLLR LFRCEYFDTH LHIRYLYDRK EVGVHEYLVN SLYTQRKYED
ILFYLPQLSQ ISLVRYESSS LYRFLLEKAS KSMHFALKLS WLYHSIVEDN SSKYKDLAQR
MIQEIEMAVV NCKPLNNECK SFEENKQSYL LDLAYPLLFK RKFILKKIKT NEKLNKIKMY
NKCLNNSYNS YTLKNLHVSN PIEMDTTSFL RNHKNSNDST LSQGLPNKSS NDDNCNVLKR
EDHQDVINIS SEENEERDIN KNLKEEVTTL DDNKISRENN LQNLQSEKKT PILKRKNLKQ
AHTTPCPKLP PCYIINSGSL SIARAKVKLP STYSKLGNPL SFSKFSLPDF NYSYDMIEEL
QQFFMKQRRC DYFSLLNNFI NLLISVSNLL AAEPDIDLRN ELLRRFIYSL NSWMNMRRCI
VACCENIFAM TGLCIPLESM SSSTFNHDTN NRLSYNNLQI LHFNNEECKI FFSKKRAPYL
LMFEVADLDE DISHISDNIF YTKKSLFFQQ DNNNNNNNND NNNNNNNNNN NNYNCNNNNY
NSDVQSKEPK NVREEYSRKS LILSRNFCCS KNYGYYEENL NTFDYENRLS LEDKKKKNSK
KKKYAKEQEQ TNNEKLKDKE KERKKKNIFD LNSLKMDDIY VYNCIVNDLR RENLISFTSK
EDENLALIKK CLGLKMVEEE KNENDDDDND DDNDDDNDDD NDDYNEEEED DNYEKKNFEE
EQKGNYNNDN INHNEKKKKV PTANDNLSSS SFCVKKNYLL NSRSVSMPSY LNNNLEKCDT
SSYDNTSNNI KTSIETISNG IDDIQVEKNI EKNETFEEMK RKNSNNEFID YNEHMVKLSP
YYTTTNHRGK NKNDDTDDNS DDDNINNYNN NNNSGNNNQD NTISNFPNNI LDLSEYFKPE
NYLNEEFKKK NCKIIKRLLW GELFEEKKKR IRKVSPYGKL KTWDLKCVII KGGDDLRQEL
LASQLIKQFK IIFENAGLPL WLRPYEILVT GSNSGIIEYV NDTCSVDSLK RKFGADSIST
IFNIVFSDYI FEAKKNFIES HAAYSLISYL LQVKDRHNGN LLLDSDGHLI HIDYGFMLTN
SPGNVNFETS PFKLTQEYLD IMDGEKSDNY EYFRRLIVSG FLEARKHSEE IILFVELMMP
ALKIPCFANG TQFCIESLKE RFMTNLTVDV CIQRINALIE ASINNFRSVQ YDYFQRITNG
IM
//