ID A0A0L1I642_PLAFA Unreviewed; 1473 AA.
AC A0A0L1I642;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=PFMG_00769 {ECO:0000313|EMBL:KNG74680.1};
OS Plasmodium falciparum IGH-CR14.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=580059 {ECO:0000313|EMBL:KNG74680.1, ECO:0000313|Proteomes:UP000054562};
RN [1] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Godfrey P., Alvarado L.,
RA Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA White J., Yandava C., Wirth D.F., Nusbaum C., Birren B.;
RT "The genome sequence of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|RuleBase:RU004070}.
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DR EMBL; GG664999; KNG74680.1; -; Genomic_DNA.
DR EnsemblProtists; KNG74680; KNG74680; PFMG_00769.
DR Proteomes; UP000054562; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630:SF48; DNA HELICASE MCM9; 1.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Reference proteome {ECO:0000313|Proteomes:UP000054562}.
FT DOMAIN 1020..1199
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 146..252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1004..1026
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..171
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..252
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 526..540
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1473 AA; 172181 MW; 8BDAF779385BC81A CRC64;
MTLSSSESSI FSETDDDSYK EEDYTYNRDE NIKNIKIYNK IIIKLFLKNR KYYEQIKRIA
LGYISKIEDI EFCNVQNNEQ DRNEHIYNFY FDAHDAIEYG ENKLIYYLQN SYHKFMDVIN
NYSIPLFFRI IFLSCYFEFL NNEENEKKNN DDNKNNDDNK NNDDNKNNGD NKNNGDNKNN
GDNKNYGDNK NYDDNKNYGD NKNYDDNKNY GDNKNYDDNK NYDDNKNYDN NDNDICNDNE
RKQGEEENNK DNNYYLDSNI LHFHNVTTSP SNCLKEDFEL FRTNENDMYE KENEHLWQDK
NEEYNNIHNE KYINDKNSIN NDDTKKKKKK TLDQVGKGRV KENDMDYFFN NFIEYDFCKD
NDVMEQIDLY SSCLIKGILF SYMKYTFLKK EEIKLKINNC LKMIFVRHNI KIKCRLINIP
YLHDIHINNI QEIENKHIGK FISTEGIITR VGEKKILEES KKYRCMRCDY VIKKNAAPEL
YYNTETFFRC PNIIVNTKKM SSDILYDIND KITKEFITKK MDKNKKKDDS VDHNFEDDND
NNHYNNPLYS NRTNQNEKGI YVKKRCNSTN FEFIENEIKR VDYQEIKIKE TSKSNIPYSI
TVVLLENLAG KYHPGKNVII NGIVLRRWKR LYKDIRCDSE LFIEANYIEI KELEQIKIKE
ISLDDDFSKY INSIVSKACL RDQQSVFCGE EEFMENASCG GNDNLCEQME YDICSNKRGN
INVDDINVDN INGDNINVDN INGDNINGDN INGDNINGDN INGDNINGDN INVDNINGNN
INVGDKQICD SRGDDSPILK DINTVPQDNQ CYPINTRLIP QNKRRKDEHI NRQVNHISFT
HLNSVDKREN VFEKYWFFFE NNKIEGKKYI CESICPNLYN CKLSKLSILL VLIGGNKINN
EYESFYHENN KWIKYFSKNY KKSKKKSSIG NVVRDNLNVN EENEMVEDSY EEDSLEEMGE
RIRKKTRKGN KNEVKKNDIY QKENNIYNLY KTNNISNIQY DEMENTKEKR KRKQRQKQKQ
KQTKFESDNC DKRTLCHLLL VGDPGTGKSQ LLKEVQKLSN ICVNVSGMFC TTAGLTCAAI
KEGNSFMLES GALVLADNGV CCIDEFCLMK NENKNAIHEA MEQLSISVAK GGIVDKLNCR
CTIIGASNFE INKEVKGNLS NYDSKVIIIN LSYALLSRFD LVVIAEDNSQ IDYKIADYIL
SQDVEVKKGL DNEYVNNNDN IKNNVLDKNN MNSNMNNCKS TTCNNYTENN HLENLPGSYI
NNGHKKHNEP IGHDSIILSP FNSDNGNGGT FEKKQNKINK INKINKINKI TWPSEKLKEY
INYVKNGFFP NFDKSSKLIL ITYYSTLRKY NDGDNGTTVR TLESLIRLSE AHSKLILNKK
VTSDDVINII LLVELSLRGY QIAIRTNANN ILIARTGILE NSAYLLQTYN SNYNTFYCLD
DVLFDDSLYI YFKNIILEKL QLQEINGKIH KML
//
