ID A0A0L1I6Y6_PLAFA Unreviewed; 2395 AA.
AC A0A0L1I6Y6;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=SET domain-containing protein {ECO:0000313|EMBL:KNG74960.1};
GN ORFNames=PFMG_01194 {ECO:0000313|EMBL:KNG74960.1};
OS Plasmodium falciparum IGH-CR14.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=580059 {ECO:0000313|EMBL:KNG74960.1, ECO:0000313|Proteomes:UP000054562};
RN [1] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Godfrey P., Alvarado L.,
RA Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA White J., Yandava C., Wirth D.F., Nusbaum C., Birren B.;
RT "The genome sequence of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; GG665017; KNG74960.1; -; Genomic_DNA.
DR EnsemblProtists; KNG74960; KNG74960; PFMG_01194.
DR Proteomes; UP000054562; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR015947; PUA-like_sf.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR PANTHER; PTHR45660; HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR; 1.
DR PANTHER; PTHR45660:SF13; HISTONE-LYSINE N-METHYLTRANSFERASE SETMAR; 1.
DR Pfam; PF00856; SET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF88697; PUA domain-like; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000054562};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2248..2375
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 2379..2395
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 83..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 255..383
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 474..510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 556..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1112..1161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1303..1333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1557..1625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 282..305
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..338
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..379
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 474..492
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 493..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1577..1620
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2395 AA; 282822 MW; 5412BF661E507AC9 CRC64;
MLNDMNDKKD SIRNRNYKKN KKDEERNIRK YSNDNINVVN NMKDIYNNNN NNINKSVIDC
GNNLKRIEGK KVFERNKFGQ FIKKSNSPSL KDTNIKSNNN KNMKNTNHNN EENNNNNTNN
TLSNKEKIKV LIDKMKKIQN KKEVNKTLDK PMYIRNFQDE KKVSTHNNAY KLKRNGDPRN
YGDIKNGDNI KNGDNNKNGD NIKNGDNIKN GDNIKNGDNI KNGDNIKNGD NIKNGDNIKN
GDNIKNGDDQ IIGCLKNNRE PRSNVENETN EMSNSYGKFT KNRDLKNSDK IKMNDEYRRN
NDANISDYNK KNNNNNVNKS NNVVRSSDES LSSDTINKSD CKNKVEENSS RNADESHKKE
DGDLINKDKD EKEGENLSVP KESNETYYRI SRRERCRNLK KEDNLKIIND EDNSVSHFIK
EGRKRSVRER SNLRNYNYIN VNNNIKDDDF VDEPNNGSSI IKMNERKKTI LRRGARHRRR
NPRKRRRRCS SLRNNKNTIN SVTKSNYDMS DGDNYEKGRK FLYDNSSNYN ELDPLNSKFS
NIKISKNFFL KMNDDEDEED EDGVGDDDKT SKNSSYSFGF NERNIEKKII ILEQKDGIYE
INENYLKYDN MKDMEDRKNM EDMKNMEDRK NMEDMKNMED MKNMEYMKNM EYMKNMEDMK
NMEDMKNMED MKNMEDMKNM EDMKNMEDDN KKDYMNDNLK DDIVIKDNIV IKDDIVMKDN
IVMKDNINDS VKDNINEELE NNETSCKSSK LNDVTHNNNN ICDDNNIVSH SNGEMKEVNI
MYPINNEINI KKKRILNNDE ILILLNLLRD ININRFNIKH VMTSKDCMYE KFMLYNLFSY
NITCLKSSLK MMYAYCLFKN LKLFYQIQYK NMNMTEKSIP NYKIKNNLLD THCIILSMFE
NYYENVSKKK MPIADFINSF YLNIHNINIG KKKVQPNKNY ENIVLPEKDN RKITSMYTNK
SLLYSNYMNK DINMENKAYK LNDINMENYR SDHKNNTFID NDCNNNHKYN NICKNELNSC
ISNISNDPNN NKNVHTMNKD LYGNIYTEQN AYHVHNYKDM RNEHENNNNI KKKDNIENSI
YYDNKMYLGA NEKTPCLKDI HMNKNYEQTY DNYDGTNGYN NNNKKKNDNK KNDNNNNDNN
NNDNNNNDNQ DDNHHDNNKE EYNNQNHLFL NNESRKRKFF TNILPYKNKK KKLPYTINLN
NDNKTYHHES INNENHMPLW DYKELENIKN MINDEKDEED CTPLAHSIKI TKNYDNINMD
ECNVRNENQE YKDNVTNYKV CQDGNFECYD VNESVLVRDI HMEKNNNVEK NNNVEKNNND
EKKNNDEKNN DDNNNIIEKA KENIESIPYD KNCSQDNIQY NMAYKDTSLL LCEQRDMDKG
NKKEDDTIKM EDIHFSADME CSPMLKYRKR NYDNKNDDDY VKDDDGCVKN DDGCIKNDDG
YIKNDDGYIK NDDGYIKNDD GYIKNDDGYI KNDDGYIKND DDYNNNGEYL HGSDNNLSAH
KYNSVCRRRR RVDRNKESNE KEKRVYRNDI MELENVDVML LERIKKNYKM LIRNDNENKK
KKKKNNGTVT ILEDVDNVYD DNNNNNNNDN NIDNNNNNNN NNNNNNNNNN VESHNNNNNE
RGSTKIEKCR KNKITFFNKY SKLLNNDNVD KKKSKYMLTT ESLYNNNFNI LDIKVNTHFA
HNYHISLFFF CKYTSYNLYL HPLNKNEHIV SYVILNSKNE VLTDNGNSFV LRYLLSFLTN
KISSLRKCYA NALYNSYLLQ IPIRIFRHHN LENKYSPQYG IRYDGIYKII NAFTINDYST
PEYKRDILYV FKRLYVDKCF IPNMNPKILD KQDKAERKKN FIEKNSVSIN VMMNKEIIMT
LRIPYLKNYK STTFTNFNHI YKFIKKKCIQ KKKAMPWIQS EVSIYEACMQ HIKKTEEKKK
EHFLNSQKMN NIKTNVNNTN DIYNNENLNS GDDAFKDCIQ AINVDKSVQQ INDVRFDMND
GNYKMGDIKK ECSNVYENMF PAKNNNKIDI NKININSNHF SNSSNNNNCD NYKRLGEPNF
PYWCLGKYLP FVLVLETLNF EKEIDIYKGI RTKNLKNLKI SIIKTEIPIN CEMAKRPAHL
FIPIKSKEAI SAYIELKKPY DNHWNPYEDL SGGKEIFKIP VENVVDESLP PMNFTYVNKT
IFFSRLPPYN LLPLCSGCAP HNYNKKEYVD LYINGYCKGI RHKKTNRIYC DGNKNYDIND
FNVLAACSGN CLCDPLKCTN KFPEGLHYPI KVVKTKDIGW DIVSCSFIKA NSLIMHYVGE
ITTRKEMISR EHEYDKKGYF NYFIETAEVD ETYPDDWKIP CIDALFISNV ARFLNHSCEP
NVNVITIWRG DNYPSVGIFA SRDIQPNEPL KYHYGINYKN IKCMCASKKC KGYIG
//
