ID A0A0L1I7K0_PLAFA Unreviewed; 2249 AA.
AC A0A0L1I7K0;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=DNA repair protein RAD50 {ECO:0000313|EMBL:KNG75118.1};
GN ORFNames=PFMG_01326 {ECO:0000313|EMBL:KNG75118.1};
OS Plasmodium falciparum IGH-CR14.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=580059 {ECO:0000313|EMBL:KNG75118.1, ECO:0000313|Proteomes:UP000054562};
RN [1] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Godfrey P., Alvarado L.,
RA Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA White J., Yandava C., Wirth D.F., Nusbaum C., Birren B.;
RT "The genome sequence of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the SMC family. RAD50 subfamily.
CC {ECO:0000256|ARBA:ARBA00009439}.
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DR EMBL; GG665027; KNG75118.1; -; Genomic_DNA.
DR EnsemblProtists; KNG75118; KNG75118; PFMG_01326.
DR Proteomes; UP000054562; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR GO; GO:0006996; P:organelle organization; IEA:UniProt.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR PANTHER; PTHR18867:SF12; DNA REPAIR PROTEIN RAD50; 1.
DR PANTHER; PTHR18867; RAD50; 1.
DR Pfam; PF13304; AAA_21; 1.
DR Pfam; PF13476; AAA_23; 1.
DR SUPFAM; SSF58104; Methyl-accepting chemotaxis protein (MCP) signaling domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Meiosis {ECO:0000256|ARBA:ARBA00023254};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000054562};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 6..240
FT /note="Rad50/SbcC-type AAA"
FT /evidence="ECO:0000259|Pfam:PF13476"
FT DOMAIN 2022..2220
FT /note="ATPase AAA-type core"
FT /evidence="ECO:0000259|Pfam:PF13304"
FT REGION 489..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1913..1942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 678..705
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1795..1825
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1983..2014
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 490..602
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2249 AA; 269626 MW; 29F3320798723A86 CRC64;
MTTLEKIGIQ GIRSYNDEDV EILEFATPIT IIYGNNGSGK STIIECLKVS CTGDFPPNAE
KGKSFLHDPL ISNKMNIRGK IDVLLNNYNN KRIGISRSYN LFYSKDKNKK VKHTFRALDN
NIIIKKEKGD DLIITNKCVD INNHIPKLMG VSKALLENVI FCHHDENLWP FSESIKIKKK
FDELFGDDHF SKILEELLKC KKYLNDLLKR KEFDLIHIKE NFEKKKNIYI EIEKNEKEIQ
SAQICIQLDV EEIEENTIIL NNLIKKKNLL YKLIGNIDSY FLLYTKFKVD AEAYKDLKEV
YEENYTELLY FQEVFNNDIN KCEICIQKVK QDIQNLQHEK DTCMFNYNES NKYDDNYELS
KKQLNEYIIK RDDIRNKLKD IFFYNDQIFF SNYKGNSSSD MIKHSSINEG HQKEKLKKKF
KKHDSVYIKD HLLKEYENLL HMYDIHKEDI ALYNHDVMLS YKNEEHIPSN ARLMEELFLI
CQNKVQYKTS NKSDDNKRNN NNNHFDDDNK RNNNNNNFDD DNKRNNNNNH FDDDNKRNNN
NNHFDDDNKR NNNNNHFDDD NKRNNNNNHF DDDNKRNNNN NHFDDDNKRN NNNNHFDDDN
KNKCDDKKFI EIPNVSNILS NVPYLKKKHE KKINSIRYIL KRHISHIKRN KYKKRNVIYK
IKNYKKRLLK IEKNITLLDI YKNKLNKLKS NEIIYEQNLK KIEKLNQLKC LYDNLTTLDN
EMDTYNIQKE NNYYEEQIEK NMKQINDIQK LKIWIHTFCN IIRNYNIFYE FIQRCKKIHE
HCVIFFDILF SLLDVIKTDF YKIVDMLKER DMDLYYYIER GMQKKINVER NVCVERNVCV
ERNVCVENNI CVEKNICVEK NICVEKNICG EKKKITKLKS NIEIEESVEK IKDNKINECD
VNVDTLNKTN SIHHVNNIKI NSKSLVCMNE HLQRKRENEK LNDYTCKLKK QKTHLDISIL
KNRKYLDILL NIINIFIDKY ENKINNIKTL IIPLNQKVLE ISKKLNNMNN NINEYKNYLS
NFIHMLKEKK YKDVKDFVNY VEAIDNQIKI KKKNLWMLNG KEDLMNEFKN HLKSDEQNNS
DNNKKVGVEK KKKKNCLFCK NTISQNNKDI VQIEMYIEEQ KRDMLKKIEE SEKDINILKN
KKEENIILLN YYYYHIKHIH TYTNDSNEMI VKLKEELLSA QDSIEKYNIK IKNIHRKFQL
VQKFKETCVY LINIQKDILD VEKYIKDESI KIKGNFQEMK NKIKDNVENN KMSNNTNKCN
DTKTCNNTKT CNNTYTCDHL FIEKLYHMIE NLDISIEVKE SNLLKNIKEF VKKFAKYNNK
DIINIFYNKI CTSNVNDSYS YIPYNDIINV DLYQQYNYQN NYKDRFKYNL YKINNANYIC
KLLSPHQKVS LKDCYSSDQT PQKIYVDEEK EKEKEKKKKK KKKKTDNDGY YDEIFHCDNM
EYDEQFYEDD DHHSYNKSKS LIENYITPCK NKEESVKEPN MCSIKHIYDN GSSNDDILNN
DKTVLLNKIN SSYLSFVLNI GTSYYSNEEI KENNKNDTNK MCDDTNKMYD DTNKMYDDTN
KMYDDTNKMC DDTNKRYDDT NKMCHDTNKM CDDTNQMYDD TNKRYDDTNK RYDDTNKMCD
DTNQMYDDTN KRYDNINQNT YGTFLKCSDF LHNLPSIILN NKHFEKMYRN FLSYLNVEEY
TRKEQNKMIE KMKVVIKDRR AYVIKKSKVL EKTINIDKRI RDLIKKMDIY ILYYKEKKKK
IIDEKINVKN LLIEQRDTQL KYIKRCIRNN KKSIFLEKRN YYLKMNMIYI LIKKLKHTEE
EIVNKEKYLK DVKEKLNNNE IIKNQVICID KKINEKKEHI LCLEKEKINI EKMLHNIIMN
TNMKKMYEQF LEHHQTFILS LNQLKASFFL YERKNIKNSN MCKLEYKDEI NGDKKKENDN
TVSSNNDSII NNDNRNKKNR YNDEENGINY INDIVKKLEE NYNNNTNIYN FINKTFDITD
CLKNRLKDII KIEEDDLNEQ IEKYTKSITA LKIKEAEMNG KICLRKEYLE KLKEDIKSET
LINIDKEYKK KIIEIFVYKN LIKDLQNFHF SFDQAIIKFH SLKMQEINLS IKNLWRRVYN
SADIDYIYIK SDIQTEPTDK SSQRRSYNYR VVMVKDNCEL DMKGRCSSGQ KVLSSIIIRL
ALAESFSIKC GILALDEPTT NLDKANSRNL ASLLANIVEL RKSSSSFQLI LITHDNYFVD
ILSQYGLTNC FYKIKKNNLG YSKIERVNT
//
