ID   A0A0L1IB27_PLAFA        Unreviewed;       922 AA.
AC   A0A0L1IB27;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   SubName: Full=ATP-dependent heat shock protein {ECO:0000313|EMBL:KNG76343.1};
GN   ORFNames=PFMG_02461 {ECO:0000313|EMBL:KNG76343.1};
OS   Plasmodium falciparum IGH-CR14.
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=580059 {ECO:0000313|EMBL:KNG76343.1, ECO:0000313|Proteomes:UP000054562};
RN   [1] {ECO:0000313|Proteomes:UP000054562}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG   The Broad Institute Genome Sequencing Platform;
RA   Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA   Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA   Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA   Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA   Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA   Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT   "Annotation of Plasmodium falciparum IGH-CR14.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000054562}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG   The Broad Institute Genome Sequencing Platform;
RA   Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Godfrey P., Alvarado L.,
RA   Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA   Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA   Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA   Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA   White J., Yandava C., Wirth D.F., Nusbaum C., Birren B.;
RT   "The genome sequence of Plasmodium falciparum IGH-CR14.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the ClpX chaperone family. HslU subfamily.
CC       {ECO:0000256|ARBA:ARBA00009771}.
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DR   EMBL; GG665147; KNG76343.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0L1IB27; -.
DR   EnsemblProtists; KNG76343; KNG76343; PFMG_02461.
DR   Proteomes; UP000054562; Unassembled WGS sequence.
DR   GO; GO:0009376; C:HslUV protease complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0008233; F:peptidase activity; IEA:InterPro.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003959; ATPase_AAA_core.
DR   InterPro; IPR019489; Clp_ATPase_C.
DR   InterPro; IPR004491; HslU.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR00390; hslU; 1.
DR   PANTHER; PTHR48102; ATP-DEPENDENT CLP PROTEASE ATP-BINDING SUBUNIT CLPX-LIKE, MITOCHONDRIAL-RELATED; 1.
DR   PANTHER; PTHR48102:SF3; ATP-DEPENDENT PROTEASE ATPASE SUBUNIT HSLU; 1.
DR   Pfam; PF00004; AAA; 1.
DR   Pfam; PF07724; AAA_2; 1.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM01086; ClpB_D2-small; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000054562};
KW   Stress response {ECO:0000313|EMBL:KNG76343.1}.
FT   DOMAIN          530..811
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          814..910
FT                   /note="Clp ATPase C-terminal"
FT                   /evidence="ECO:0000259|SMART:SM01086"
FT   REGION          303..325
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        310..325
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   922 AA;  106494 MW;  C9CECC3E0518459D CRC64;
     MKNLDANKCI KLINGLKQKK NYPYFSLQCL KNISNEKEKI HDKLLTFIPN NSRKIINSGT
     KSNYDSRFDK LIQNNKNNKN YNNINYKVID HNKSNEECNV KNNFSINNKN VHISDINVKQ
     KDKGDDLVIH IKYEPDNNKN GKKNEGQQIL YNYDEMNYGN EDKTKLYIMN NYDEVGTKCN
     YKEYMSYNMN PHEYGKREDV NINGNNINNI NNINSMNNIN NINSINSINN NNINNSYNSY
     NNCKYINNNN NNDYNNFSRH GEKQKKYTMF LKKDDISKNI DQKEHINNLN SINNLDNMNE
     TCDDTTSCTH SKNTRSDKKT DASISGKDDI VRDSYSSDKK KENMENFAKV KITKENIINI
     NEIKEEDVKK VKKVMGHKKE TNEYNIKDEK NDNIYDIKVD IKKEEKDNIY DIKVDIKNEE
     LPKSTIASEV PNHNSNVLKN DNIGKKNYFS SGSMKSGNVL KEEIKSDDSK INFQMKNGKS
     SKKCLYPHEI VEYLNKYIIG QSEAKKVVAN ALRQRWRRIQ VSDDMKKDII PKNILMIGPT
     GVGKTEIARR ISMFVDAPFI KVEATKFTEV GFHGKDVDQI IKDLVEIAVK RQKTKFEIEI
     REQAEETVEN IILYSLLGNI KEEEKNIWRK YLKDGSLDDK VISIDIPNYI NNNIFSNDSV
     ENAVKEALSN HQNIKSVKII HQNINKQSDK KTMTIREARQ KLLQLEIDSS INQDTILKTA
     INSVEEEGIV FIDEIDKICS KSNSSYNGPD ASAEGVQRDL LPLIEGCVIN TKYGNINTNY
     ILFIASGAFQ RVKPNDMLNE LQGRLPVHVT LSSLTIKDFI DILTKTHNNL LQQNIALLKT
     EGIDLKFTDD AIETIANAAH DMNFYVENIG VRRLHTIIEK IMEDINYDVY NYVNQSIVID
     KDKVNKSLEG FIKQYDLKKY II
//