ID A0A0L1IBN8_PLAFA Unreviewed; 1005 AA.
AC A0A0L1IBN8;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=PFMG_02845 {ECO:0000313|EMBL:KNG76922.1};
OS Plasmodium falciparum IGH-CR14.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=580059 {ECO:0000313|EMBL:KNG76922.1, ECO:0000313|Proteomes:UP000054562};
RN [1] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054562}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IGH-CR14 {ECO:0000313|Proteomes:UP000054562};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Godfrey P., Alvarado L.,
RA Berlin A., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M.,
RA Goldberg J., Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C.,
RA Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A.,
RA Saif S., Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T.,
RA White J., Yandava C., Wirth D.F., Nusbaum C., Birren B.;
RT "The genome sequence of Plasmodium falciparum IGH-CR14.";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|ARBA:ARBA00008010,
CC ECO:0000256|RuleBase:RU004070}.
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DR EMBL; GG665223; KNG76922.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L1IBN8; -.
DR SMR; A0A0L1IBN8; -.
DR EnsemblProtists; KNG76922; KNG76922; PFMG_02845.
DR Proteomes; UP000054562; Unassembled WGS sequence.
DR GO; GO:0042555; C:MCM complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR Gene3D; 2.20.28.10; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR008047; MCM_4.
DR InterPro; IPR018525; MCM_CS.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR PANTHER; PTHR11630:SF66; DNA REPLICATION LICENSING FACTOR MCM4; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR PRINTS; PR01660; MCMPROTEIN4.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00847; MCM_1; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070};
KW Reference proteome {ECO:0000313|Proteomes:UP000054562}.
FT DOMAIN 516..722
FT /note="MCM"
FT /evidence="ECO:0000259|PROSITE:PS50051"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..745
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1005 AA; 115217 MW; 6FB240AAB02F03EC CRC64;
MGTPRRRLGQ QNNNNNSPFA LSSSNIFGSN NEIFGSNFMH TPMSSRRTKN SKSFLNSMLN
ESRYLNQSNA GSQFIKYGHT PLAIRRIKCA RADIGDVGRE AFMEDVESGR LPHFIDSNLE
QIKELFNQFF DEFNITNYSD VLDFTDEDRS ISEYILLHRD NLKVYLAYYG WKMIKFIETG
RQNECRLNNT NYEDDDENNE NSEGIRNLEH IKSFEIDLTH IFFFNKKLYK LIIEYPSDCI
SEIDKIISTK YNSLLALVLE GDTRSSSSDK YPLSSTKQDY CRVRFFNKKH KDTPRKLGPN
QIETLVCVKG VIIRCSNIIP EMTMAAFKCT SKKRIGVNNY EKCNEEVYEH VIQGEVQEPV
TCSNCNNKNT FELWHNNCCF SSKQLIKLSE VTEHLKQGET PQSISIYAYD DLIDYTKPGD
TVELTGILKA SPVRLNPRSR CYNSVHRTYI NVIHIKKENK QKMKLTEQND TANIILKRNE
DGTVEENFEK LNEQGNLLFT TEVIQKMEQL SKDPNIYQRL VDSIAPSIYG REDIKKGLLC
QLFGGSKITD KYNNKYRSEI HILLCGDPST AKSQLLHYVH KLSPRGIYTS GKGSSSVGLT
AFISKDSETK EYILESGAVV LSDKGICCID EFDKMDDSAR AILHEVMEQQ TVTIAKAGIV
ATLNARTSIL ASANPINSRY DKNKAVVENI NLPPSLFSRF DLIYLVIDQA NEDEDRKLAT
VLCKNFSYNP EEEEDEDQED QEEDEPNYIT QQRARKSKGT SRKNERENYY NDGDNDDDDD
ISNYLNDSND AQNKRGSWAN VNISYDEYNN SSNKKTSKNY LIDSNTLALY IAYCRITCNP
IISLESKKII IEEYIKMRCK EGTKSPTASP RQLEGLVRLS QSLAKMKLKR VVSPEEANEA
VRLMNIATFQ SLIDPLSGRI DFDQVNLGQT SQHKKKSDLI KDIIMNALVL KNMTKDELLT
HCHETIMNDP QHTTSMDRKS FEEAFYDLEK SQEITRLCSG LYKKK
//
