ID A0A0L1KYQ7_9EUGL Unreviewed; 602 AA.
AC A0A0L1KYQ7;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
DE Flags: Fragment;
GN ORFNames=XU18_0719 {ECO:0000313|EMBL:KNH08864.1};
OS Perkinsela sp. CCAP 1560/4.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Prokinetoplastina;
OC Ichthyobodonidae; Perkinsela.
OX NCBI_TaxID=1314962 {ECO:0000313|EMBL:KNH08864.1, ECO:0000313|Proteomes:UP000036983};
RN [1] {ECO:0000313|EMBL:KNH08864.1, ECO:0000313|Proteomes:UP000036983}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCAP 1560/4 {ECO:0000313|EMBL:KNH08864.1};
RA Tanifuji G., David V., Flegontov P., Gerasimov E., Hashimi H.,
RA Logacheva M., Maruyama S., Onodera N., Gray M., Archibald J., Curtis B.,
RA Cenci U., Lukes J.;
RT "Draft genomes of Paramoeba pemaquidensis and its kinetoplastid
RT endosymbiont Perkinsela sp. CCAP 1560/4.";
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|RuleBase:RU367072}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNH08864.1}.
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DR EMBL; LFNC01000041; KNH08864.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L1KYQ7; -.
DR EnsemblProtists; KNH08864; KNH08864; XU18_0719.
DR OrthoDB; 38995at2759; -.
DR Proteomes; UP000036983; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF14500; MMS19_N; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000036983}.
FT DOMAIN 228..371
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT NON_TER 602
FT /evidence="ECO:0000313|EMBL:KNH08864.1"
SQ SEQUENCE 602 AA; 69322 MW; 7D042680A66A1B52 CRC64;
MHEEKGKLEY LSVLIENYCN ANVWSKRTPL YAADIPKMQD KIKSESAEEI PVFFYLDEYL
TPPYGSAADS KSTHTNSKTE NRLLNVVKSL ESSLTNDDED GVRLCAYEVL HRSIDLYFPQ
GYFAQDERSN DIFPSLQGIL KFLIDRLDDI PCMEKIIECL FLLLVSKDSV IQGDVKGWSE
SAQGNTKFHG FSLPLPVRLD IDHPREEPRE THVEALDRRI TSYPHAAIQQ YRWLSVENVA
SILNGICEKT QMEYMRSTHR RQIYDIFLKY LLAHYEYESL RLSSTQTEIY DREMHTYGSQ
VMRCLLPNDF LSNFLECFDN ERDPRNVLSY LEICRRIIHF ASYGEMFSAV GKRVDFFDAF
SCFFPLAYED TGHQTNLTAG SSKSNGQSKG HYEFIPLSPE KKHDANPEAI KKVLHDMLSH
EGFYEFSLPF LLDKMDSPLL DTQMDVLDVF SLVYQREVKI QPYTGNNSTD GTSVLLENAD
LVSDKVIEAI KIVLAKDKTC YQAFYDMLFQ AFLAANHSIR HTERNDSVDR SGPLSAWVEL
TTALNAEEKE ISTNEPTLYA KRAMHFLRMF ASWISTFALD AKEFRPVKSI AERVIHELII
ST
//
