ID A0A0L1LP24_9MICC Unreviewed; 461 AA.
AC A0A0L1LP24;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Cystathionine beta-synthase {ECO:0000256|ARBA:ARBA00026192};
DE EC=4.2.1.22 {ECO:0000256|ARBA:ARBA00012041};
DE AltName: Full=Beta-thionase {ECO:0000256|ARBA:ARBA00030337};
DE AltName: Full=Serine sulfhydrase {ECO:0000256|ARBA:ARBA00031579};
GN ORFNames=ACU18_09765 {ECO:0000313|EMBL:KNH17674.1};
OS Arthrobacter sp. ZBG10.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Arthrobacter.
OX NCBI_TaxID=1676590 {ECO:0000313|EMBL:KNH17674.1, ECO:0000313|Proteomes:UP000036861};
RN [1] {ECO:0000313|EMBL:KNH17674.1, ECO:0000313|Proteomes:UP000036861}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ZBG10 {ECO:0000313|EMBL:KNH17674.1,
RC ECO:0000313|Proteomes:UP000036861};
RA Hoefler B.C., Straight P.D.;
RL Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-homocysteine + L-serine = H2O + L,L-cystathionine;
CC Xref=Rhea:RHEA:10112, ChEBI:CHEBI:15377, ChEBI:CHEBI:33384,
CC ChEBI:CHEBI:58161, ChEBI:CHEBI:58199; EC=4.2.1.22;
CC Evidence={ECO:0000256|ARBA:ARBA00001175};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
CC -!- SIMILARITY: Belongs to the cysteine synthase/cystathionine beta-
CC synthase family. {ECO:0000256|ARBA:ARBA00007103}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KNH17674.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LFQH01000037; KNH17674.1; -; Genomic_DNA.
DR RefSeq; WP_050685352.1; NZ_LFQH01000037.1.
DR AlphaFoldDB; A0A0L1LP24; -.
DR PATRIC; fig|1676590.3.peg.1784; -.
DR UniPathway; UPA00136; UER00201.
DR Proteomes; UP000036861; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0004122; F:cystathionine beta-synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:UniProt.
DR GO; GO:0006535; P:cysteine biosynthetic process from serine; IEA:InterPro.
DR GO; GO:0019343; P:cysteine biosynthetic process via cystathionine; IEA:InterPro.
DR CDD; cd01561; CBS_like; 1.
DR CDD; cd04608; CBS_pair_CBS; 1.
DR Gene3D; 3.40.50.1100; -; 2.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR InterPro; IPR046353; CBS_C.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR005857; Cysta_beta_synth.
DR InterPro; IPR001216; P-phosphate_BS.
DR InterPro; IPR001926; TrpB-like_PALP.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR NCBIfam; TIGR01137; cysta_beta; 1.
DR PANTHER; PTHR10314; CYSTATHIONINE BETA-SYNTHASE; 1.
DR PANTHER; PTHR10314:SF194; CYSTATHIONINE BETA-SYNTHASE; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00291; PALP; 1.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
DR PROSITE; PS51371; CBS; 1.
DR PROSITE; PS00901; CYS_SYNTHASE; 1.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|ARBA:ARBA00023122, ECO:0000256|PROSITE-
KW ProRule:PRU00703}; Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898}.
FT DOMAIN 342..404
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
SQ SEQUENCE 461 AA; 49053 MW; 14FB2843C0F82309 CRC64;
MKYAPSILDL IGNTPLIKLN HVTGDTKATV LVKLEYLNPG GSIKDRIAAQ MIEDAERDGK
LQPGATIVEP TSGNTGVGLA LVAQQKGYKC VFVVPDKVGE DKRAVLRAYG AEVVVTPTAV
PPDSPQSYYG VSDRIVRETP GAYKPDQFSN PAAPESHYRT TGPEIWNDTD GRVTHCVIGA
GTGGTITGTG RYLKEVSADR AAADGGRVRI IGADPEGSVY SGGTGRPYFV EGVGEDMWPG
NYDKSIPDQV IAVSDADSFD MTRRLAREEG LLVGGSSGMA VVAALKAAKN LPESAVVVVI
LPDSGRGYLA KIFNDQWMRS YGFLSGGEET SVGEVIKTKN GELPDLVHIH PNESVRDVIN
IMNEFGVSHI PVLSQEPPVV MGEVLGAVDE RSLTAKLFRG EAKLTDKISQ HMGPKLPVIG
SLETISAARE LLSDVDTVMV TFVGAPVGIL TRHDLLAYLS N
//
