ID   A0A0L6T3M3_9BURK        Unreviewed;        70 AA.
AC   A0A0L6T3M3;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   RecName: Full=GDP-mannose 4,6-dehydratase {ECO:0000256|ARBA:ARBA00011989};
DE            EC=4.2.1.47 {ECO:0000256|ARBA:ARBA00011989};
DE   Flags: Fragment;
GN   ORFNames=AD742_20525 {ECO:0000313|EMBL:KNZ30722.1};
OS   Methylibium sp. NZG.
OC   Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC   Sphaerotilaceae; Methylibium.
OX   NCBI_TaxID=1686064 {ECO:0000313|EMBL:KNZ30722.1, ECO:0000313|Proteomes:UP000053102};
RN   [1] {ECO:0000313|Proteomes:UP000053102}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bi G.;
RT   "Draft Genome Sequences of the MTBE Degrading Bacterium Methylibium sp.
RT   NZG.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=NADP(+); Xref=ChEBI:CHEBI:58349;
CC         Evidence={ECO:0000256|ARBA:ARBA00001937};
CC   -!- SIMILARITY: Belongs to the NAD(P)-dependent epimerase/dehydratase
CC       family. GDP-mannose 4,6-dehydratase subfamily.
CC       {ECO:0000256|ARBA:ARBA00009263}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KNZ30722.1}.
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DR   EMBL; LGRD01000038; KNZ30722.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0L6T3M3; -.
DR   STRING; 1686064.AD742_20525; -.
DR   Proteomes; UP000053102; Unassembled WGS sequence.
DR   GO; GO:0008446; F:GDP-mannose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019673; P:GDP-mannose metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR006368; GDP_Man_deHydtase.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43715:SF1; GDP-MANNOSE 4,6 DEHYDRATASE; 1.
DR   PANTHER; PTHR43715; GDP-MANNOSE 4,6-DEHYDRATASE; 1.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000053102}.
FT   DOMAIN          20..68
FT                   /note="NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF16363"
FT   NON_TER         70
FT                   /evidence="ECO:0000313|EMBL:KNZ30722.1"
SQ   SEQUENCE   70 AA;  7961 MW;  7EA7829E5FC4A926 CRC64;
     MKENHHPEPE RLYGVSKVAL ITGVTGQDGA YLSELLLDKG YTVHGVKRRS SLFNTDRIDH
     LYQDPNVDHQ
//