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Database: UniProt
Entry: A0A0L6T3V5_9BURK
LinkDB: A0A0L6T3V5_9BURK
Original site: A0A0L6T3V5_9BURK 
ID   A0A0L6T3V5_9BURK        Unreviewed;       526 AA.
AC   A0A0L6T3V5;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   23-MAY-2018, entry version 12.
DE   RecName: Full=NAD(P) transhydrogenase subunit alpha {ECO:0000256|PIRNR:PIRNR000203};
DE            EC=1.6.1.2 {ECO:0000256|PIRNR:PIRNR000203};
GN   Name=pntA {ECO:0000313|EMBL:KNZ30826.1};
GN   ORFNames=AD742_20030 {ECO:0000313|EMBL:KNZ30826.1};
OS   Methylibium sp. NZG.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Methylibium.
OX   NCBI_TaxID=1686064 {ECO:0000313|EMBL:KNZ30826.1, ECO:0000313|Proteomes:UP000053102};
RN   [1] {ECO:0000313|Proteomes:UP000053102}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Bi G.;
RT   "Draft Genome Sequences of the MTBE Degrading Bacterium Methylibium
RT   sp. NZG.";
RL   Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The transhydrogenation between NADH and NADP is coupled
CC       to respiration and ATP hydrolysis and functions as a proton pump
CC       across the membrane. {ECO:0000256|PIRNR:PIRNR000203}.
CC   -!- CATALYTIC ACTIVITY: NADPH + NAD(+) = NADP(+) + NADH.
CC       {ECO:0000256|PIRNR:PIRNR000203}.
CC   -!- SIMILARITY: Belongs to the AlaDH/PNT family.
CC       {ECO:0000256|PIRNR:PIRNR000203}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KNZ30826.1}.
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DR   EMBL; LGRD01000037; KNZ30826.1; -; Genomic_DNA.
DR   EnsemblBacteria; KNZ30826; KNZ30826; AD742_20030.
DR   PATRIC; fig|1686064.3.peg.2577; -.
DR   Proteomes; UP000053102; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008750; F:NAD(P)+ transhydrogenase (AB-specific) activity; IEA:UniProtKB-EC.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR   InterPro; IPR007886; AlaDH/PNT_N.
DR   InterPro; IPR007698; AlaDH/PNT_NAD(H)-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR026255; NADP_transhyd_a.
DR   InterPro; IPR024605; NADP_transhyd_a_C.
DR   Pfam; PF01262; AlaDh_PNT_C; 1.
DR   Pfam; PF05222; AlaDh_PNT_N; 1.
DR   Pfam; PF12769; PNTB_4TM; 1.
DR   PIRSF; PIRSF000203; NADP_transhydrogenase_alpha; 1.
DR   SMART; SM01002; AlaDh_PNT_C; 1.
DR   SMART; SM01003; AlaDh_PNT_N; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
DR   TIGRFAMs; TIGR00561; pntA; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000053102};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   NAD {ECO:0000256|PIRNR:PIRNR000203};
KW   NADP {ECO:0000256|PIRNR:PIRNR000203};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR000203};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR000203,
KW   ECO:0000313|EMBL:KNZ30826.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053102};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    409    429       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    435    453       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    460    481       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    493    516       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        4    140       AlaDh_PNT_N. {ECO:0000259|SMART:SM01003}.
FT   DOMAIN      149    313       AlaDh_PNT_C. {ECO:0000259|SMART:SM01002}.
SQ   SEQUENCE   526 AA;  54743 MW;  0AD418131D884907 CRC64;
     MLIGVPLETL PGEKRVATVP EVVEKLIKLG FQVAVQSGAG DAANFADDTY RAAGASVVPT
     AADIWAKSDI VFKARVPTPN EVAMLREGGT LIGFVWPAQN PDLMQQLAAK MATVLAIDCL
     PRQLSRAQKM DALTSMAGIS GYRAVIEAAN AFGRFFNGQI TAAGKIPPAK VFIAGAGVAG
     LAAIGTAANL GAIVRANDTR AEVADQVVSL GGEFVKVDYE EEGSGGGGYA KVMSEGFQAA
     QRAMYAQQAK EVDIIITTAL IPGKPAPKLI TAEMVRSMKP GSVIVDMAAE QGGNCELTEP
     GHAVVKHGVT IVGYTDLVSR LAKQSSTLYS NNLLRLTEEL CKTKDGVINV NMDDDAIRGL
     TVIKEGAVTW PAPPLKLPAP PPQKAATAVA VAPKGHGHGA GEPMSAKSLA TVFGVGAVLF
     LLVGLYAPAS FLSHFTVFVL ACFIGYMVVW NVTPSLHTPL MSVTNAISSI IAIGALVQVA
     PPLTGGIADR PNALILGLAV FALALTAVNM FGGFAVTRRM LAMFRK
//
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