ID   A0A0L6WHN4_9AGAR        Unreviewed;      1119 AA.
AC   A0A0L6WHN4;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   SubName: Full=Rho1 guanine nucleotide exchange factor 1 {ECO:0000313|EMBL:KNZ74609.1};
GN   ORFNames=J132_06563 {ECO:0000313|EMBL:KNZ74609.1};
OS   Termitomyces sp. J132.
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Tricholomatineae; Lyophyllaceae;
OC   Termitomyces.
OX   NCBI_TaxID=1306850 {ECO:0000313|EMBL:KNZ74609.1, ECO:0000313|Proteomes:UP000053712};
RN   [1] {ECO:0000313|Proteomes:UP000053712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J132 {ECO:0000313|Proteomes:UP000053712};
RA   Hu H., Poulsen M.;
RT   "The genome of Termitomyces.";
RL   Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KQ412647; KNZ74609.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0L6WHN4; -.
DR   STRING; 1306850.A0A0L6WHN4; -.
DR   OrthoDB; 5100844at2759; -.
DR   Proteomes; UP000053712; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd04435; DEP_fRom2; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR001180; CNH_dom.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000591; DEP_dom.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR041675; PH_5.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR46572; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR   PANTHER; PTHR46572:SF2; RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED; 1.
DR   Pfam; PF00780; CNH; 1.
DR   Pfam; PF00610; DEP; 1.
DR   Pfam; PF15405; PH_5; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00036; CNH; 1.
DR   SMART; SM00049; DEP; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50219; CNH; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000053712}.
FT   DOMAIN          345..532
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          721..1016
FT                   /note="CNH"
FT                   /evidence="ECO:0000259|PROSITE:PS50219"
FT   REGION          1..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          102..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..26
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        102..135
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1119 AA;  127483 MW;  FEE1A76F6B3A4359 CRC64;
     MDRPLGPRQP PDKRHAAYED IFGRPGASHH RPPPHIPPPY PYRARSVQQY GYHRAPDPPR
     IGLSLDHAGP SSDQGTDEDS ELPWARSDHV VLDSHFVCAP SVPLSSTHTP VPQTPSQRRI
     SRPTLPQQGR SSPASVRPVR KTPIVYPALL SRVAEAFRDR ISLSHRVKDG LTYKAAFDGR
     EAVDKIAYII KTTDRNLALL LGRALDAQKF FHDVTYDHRL RDSASELYHF RTKLPSPFVS
     TLREQEKFDV SRPRKGSVGS DDVPLPSGVF TLLTDCYSPT CSRDQLCYSI ACPRRLEQQS
     RLNMKPQPGL SKQISRESLG DEPGTLWIHS VPQEIVNSVS DAEKKRQEAI NEVIYTERDF
     VRDMEYLRDM WIGRLKDSDV IPVDRRTDFL THVFWNLHDI IAVNTRLRDA LNKRQKSYAV
     VERIGDVLLD VVPHFGPFVQ YGSHQLYGKY EFEKEKNANA AFALFVETTE RLPESRKLEL
     NAYLTKPTTR LARYPLLLEA VLKHTPDDSP DKTALPKVIT IIRDFLRRVN EETGKTENRF
     NLMQLEQQLV FRPGEQVDLL LKEEGRQLIG KDTFNKRDGD IQVYMFDHAI LFTKPMKTKQ
     HEQFKVYRRP IPLELLLIAA PEDAAQTANR RGKHGVVRKQ SLNRVSATGV PPIVVKAEAK
     GQNWINFMHL GRKFYNLVLW APTPVLHKKW LDLIVRQQTL LRDRSMIFDT VVLNEGFFHG
     PNRVNCAAPF NGGRKIVYGT NDGVYITDLR DAGREPTRVL ALLDVSQVDV LEDYQLLIVL
     SERQVITFPL DALDPNDPLA GLKRAKRISS HTSFFKAGFC LGRVLVCIVK SSQLSSTFKT
     LEPIDQNVRG RAKPTFRKLL QGGNDTLKLF REFYIPVEST SIHYLKTKMC VGCSRGFEIV
     DLESLDTQGL LDPNDESLEF VRKRENLRPM AIYRIHNEFL LCYDEFAFYV NKNGRQSRKD
     FMVHWEGNPT GFALHEPYVL AFEPSFVEVR HIETGYLSQV IQGANLRLLF ADTPPSVTNS
     VSPVQIYPPH MGYEYHNHNH NHNPYAAPAH TAYGGYGASP YGQYQHPNSF QQQQQQRNPQ
     GIGRDEILIV SDDRVLALRP TGGSQRLVSD SASMLSVPR
//