ID A0A0L6WXL1_9AGAR Unreviewed; 407 AA.
AC A0A0L6WXL1;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=mRNA m(6)A methyltransferase {ECO:0000256|ARBA:ARBA00012160};
DE EC=2.1.1.348 {ECO:0000256|ARBA:ARBA00012160};
GN ORFNames=J132_07943 {ECO:0000313|EMBL:KNZ80063.1};
OS Termitomyces sp. J132.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Tricholomatineae; Lyophyllaceae;
OC Termitomyces.
OX NCBI_TaxID=1306850 {ECO:0000313|EMBL:KNZ80063.1, ECO:0000313|Proteomes:UP000053712};
RN [1] {ECO:0000313|Proteomes:UP000053712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J132 {ECO:0000313|Proteomes:UP000053712};
RA Hu H., Poulsen M.;
RT "The genome of Termitomyces.";
RL Submitted (JAN-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-
CC methyladenosine in mRNA + H(+) + S-adenosyl-L-homocysteine;
CC Xref=Rhea:RHEA:55584, Rhea:RHEA-COMP:12414, Rhea:RHEA-COMP:12417,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:74411, ChEBI:CHEBI:74449; EC=2.1.1.348;
CC Evidence={ECO:0000256|ARBA:ARBA00036277};
CC -!- SIMILARITY: Belongs to the MT-A70-like family. {ECO:0000256|PROSITE-
CC ProRule:PRU00489}.
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DR EMBL; KQ412260; KNZ80063.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L6WXL1; -.
DR STRING; 1306850.A0A0L6WXL1; -.
DR OrthoDB; 179166at2759; -.
DR Proteomes; UP000053712; Unassembled WGS sequence.
DR GO; GO:0001734; F:mRNA (N6-adenosine)-methyltransferase activity; IEA:UniProt.
DR InterPro; IPR007757; MT-A70-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR12829; N6-ADENOSINE-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR12829:SF2; N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF05063; MT-A70; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51143; MT_A70; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:KNZ80063.1}; Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053712};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:KNZ80063.1}.
SQ SEQUENCE 407 AA; 46151 MW; 96B0D3245F605F1C CRC64;
MREAYAILQR GSARGRLLAE QFHSTEEKFE AICSYITKDD CAKARSLNPG SSSISTICDR
VHFRALIRPH TDITLGHCSY LNTCYSEPTY SQSPSIPPFP GTAHSAGGRG KEKAPCRYLH
YEVDWDEGDG EKSRAMNGKG KEAVKRKKVH KLGIGQGPMG NSMPVLPPQW INCDLRRFDY
SVLGKFHVIM ADPPWDIHMS VRSIVLLLAK FLIMVLQQLP YGTMTDDEMR AMPIPTLQDE
GLLFLWVTGR AMEVGRECMR VWGYTRVDEV IWVKTNQALI RTGRTGHWLN HTKEHMLVGV
KTVTDEFGAL KFPSWVNRGL DTDVIVSEVR ETSRKPDEVY GLIERMCPGG RKIEVFGRKH
NTRPGWLTLG NQLGPDQIYE EDLAARIKAK YPERNMNTMK SSDFEDS
//
