ID A0A0L7K6I7_PLAFX Unreviewed; 1617 AA.
AC A0A0L7K6I7;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=LCCL domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PFHG_00676 {ECO:0000313|EMBL:KOB58927.1};
OS Plasmodium falciparum (isolate HB3).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=137071 {ECO:0000313|EMBL:KOB58927.1, ECO:0000313|Proteomes:UP000054289};
RN [1] {ECO:0000313|EMBL:KOB58927.1, ECO:0000313|Proteomes:UP000054289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HB3 {ECO:0000313|EMBL:KOB58927.1};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum HB3.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Nusbaum C., Devon K., Henn M., Jaffe D.,
RA Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.,
RA Brockman W., MacCallum I.A., Rounsley S., Young S., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Kodira C., Zeng Q., Oleary S., Yandava C., Alvarado L., Wirth D.,
RA Volkman S., Hartl D.;
RT "The genome sequence of the Plasmodium falciparum HB3.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CH671927; KOB58927.1; -; Genomic_DNA.
DR EnsemblProtists; KOB58927; KOB58927; PFHG_00676.
DR VEuPathDB; PlasmoDB:PfHB3_140061500; -.
DR OMA; CQMCCQS; -.
DR Proteomes; UP000054289; Unassembled WGS sequence.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.60.120.1000; -; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.170.130.20; LCCL-like domain; 1.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR036056; Fibrinogen-like_C.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR004043; LCCL.
DR InterPro; IPR036609; LCCL_sf.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR PANTHER; PTHR16146; INTELECTIN; 1.
DR PANTHER; PTHR16146:SF50; LCCL DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF03815; LCCL; 1.
DR SMART; SM00603; LCCL; 1.
DR SUPFAM; SSF56496; Fibrinogen C-terminal domain-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 2.
DR SUPFAM; SSF69848; LCCL domain; 1.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50022; FA58C_3; 1.
DR PROSITE; PS50820; LCCL; 1.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000054289};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1617
FT /note="LCCL domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5005572312"
FT DOMAIN 281..423
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|PROSITE:PS50022"
FT DOMAIN 750..806
FT /note="LCCL"
FT /evidence="ECO:0000259|PROSITE:PS50820"
FT REGION 1442..1470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1617 AA; 184696 MW; 8D17D7FC28C377AF CRC64;
MTKLFFINYA FVIIFSFNLF VKCGDDISNT FFKFEFCEAT STFSSIGENG LPQYAAENAL
TRGSGYWCSE GKHNVNDVVS WIGHLKNVRS LNGIIIHWAY TPGEVSILAS YDGNEPYEEV
VPYQLLESRV GNVVQNIIFN HVIRAKSIKV NMRHAIHDYF GINFTNVLGS RDPTLRIQSG
MSSLTQDLCL QIDEKNEVVL DGCITAISYL DGRDLWKLNS KNQIYNPINN LCITLKDNLI
ANGGRLILED CNASLEHNDG RSSWQLLPNN QLKILRNGNF CLSQDGHKSG SIDVAFHKEC
TSTLSSDNKN HSPDKVVDGL LDTFWVSQEF NLDTAPDSVH FDVNLGSIYK LQKAIIDWKY
PATKYSISLS NDGENYKEVS SNLANFLRST INNLHNTEAQ YIRLTLMAPN PEFSEENKLF
YGIKKFSVYS NRIKSIVDDC DKIKDTDDAR DKYFFEFVSE VNLQEGKELK RLDNELQLYA
EKIQNEALKI QSLNPKLKKC KLEKEKRHKD ISNIKNVILK NIYEVIKQTE NIIKMNPLSS
YYSTSTKELG QTSDNPADNC FHLKNALPSS PSGFYYVLTT CSQNVLRVFC DMKMGATYYI
PSVDNKIINK LKDVENVCAT YGLNPIHLYH ESQIYTLRKV FDTMDINITN PVPLAIRKED
SEFYYSLDFQ TNVHDIIAKF GTPVGNTFGI NNIGITFFDS SSSEMSAFVC SDNINSINLP
EPFVNLDCQS SLKETNEIEK MIGNEYLIKC PHDCLERDIE ESVIGGEGNI YSEDSSICLS
AIHAGIYDKH YLIHLRVINA LNEYGGFFQN GIISESFFNN TQEVGFKLFH VPPKCPKDDI
TSNINNNNNY YYYDNNNSNA MFSFLELDNK MNNVNDKFDN NDYTYVDSST ADAINDLITI
VNKQVGSTDT TFLALINKQS IKIISNARRY LKPTEIFEKN IELLSNETLK DVEKVFNLIK
VLSSKINSEL EKKKYKLEIL VDERLRQKEF ESWKLDNIDN IYDTFEIINS VQLQQIGKWN
ILDNPLYEGI NGITLIQNVR VYNSPENSVI NSFNGSYAFL RYKSFYDFVF STYVNIKGVG
SVGLIFRSYD KYNFYMLELN NDRQKNEFNK RLLKFENNIV TELAIVNGND LQEGDWFVVR
IECIGSKIII TVLKTNKPIY ELPKPDIIIN DDFTSSGTIG FYTYGIDNVQ FTNITVESVE
CSTKEILSYN ISPISCNIYE EYYVGKFNKS YIPFDSENSN SGSSNWKFAK NIGNEKHVIL
QNSNMKQIEN EEQIPSFIIL QNKSCQTGVL NFSVYPECSN GIVGTMFKFL DSKNYTILEI
GSGFTRLRQN VNGKFQLLSK SIISGYKEHI WNRVTVSFSS NNINVNLGTG FMTYPIFSLI
GLHLSDGESV GFTSYNCSNV SFSNIYMHPF DFKPYTPTPT LDTESFLPPI FSKFDQATIK
EEDQSQDMGY KQIGDNKNSD ISKDSPIDKH SFEDSTRQMK KDAYYCATHK NIVDIINYCN
QYDKENDNCT NEFCTICCNN IDTKEEEDIR TCEILCQKLD DKILQTSEVL NYLKKSCIES
PNEELKKSCE DDNDKEECLI EMCEMCCQSV TIPDDLLTSH MDIDSLTNHC ISLCDKP
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