ID   A0A0L7K6J3_PLAFX        Unreviewed;       347 AA.
AC   A0A0L7K6J3;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   03-MAY-2023, entry version 21.
DE   RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
GN   ORFNames=PFHG_00429 {ECO:0000313|EMBL:KOB58681.1};
OS   Plasmodium falciparum (isolate HB3).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=137071 {ECO:0000313|EMBL:KOB58681.1, ECO:0000313|Proteomes:UP000054289};
RN   [1] {ECO:0000313|EMBL:KOB58681.1, ECO:0000313|Proteomes:UP000054289}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HB3 {ECO:0000313|EMBL:KOB58681.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA   Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA   Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA   Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA   Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA   Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT   "Annotation of Plasmodium falciparum HB3.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000054289}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Birren B., Lander E., Galagan J., Nusbaum C., Devon K., Henn M., Jaffe D.,
RA   Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.,
RA   Brockman W., MacCallum I.A., Rounsley S., Young S., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Kodira C., Zeng Q., Oleary S., Yandava C., Alvarado L., Wirth D.,
RA   Volkman S., Hartl D.;
RT   "The genome sequence of the Plasmodium falciparum HB3.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH671923; KOB58681.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0L7K6J3; -.
DR   EnsemblProtists; KOB58681; KOB58681; PFHG_00429.
DR   OMA; DINPAWA; -.
DR   Proteomes; UP000054289; Unassembled WGS sequence.
DR   GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd07302; CHD; 1.
DR   Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR   InterPro; IPR001054; A/G_cyclase.
DR   InterPro; IPR029787; Nucleotide_cyclase.
DR   PANTHER; PTHR43336:SF3; GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR43336; OXYGEN SENSOR HISTIDINE KINASE RESPONSE REGULATOR DEVS/DOSS; 1.
DR   Pfam; PF00211; Guanylate_cyc; 1.
DR   SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR   PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000054289}.
FT   DOMAIN          46..211
FT                   /note="Guanylate cyclase"
FT                   /evidence="ECO:0000259|PROSITE:PS50125"
SQ   SEQUENCE   347 AA;  40921 MW;  EC1F2021853AF638 CRC64;
     MEENLMKLGT LMLLGFGEAG AKIISKNINE QERVNLLING EIVYSVFSFC DIRNFTEITE
     VLKEKIMIFI NLIAEIIHEC CDFYGGTINK NIGDAFLLVW KYQKKEYSNK KMNMFKSPNN
     NYDEYSEKEN INRICDLAFL STVQTLIKLR KSEKIHIFLN NENMDELIKN NILELSFGLH
     FGWAIEGAIG SSYKIDLSYL SENVNIASRL QDISKIYKNN IVISGDFYDN MSEKFKVFDD
     IKKKAERKKR KKEVLNLSYN LYEEYAKNDD IKFIKIHYPK DYLEQFKIAL ESYLIGKWNE
     SKNILEYLKR NNIFEDEILN QLWNFLSMNN FIAPSDWCGY RKFLQKS
//