ID A0A0L7K9Y3_PLAFX Unreviewed; 2862 AA.
AC A0A0L7K9Y3;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Pre-mRNA-splicing helicase BRR2 {ECO:0008006|Google:ProtNLM};
GN ORFNames=PFHG_01860 {ECO:0000313|EMBL:KOB60097.1};
OS Plasmodium falciparum (isolate HB3).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=137071 {ECO:0000313|EMBL:KOB60097.1, ECO:0000313|Proteomes:UP000054289};
RN [1] {ECO:0000313|EMBL:KOB60097.1, ECO:0000313|Proteomes:UP000054289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HB3 {ECO:0000313|EMBL:KOB60097.1};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum HB3.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Nusbaum C., Devon K., Henn M., Jaffe D.,
RA Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.,
RA Brockman W., MacCallum I.A., Rounsley S., Young S., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Kodira C., Zeng Q., Oleary S., Yandava C., Alvarado L., Wirth D.,
RA Volkman S., Hartl D.;
RT "The genome sequence of the Plasmodium falciparum HB3.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CH671953; KOB60097.1; -; Genomic_DNA.
DR EnsemblProtists; KOB60097; KOB60097; PFHG_01860.
DR VEuPathDB; PlasmoDB:PfHB3_040025900; -.
DR OMA; QTEIQYY; -.
DR Proteomes; UP000054289; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProt.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 2.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 6.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041094; Brr2_helicase_PWI.
DR InterPro; IPR048863; BRR2_plug.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR47961; DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED; 1.
DR PANTHER; PTHR47961:SF4; U5 SMALL NUCLEAR RIBONUCLEOPROTEIN HELICASE; 1.
DR Pfam; PF21188; BRR2_plug; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF18149; Helicase_PWI; 1.
DR Pfam; PF02889; Sec63; 2.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00973; Sec63; 2.
DR SUPFAM; SSF81296; E set domains; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054289}.
FT DOMAIN 724..993
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 1004..1241
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 240..322
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 503..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 889..952
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1281..1309
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2131..2152
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2172..2200
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2242..2274
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..297
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 513..546
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 560..578
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 579..606
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 899..936
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1282..1309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2175..2200
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2242..2265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2862 AA; 336645 MW; D9197033DC1760C5 CRC64;
MAEEYEKFKR FEYRMNSNLV LQREGPISNT KEPTGESESL VGRLKYKMGD KVEYSNKNKK
NIMLVQDNKE MAINRNKRKD IFDDDKYNRR SNKKIRHKEK SVLNVNIEDI FLYKPTTKYT
EEIYTKLMSK IRFLLGDNTG DIINSACNEI LYILKNEELN NEEKKKQVES ELEIYINDDI
FIEINNLSKE IYDFNKQEEG EYVENDEGVA VIFEEDDDYF NIGRNITRGY INDHETMELQ
ELSDDNEEED ISEDDDGDDE EEDDEEADAE EADDEDGDDE DGDDEEGDDE YGENEDGDDN
NNNNNNNNSV RRKKKKKGNQ INHLKSYDKK NKKFENYLSL KNTNKNLYYD EENKNVQDND
ELNINVIDSH WLQRELNKIF PDPSLCLDKE KEVLNVLNIY DIQESENKLM HILKYENFHI
ARVLIKNRWK IYYCTLLGQA QTEEEKEEIK KEMKKTEEGQ DILDELCNFK NVRKNKQSEF
SKIIRKEADN LFGKKKINDY NKKGNMSDYT YIHDDDDNDD NNDDNNDDNN DDDDNNDDDE
EKEEGPKYYD EENVSDDDNY YESTKLYNSD SQGEDANKKI NINAKDVKNI KGVKEEDNDG
GSGKEDNEPT QKSFYNNMKY KFIDLEKLET KEKNKDIFFN KEVILPPESK RIERKEYDEI
IISSMKDNKM DGMKRTKNNK MNYYTSPEEI KLIHINELPE WTHEVFSCVN ITKLNPIQSK
VYDVAFNKYE ENMLICAPTG SGKTNIALLC ILNVINSYRL TSGNINRKDF KIVYISPMKA
LVNEQVQSFN LRLKCMNIKV SELTGDVNLS TKELDDSQII VMTPEKFDVI SRKWNEKILL
HKIKLIIFDE IHLLNEMRGN VLESIIARIN RYMDNTMVYD MGDVADGSSG GIRGKNKDAN
RYNNNDDKKN DDNNNDDKKN DDNNNDDKKN DDNNNDDDDN YNGGGVNSVR QNKYGENHIS
IRRKKIRLVG LSATLPNYED VGIFLRAHIE RGIFYFDHSF RPVQIEQHYI GIKEKKGIKK
YALMNELTYE KVLEEAGKNQ ILIFVHSRKE TYRTSKLLID RFMKSDNLSK FLIDKKISSE
ILLSEKEHVI NEELKEILPF GFGIHHAGLK RLDRKLVEDL FSDRHIQVLV CTSTLAWGIN
LPAHTVIIKG TSVYNINIGD FDELSSMDVL QMVGRSGRPQ YDKSGKAIII TDHKNLQLYL
SLNNEQLFIE STLLHNIVNI INAEIVLKNI QNMDDAMNWL EHTYMYIRML KCPSLYGVII
NSNDKIKGIE EFKDIIDMNN KTKKHNNNNN NNINGGNNNN NNNINGGNNN NSNNVMDYMS
ILKTNYKYNK FMEKIKRRMY NILYSCFLIL EKYDLIKYNK KLNTVSSTYI GKISSYYYVD
YKSIDIYNKK LNKYTNEIDL LKIFTMSNEF KNIFIRDEEK TELSIIMEKL PIPVKESINI
PYTKINILLQ LYLSNIILNG YIINADMVYI HQNALRIFRS FFEISLKKNS YNLIKLTLKF
CKMIERRMWS TMTPLRQFGL LSTELIRIIE KKNITFKNYL TMNLNEYITI FKNKKIAKNI
YKLVHHFPKL ELNAYIQPIN HKILKVDLNI APDFIYNPKY HGYFMLFWVF VFDISNESIL
HYDLFTLKKN YKNDILNQTQ RYNNNGNNSN MYNPSDVLDD HVLTFFLPIN DNPFYIVKVI
SDKWLECEAT INLYLKDLIL PSQNFYSTQL LDLQPLPIHS IKYDKAHTFF NNIRNLHYFN
SIHTQIFSSI FENNGNVLIA SSNSKHYLIP AELGMIKILK FLHCFYNFIN TYIKKEKDVY
KIINDKKLAD LLYNNNLIDL IKIVYIAPLD DVIIKTFKNW QAMKKTFDLK MCILTGDIQI
DMKLLQTHHI ILSNPSNYDN ISKKWRRKKI LQTVSFYIFD HMELLDTVQG GIMEILISRI
RYISTQLNIN KSEKKNQHNN DNNNNDNLIM SILNIDMIKM DNVEDDNNKK NIIQNNNNNN
SNSKKDDFVQ TINALQNFTI DNIYDYIGLN RILCLSSCSL YNSKDFAEWI GCKKNDYYNF
LSTVRDIPIE IYLHAVNIMN KQNRYISMQR QVYQNIRKLK NIPKKKKMQN VIIFVTDQKL
CKTLALDLIL SAYNDNFKYF SLFENYEDDK YDTSKSSTNP YDPKNEEKEK KKGGGWISNL
FTYNKDDKIG RHNESNDLIN NNSHDDTTSN NLQKSGTFRS NDLYNNGTNV EELAKSIHNM
INLNISNMDI IKNKEVAENN MNVASSNNNN NNNSNSNNIY KNGRKRSNNR NNKNEEHVFD
YINDKMLRQF MKKGICYLHN NMTEIEKKIV EILFDKKTIQ ILIVSYDYIY SLNVYANNVI
ILDTIITHFH NNKEEDYSIQ NILEMISYAG RQNEDTKAFV YIYTYITKKE YYKNFIYEPL
TVESNIEDNL PNFLNNEIVM STIENYQDAI DWLTWSFFYR RIKKNPNYYG LKGISNEHIS
DYLSELIENN MEILSFANCI NIEEQTMDIK PCNLGIISSF YNLDYHIIHF FNQYVLSLKT
LKKSRIFEII CLSNIFNDIL KIHNYDIFLC LKIAQACNNV QVTYEFLKLS INNENTLKNA
NIEDNLNKDT KSEDYKKDQY INLLQFMSVP MYFTSHLKAF ILLQAHIHRY SLPLNYIQET
KTVLLKAYKL INSLIDVISS NNILNFCLFV MEVSQMLTQS MKSTDQSNLY QLPHFDEHLI
KKANDLEILD VYDLINAEDE PRDILLKHLN EKQRSEIANV CNIFPIIEVQ YEIDLDKSYK
VNEIAQLNLT IERDLTDDAV IFAHSLYLPF EKEEMWWIVI GIKKMNLLLS IKKLSLLKSV
NNIKINFELP DKPNTYDVVI YVINDCYVGC DQEYEFKINV EE
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