ID A0A0L7KAY0_PLAFX Unreviewed; 1397 AA.
AC A0A0L7KAY0;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Glutamate/phenylalanine/leucine/valine/L-tryptophan dehydrogenase C-terminal domain-containing protein {ECO:0000259|SMART:SM00839};
GN ORFNames=PFHG_02330 {ECO:0000313|EMBL:KOB60543.1};
OS Plasmodium falciparum (isolate HB3).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=137071 {ECO:0000313|EMBL:KOB60543.1, ECO:0000313|Proteomes:UP000054289};
RN [1] {ECO:0000313|EMBL:KOB60543.1, ECO:0000313|Proteomes:UP000054289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HB3 {ECO:0000313|EMBL:KOB60543.1};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum HB3.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Nusbaum C., Devon K., Henn M., Jaffe D.,
RA Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.,
RA Brockman W., MacCallum I.A., Rounsley S., Young S., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Kodira C., Zeng Q., Oleary S., Yandava C., Alvarado L., Wirth D.,
RA Volkman S., Hartl D.;
RT "The genome sequence of the Plasmodium falciparum HB3.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
CC {ECO:0000256|ARBA:ARBA00006382}.
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DR EMBL; CH671966; KOB60543.1; -; Genomic_DNA.
DR SMR; A0A0L7KAY0; -.
DR EnsemblProtists; KOB60543; KOB60543; PFHG_02330.
DR VEuPathDB; PlasmoDB:PfHB3_080007100; -.
DR OMA; LYCLPQN; -.
DR Proteomes; UP000054289; Unassembled WGS sequence.
DR GO; GO:0004352; F:glutamate dehydrogenase (NAD+) activity; IEA:InterPro.
DR GO; GO:0019551; P:glutamate catabolic process to 2-oxoglutarate; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR InterPro; IPR006096; Glu/Leu/Phe/Val/Trp_DH_C.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR028971; NAD-GDH_cat.
DR PANTHER; PTHR11606; GLUTAMATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11606:SF42; NAD-SPECIFIC GLUTAMATE DEHYDROGENASE; 1.
DR Pfam; PF05088; Bac_GDH_CD; 1.
DR Pfam; PF00208; ELFV_dehydrog; 1.
DR SMART; SM00839; ELFV_dehydrog; 1.
DR SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000054289}.
FT DOMAIN 946..1294
FT /note="Glutamate/phenylalanine/leucine/valine/L-tryptophan
FT dehydrogenase C-terminal"
FT /evidence="ECO:0000259|SMART:SM00839"
FT REGION 768..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..865
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1236..1256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 768..782
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 783..811
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1239..1256
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1397 AA; 160425 MW; C86D83AEE872965A CRC64;
MDIDRRSALS CSPNNMECGF GSGHFSNNSI TWKEKYEQTK ELLKSYNLFS DHLINYSIDF
YFNKLGFNKF HFEETSPELI SKVVVCIITA KINEQYSSDK YFPTFEETHD NVIFIITRVF
ADDNKTRLNY KMEKKIEEKY FNFSDMSKDC YRLKSFRSVH SVFDKEHTYQ EPLRTYILEL
PTYNDDIIKE NETDLKKLMD VNFYNYIKGT RSEQIYYELN KAVLYDLTGQ FLQTHYYETS
SSTFTLTIAV KRSNVISSIF SLIGDCLNMH RCFSYSKYVE PLKNGVLLII LNVKVIVNNE
MEREKQKLDL KDKIYKVVKS LKTLCLFNDS KFIQLSVKRT FTAQESAYLF MIIKFITFFS
TNTLSSYKNV EHALNLRNYN NNIMDTTTNS SSSPSSVLND VYIIKEKLKS SKYTKEEILR
CAQSNVRTIK MLFANFEKKL NHQRNKCNQM KYGENNMKNS GDLLKEYSTN NRNVDHPTLS
SLASSSSSCS SSFSLHSYLS GSYESPYYHH NKDSKDIIDE IEDNHDKKIL QYFYMFEKYA
LKTNFFLTHK ISLAVAFDGA LLKDSIYEAQ PYSIIMILGL HFVGFHIRFS KISRGGVRIV
ISNNVNSYMH NSDNLFDEAY NLAYTQNFKN KDIPEGGSKG IILLDADVCN VANTKYIKNL
SFYSYVNSIL DLLINEDLNE ESASSISVHS TKGANNTTIT FDNVMSSVEN MVDRGGVEGE
HLNITLPYDA NMACNNNTTN DNLSNMHDTY NLNNSGEATL DHHSVDNRIV SNSSGTNNMN
AQKGEGEDEK AKDKEMSNNR KNEENERKRC DNVSNSNYNY VNGTTEDAVQ KIMGSKCKGG
RNNNGEEKDG DMNGHNNNNN DNNNIDDDEH IEECYKGAGC VINGENKTRK MILQEKMNEE
EDLIFLGPDE NTGSDQLMDW ACIIAKKRKY PYWKTFSTGK LRKNGGVPHD MYGMTTLGIE
TYISKLCEKL NIKEESISRS LVGGPDGDLG SNAILQSKTK IISIIDGSGI LYDKQGLNKE
ELIRLAKRRN NKDKSKAITC CTLYDEKYFS KDGFKISIED HNVDIFGNKI RNGLDFRNTF
FLNPLNKCEL FNPCGGRPHS INIFNVNNII KNGECIYKYI VEGANVFISD DARNILESKN
VILFKDAATN KGGVISSSLE VLAGLVLDDK QYIDYMCSPD SDILQVDENE INFVHQNQKM
NHSLSFKRGS INNLEEDEKK DTSNNEKNKN IIKTVNKNDT QDNSHHHNNS NKCNEDQQDV
SDFYKAYVKE IQKKITHYCE LEFESLWKET RRTKTPISKA INILSNKISE LKKDILSSDT
LCRDYKLLKK VLERVIPPTL LKIVTFEQIL ERVPYVYIKS LFASSLASNY YYSQQFLNDL
SAFNFFEYIT KLQSESA
//
