ID   A0A0L7KEX1_PLAFX        Unreviewed;       679 AA.
AC   A0A0L7KEX1;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   27-MAR-2024, entry version 26.
DE   RecName: Full=Translation initiation factor eIF2B subunit beta {ECO:0000256|ARBA:ARBA00044122};
DE   AltName: Full=eIF2B GDP-GTP exchange factor subunit beta {ECO:0000256|ARBA:ARBA00044228};
GN   ORFNames=PFHG_03643 {ECO:0000313|EMBL:KOB61873.1};
OS   Plasmodium falciparum (isolate HB3).
OC   Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC   Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX   NCBI_TaxID=137071 {ECO:0000313|EMBL:KOB61873.1, ECO:0000313|Proteomes:UP000054289};
RN   [1] {ECO:0000313|EMBL:KOB61873.1, ECO:0000313|Proteomes:UP000054289}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HB3 {ECO:0000313|EMBL:KOB61873.1};
RG   The Broad Institute Genome Sequencing Platform;
RA   Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA   Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA   Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA   Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA   Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA   Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT   "Annotation of Plasmodium falciparum HB3.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000054289}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Sequencing Platform;
RA   Birren B., Lander E., Galagan J., Nusbaum C., Devon K., Henn M., Jaffe D.,
RA   Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.,
RA   Brockman W., MacCallum I.A., Rounsley S., Young S., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Kodira C., Zeng Q., Oleary S., Yandava C., Alvarado L., Wirth D.,
RA   Volkman S., Hartl D.;
RT   "The genome sequence of the Plasmodium falciparum HB3.";
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC       {ECO:0000256|ARBA:ARBA00004514}.
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits family.
CC       {ECO:0000256|ARBA:ARBA00007251, ECO:0000256|RuleBase:RU003814}.
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DR   EMBL; CH672027; KOB61873.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0L7KEX1; -.
DR   SMR; A0A0L7KEX1; -.
DR   EnsemblProtists; KOB61873; KOB61873; PFHG_03643.
DR   VEuPathDB; PlasmoDB:PfHB3_120055400; -.
DR   OMA; NEMMIAY; -.
DR   Proteomes; UP000054289; Unassembled WGS sequence.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR042529; IF_2B-like_C.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   PANTHER; PTHR45859; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA; 1.
DR   PANTHER; PTHR45859:SF1; TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA; 1.
DR   Pfam; PF01008; IF-2B; 1.
DR   SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000054289}.
SQ   SEQUENCE   679 AA;  78752 MW;  10D3FCA9A1BAFD3A CRC64;
     MDLHVKKNNY DQVLNINKNQ GNSNYDLIEI KNNTNNNNNS NNNNNNNKLI EHNHFNNIDE
     QTKEKQNVFY DNDVREVNTN VTSNVKENKP SKNNTDTNVY LSINRCVNNE CSKKEDYYKD
     VYNNISHILD HGLANKSCVP KGCLELDNKK DVFNKMININ SNICNTNNKD IYNKITNEHN
     YKDLNSLNHI NDEEKKSNIP NENILREKSA HCEDEKKSEA WNYKESINYN KNQFEKKKKK
     SFEEKKERQK ELFVAYWLNG IVDLLKRGFK NGNICGSNSV GKKIAEVLKK IVEIYQWKNV
     FDLIEIIKYL GKQIIKNNKM FFVIPNIIRR VLTIIRVEHF KQLYLYNNNY MDNINMFDDK
     VCEENRGTQS PNNYCHNNNK NNCIDNNIFY DKNKVKKKNT MPIPKEGSKN IAKFDINSNT
     LYQREIKNFQ KSFSFYFEKP CNENTYKIPA TNTLKHSIIE GIEELIAEID TSWEEAEQRT
     SYDLFTENDV ILTLGYSAGV EKFLKTINKK KDGISVIVVG GDINRNGFRM SQLLSDDGVD
     TTYISDAAVF AVIPKVTKVV LGSVAVSSSG GTITKMGGYN IACSAHLYSK PVIIVLPLFK
     LIYVPLYDPL KQNELQPGPS LIYNDEDVEN LHVRIPKYDY IPEHLITLYI TEMGPVDSFQ
     LYNITKKRYH PDDMDLSFD
//