ID A0A0L7KIH7_PLAFX Unreviewed; 897 AA.
AC A0A0L7KIH7;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=choline-phosphate cytidylyltransferase {ECO:0000256|ARBA:ARBA00026101};
DE EC=2.7.7.15 {ECO:0000256|ARBA:ARBA00026101};
GN ORFNames=PFHG_04662 {ECO:0000313|EMBL:KOB62885.1};
OS Plasmodium falciparum (isolate HB3).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=137071 {ECO:0000313|EMBL:KOB62885.1, ECO:0000313|Proteomes:UP000054289};
RN [1] {ECO:0000313|EMBL:KOB62885.1, ECO:0000313|Proteomes:UP000054289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HB3 {ECO:0000313|EMBL:KOB62885.1};
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum HB3.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054289}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Nusbaum C., Devon K., Henn M., Jaffe D.,
RA Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.,
RA Brockman W., MacCallum I.A., Rounsley S., Young S., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Kodira C., Zeng Q., Oleary S., Yandava C., Alvarado L., Wirth D.,
RA Volkman S., Hartl D.;
RT "The genome sequence of the Plasmodium falciparum HB3.";
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the cytidylyltransferase family.
CC {ECO:0000256|ARBA:ARBA00010101}.
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DR EMBL; CH672109; KOB62885.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0L7KIH7; -.
DR EnsemblProtists; KOB62885; KOB62885; PFHG_04662.
DR VEuPathDB; PlasmoDB:PfHB3_130023000; -.
DR OMA; IRWGEKV; -.
DR Proteomes; UP000054289; Unassembled WGS sequence.
DR GO; GO:0004105; F:choline-phosphate cytidylyltransferase activity; IEA:InterPro.
DR CDD; cd02174; CCT; 2.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR InterPro; IPR041723; CCT.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR045049; Pcy1-like.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR NCBIfam; TIGR00125; cyt_tran_rel; 2.
DR PANTHER; PTHR10739:SF13; CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE; 1.
DR PANTHER; PTHR10739; CYTIDYLYLTRANSFERASE; 1.
DR Pfam; PF01467; CTP_transf_like; 2.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 2.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW Reference proteome {ECO:0000313|Proteomes:UP000054289}.
FT DOMAIN 36..180
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
FT DOMAIN 622..766
FT /note="Cytidyltransferase-like"
FT /evidence="ECO:0000259|Pfam:PF01467"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 565..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..518
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 578..600
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 897 AA; 104897 MW; 55937B742125A9D3 CRC64;
MIIKVNSVQT QKSQDGNKVH NSQDDMDNEE KSIRIYADGV YDLLHLGHMK QLEQAKHVDK
NVTLIVGVTG DNETRKFKGQ IVQTLEERTE TLKHIRWVDE IISPCPWVIT PEFMEEHKID
YVAHDDIPYA NNQKKKKKKK SKGKSFSFDE ENEDIYAWLK RAGKFKATQR TEGVSTTDLI
VRILKNYEDY IERSLQRGIH PNELNIGVTK AQSIKMKKNL IRWGEKVTDE LTKVTLTDKP
LGTDFDQGID IIRDKVHDLF KLWRYHSKKL LKDFAKSFDP MFIIIRKRYR KDNLSAMYLS
DSNYFSSSMK DELKKKKSLS STFNNIDEYY YSADEEDTRD NSFYRVINKI ANHTYYSEKE
NYETCFELEH SLRDKKKSLI FKDKNMKLSP DDLLHFTNPM NSKYDHNYYY YNNTYDKLSN
VTFNLNGIKK KSYDNESSYI KTAYHDIIDE DKNLLNKEKS FNKDEKKKKK SILETDQYKN
CEDQQFDNKY NHIIIGKKKS DSTYDNSLDK ESSNEKKLSI DKGQYSNMDS SNYFHDCKTM
LSEHNESIES SNNDINGKQK EHIKKGNSEN QDVDPDTNPD AVPDDDDDDD DNSNDESEYE
SSQMDSEKNK GSIKNSKNVV IYADGVYDML HLGHMKQLEQ AKKLFENTTL IVGVTSDNET
KLFKGQVVQT LEERTETLKH IRWVDEIISP CPWVVTPEFL EKYKIDYVAH DDIPYANNQK
KKKKKKSKGK SFSFDEENED IYAWLKRAGK FKATQRTEGV STTDLIVRIL KNYEDYIERS
LQRGIHPNEL NIGVTKAQSI KMKKNLIRWG EKVTDELTKV TLTDKPLGTD FDQGVENLQV
KFKELFKIWK NASNKLITDF TRKLEATSYL TSIQNIIDYE IENDDYASSN FDDETSS
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