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Database: UniProt
Entry: A0A0L7KYY4_9NEOP
LinkDB: A0A0L7KYY4_9NEOP
Original site: A0A0L7KYY4_9NEOP 
ID   A0A0L7KYY4_9NEOP        Unreviewed;       962 AA.
AC   A0A0L7KYY4;
DT   11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT   11-NOV-2015, sequence version 1.
DT   05-JUN-2019, entry version 18.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
GN   ORFNames=OBRU01_18562 {ECO:0000313|EMBL:KOB68271.1};
OS   Operophtera brumata (winter moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Lepidoptera; Glossata; Ditrysia;
OC   Geometroidea; Geometridae; Larentiinae; Operophtera.
OX   NCBI_TaxID=104452 {ECO:0000313|EMBL:KOB68271.1, ECO:0000313|Proteomes:UP000037510};
RN   [1] {ECO:0000313|EMBL:KOB68271.1, ECO:0000313|Proteomes:UP000037510}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WM2013NL {ECO:0000313|EMBL:KOB68271.1};
RC   TISSUE=Head and thorax {ECO:0000313|EMBL:KOB68271.1};
RX   PubMed=26227816; DOI=10.1093/gbe/evv145;
RA   Derks M.F., Smit S., Salis L., Schijlen E., Bossers A., Mateman C.,
RA   Pijl A.S., de Ridder D., Groenen M.A., Visser M.E., Megens H.J.;
RT   "The Genome of Winter Moth (Operophtera brumata) Provides a Genomic
RT   Perspective on Sexual Dimorphism and Phenology.";
RL   Genome Biol. Evol. 7:2321-2332(2015).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-
CC         COMP:11130, Rhea:RHEA-COMP:11131, ChEBI:CHEBI:33019,
CC         ChEBI:CHEBI:61560, ChEBI:CHEBI:83828; EC=2.7.7.7;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|RuleBase:RU000442}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KOB68271.1}.
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DR   EMBL; JTDY01004344; KOB68271.1; -; Genomic_DNA.
DR   OrthoDB; 20210at2759; -.
DR   Proteomes; UP000037510; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.132.60; -; 1.
DR   Gene3D; 3.30.420.10; -; 1.
DR   Gene3D; 3.90.1600.10; -; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR042087; DNA_pol_B_C.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|RuleBase:RU000442};
KW   Complete proteome {ECO:0000313|Proteomes:UP000037510};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|RuleBase:RU000442};
KW   Iron {ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|RuleBase:RU000442};
KW   Nucleotidyltransferase {ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000037510};
KW   Transferase {ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN      111    367       DNA_pol_B_exo1. {ECO:0000259|Pfam:
FT                                PF03104}.
FT   DOMAIN      401    830       DNA_pol_B. {ECO:0000259|Pfam:PF00136}.
FT   DOMAIN      868    940       zf-C4pol. {ECO:0000259|Pfam:PF14260}.
FT   REGION        1     73       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A0L7KYY4}.
FT   COMPBIAS      1     21       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A0L7KYY4}.
SQ   SEQUENCE   962 AA;  108656 MW;  3CD245CDE9C7378F CRC64;
     MDKRKQTKGP PPKRFKSQDD DDDNDNEVPS SFEEQLAGMD TAEDTQVFGE GPENQASNMK
     WSRPPPPALN PKKDSLVFQQ LDIDHYNGQP VQGMPGSQLA PVPIMRMYGV TMDGNSVCCH
     VHGFTPYFYV TVPVNFTEST CNEMKTSLNR AVLEDMRSNK DSIKEAVLEV RLVKAKSLMY
     YKGDDDITLA RVSVALPKII AAGKRLIERQ PPSFSLMDPS FFESNIDFDI RFMVDTSVVG
     CSWIELPQGR WSVRSNTSHI RCESRCQIEV DVAWNAFIAH QPEGEWSKVA PFRILSFDIE
     CAGRKGVFPE PNHDPVIQIA SMVIRQGETE PYLRNVFTLN TCAPIVGSQV LSFQSESEML
     AKWSDFFPMY CLKDAYLPLK LLNKLMCIIN YMEMARVTGV PLLCLLTRGQ QIKVVSQLLR
     KAKEAGYLMP AYHGTGSDDQ FEGATVIEPK KGYYADPIST LDFASLYPSI MMAHNLCYTT
     LVPPNMQSKL QITNDDLTTT PTKNMFVKAT VRKGLLPEIL ESLLAARKKA KADLKDEKDP
     FKRSVLDGRQ LALKISANSV YGFTGAQVGK LPCLEISGSV TAYGRTMIEF TKTEVEKKFT
     KANGYKEDAV VIYGDTDSVM VKFGVKTLEE SMELGREAAV FVTDKFVKPI KLEFEKVYYP
     YLLINKKRYA GLYFTRPDKY DKMDCKGIET VRRDNCQLVS NMMSTCLQKL LIDRDPDGAV
     NYAKQIISDL LCNRIDISQL VITKELTKNE YAAKQAHVEL ANKMRKRDAG TAPKLGDRVP
     YVICCAAKNT PAYMKAEDPI YVLENSIPID FNYYLENQLS KPLLRIFEPI LGEKAESLLL
     KGEHTRTKAM VTSKVGALAA FTKKTEKCIG CKVVMPKDTK KALCNHCMDK EGQLYITEVF
     KLRQLQAKFA RLWTECQRCQ GSLHEEVLCT NRDCTIFYMR KKMGIELDAQ EKSISRFGES
     IW
//
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