ID A0A0L7LXC5_PLAF4 Unreviewed; 1998 AA.
AC A0A0L7LXC5;
DT 11-NOV-2015, integrated into UniProtKB/TrEMBL.
DT 11-NOV-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Clathrin heavy chain {ECO:0000256|PIRNR:PIRNR002290};
GN ORFNames=PFDG_00199 {ECO:0000313|EMBL:KOB84890.1};
OS Plasmodium falciparum (isolate Dd2).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=57267 {ECO:0000313|EMBL:KOB84890.1, ECO:0000313|Proteomes:UP000054282};
RN [1] {ECO:0000313|Proteomes:UP000054282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Volkman S.K., Neafsey D.E., Dash A.P., Chitnis C.E., Hartl D.L.,
RA Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A., Borenstein D.,
RA Chapman S.B., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA Griggs A., Gujja S., Heilman E.R., Heiman D.I., Howarth C., Jen D.,
RA Larson L., Mehta T., Neiman D., Park D., Pearson M., Roberts A., Saif S.,
RA Shea T., Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J.,
RA Yandava C., Haas B., Henn M.R., Nusbaum C., Birren B.;
RT "Annotation of Plasmodium falciparum Dd2.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000054282}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Sequencing Platform;
RA Birren B., Lander E., Galagan J., Nusbaum C., Devon K., Henn M., Jaffe D.,
RA Butler J., Alvarez P., Gnerre S., Grabherr M., Kleber M., Mauceli E.,
RA Brockman W., MacCallum I.A., Rounsley S., Young S., LaButti K.,
RA Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA Kodira C., Zeng Q., O'Leary S., Yandava C., Alvarado L., Wirth D.,
RA Volkman S., Hartl D.;
RT "The genome sequence of Plasmodium falciparum Dd2.";
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Clathrin is the major protein of the polyhedral coat of
CC coated pits and vesicles. {ECO:0000256|PIRNR:PIRNR002290}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane, coated pit
CC {ECO:0000256|PIRNR:PIRNR002290}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR002290}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR002290}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the clathrin heavy chain family.
CC {ECO:0000256|PIRNR:PIRNR002290}.
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DR EMBL; DS016072; KOB84890.1; -; Genomic_DNA.
DR EnsemblProtists; KOB84890; KOB84890; PFDG_00199.
DR VEuPathDB; PlasmoDB:PfDd2_120023800; -.
DR OMA; HCYDLLH; -.
DR Proteomes; UP000054282; Unassembled WGS sequence.
DR GO; GO:0030132; C:clathrin coat of coated pit; IEA:InterPro.
DR GO; GO:0030130; C:clathrin coat of trans-Golgi network vesicle; IEA:InterPro.
DR GO; GO:0071439; C:clathrin complex; IEA:InterPro.
DR GO; GO:0032051; F:clathrin light chain binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.25.40.30; -; 1.
DR Gene3D; 1.25.40.730; -; 1.
DR Gene3D; 2.130.10.110; Clathrin heavy-chain terminal domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR012331; Clathrin_H-chain_linker.
DR InterPro; IPR016025; Clathrin_H-chain_N.
DR InterPro; IPR022365; Clathrin_H-chain_propeller_rpt.
DR InterPro; IPR016341; Clathrin_heavy_chain.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR10292:SF1; CLATHRIN HEAVY CHAIN; 1.
DR PANTHER; PTHR10292; CLATHRIN HEAVY CHAIN RELATED; 1.
DR Pfam; PF00637; Clathrin; 7.
DR Pfam; PF01394; Clathrin_propel; 1.
DR PIRSF; PIRSF002290; Clathrin_H_chain; 1.
DR SMART; SM00299; CLH; 7.
DR SUPFAM; SSF48371; ARM repeat; 7.
DR SUPFAM; SSF50989; Clathrin heavy-chain terminal domain; 1.
DR PROSITE; PS50236; CHCR; 6.
PE 3: Inferred from homology;
KW Coated pit {ECO:0000256|PIRNR:PIRNR002290};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR002290}; Membrane {ECO:0000256|PIRNR:PIRNR002290};
KW Reference proteome {ECO:0000313|Proteomes:UP000054282}.
FT REGION 143..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1925..1952
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 148..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1998 AA; 233051 MW; 0387CCD84449F80F CRC64;
MSQNNPLSVC VADNLINYDI QNESFRLGNV SVEGDKYICV KENVNENTQV VVINLHNKNS
TRKHMKAESV IIHPNDPILA LKGTIKNMNT IFLQVFNIET KEKICSLNLN EYMNYWKWIN
NDTIAIVCEK NVYHWNIDIH NTKKNKDNND NNNNNNNNNN NNNNNNYFNT LTKVFEKAQI
FIDNNSQILY YSTDKDMKWC ILCGISTQDQ GKSIDGYMQL YSCEKKLHQT IEGFIGCFGS
FVFDNLDMKP LFCFVEKKKN STISRLHLMD IYTNKTETTI PYKIVKEINL INENLNDFPI
YISLNTLQGV IYIVTKCSYV YVFDEGTLSL IVKEKISEDN IFICCDSKNG EGIYAVNKKG
IIFYITINYF HLINHLKLSN LEFKDKIIKN LCVKYGYPGC DYISAYKKCI NDMDFKKASK
IICLMKNTKI FEEHSNNIAE SILIMNRKNI DIRIIPPLRT QQVLNSFKSF KNTSGQLSPL
LLYFSVLLEY DKLNTYESIE LVKPVVLQKK KEYLEKWIKD DKLTCSEELG DLVKVLDLRL
ALNIYLRCSS HNKILSTYCL LNMFNNVLSY INNFKQINFD YVGIFITIVN YEFPQGNADN
KDSAFVGDFN SGSKNETMDF FNDGAASISN DQNNSINKLN KGHINEVAIQ YIKFLCENNI
SFDINKIIDY LLSKKKLQEA TSILLDYLKE NKAEHKNLQT KLFEFNLYNN VQVAETLFQM
DIFTYYDKNK IAYLCEEKGL YQRALENYTN INDIKRVITK STCFQKGGNN NNTTTTTTTT
TSNMGDGHFD MNNVSKGKIS IEWIKNYFST LSDSVCEELL FDFMKGSKIN MEVVISICVQ
YYDKIGIKKI INKFEENKNY EGIFYFVSNI LNDLPNLIVK GNNNDNLSNN SLSTYNNMND
EDASILLTSD ICSTPQYSYE TANLKLEDVH YIMFKYIEAC VKINNIQELD RICKDKNAKY
NPEQIKNFLK DCKLSDPRPL IYVCDIHNYI EELAEYLYKN SLLKYIEVYV IKVNPNNAHK
VIGVLLDLDA SEDFLLNLLN NIKNISNIGN LIEIAEKRNR LKLLLPWLES RANEGYENIE
LHNALAKIYI DLNKDPENFL KNNNFYDKKM IGKYCEDLDP HLAYTAYERS NGECDEELIY
ITSKNGLFKL QARYLISRQS IELWKVVLDE TNKYRKNVID QVIGSTLIES NNADEITVTV
KAFIEKKLSS ELIELLEKIV LHNSEFSDNK NLQNLLILTA IKSDSKKVME YINRLDNFSG
PQIAAVAYEY KLREEAFVIY KKFNCYTSAI SVLLDKILYN KNQKNKNFHE FSSHDSTVPY
YSNNNNKDNI FGNKSDNEND EYLKQFTQNN SYREKYGSYY NNNDISNSNN NNIHLHPEFN
NEDKFSSDTL HNYEDIDSTE STCDLSNYED DLNRAIEFAQ KCNNNDVWFI LGKAQLKLNK
IIDSIDSFVK SNNPEAYKEV IEKCKENNFY EHLITYLNTL REQNSLKDVL VDSELLYAYA
KLKKTNEMNK FINTTNSANL QLIGDRLYKE EEYEVAKILY SNIPNNQKLT ACYLKLKEYA
LAIEAAKKAK SLKTWKEVNF ICVKYKQLKY AHTAGLQLIM HADHLDEIIK IYEKKKYINE
LMNLLENGLN NERAHVGIYT ELGILYAKYK PEKLMEFIRN YTNKMNTRKL IDVCENEYLL
KEAVYLYISY DEYNLAVDTI IKHSPTAYTA DTFMQVIHKV TNSDIIHKVI DFYIEEHPLN
LYNLLKILEN KIDNNRLVQT LKKSNNLPLI QKYLEDIQAQ NITAVNETLN EIYLQNDDYI
SLRNSIDEYD NFNQTNLLNK LENHKLPEMR RIAALLYKKN KKYKEAINLS KKEKQYKDAI
EIARVSKNNV YIEDLINYFI ESKNKEAFCA CLIVCYDLLK PDYILEIVWT SGFKDQAMLY
FIQIISDYTN QIEHMKKQIE DMEKEKKMNK SAPNDYSAMN NQFNYSLNNN LSIMPPQNNF
MSSNSFDKYD MFNNNTHF
//
